DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tm1 and tpma

DIOPT Version :9

Sequence 1:	NP_732006.2	Gene:	Tm1 / 41852	FlyBaseID:	FBgn0003721	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_571180.1	Gene:	tpma / 30324	ZFINID:	ZDB-GENE-990415-269	Length:	284	Species:	Danio rerio

Alignment Length:	336	Identity:	144/336 - (42%)
Similarity:	205/336 - (61%)	Gaps:	60/336 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 KKKKREKGERSEKSDKSEKSDRKKKSSGKKERSKRSNPMEQSSDSLATDLSAGAIDEGIALADDD 436
            ||.:..|.::....|::|:::..||::  :||||      |..|.|.      |:.:.:...:|:
Zfish     6 KKMQMLKLDKENALDRAEQAETDKKAA--EERSK------QLEDDLV------ALQKKLKATEDE 56

  Fly   437 DNQAAEWSKLRCTSEAAEIVAEREARRNKGRCADYPGLAFGRSIFSSDTMMKFNIIRNELHNIMN 501
            .::.:|  .|:...|..|: ||::|                     :|
Zfish    57 LDKYSE--ALKDAQEKLEL-AEKKA---------------------TD----------------- 80

  Fly   502 TQLKRAESEVAALNRRIQLLEEDLERSEERLGSATAKLSEASQAADESERARKILENRALADEER 566
                 ||.:||:|||||||:||:|:|::|||.:|..||.||.:|||||||..|::|||||.|||:
Zfish    81 -----AEGDVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEK 140

  Fly   567 MDALENQLKEARFLAEEADKKYDEVARKLAMVEADLERAEERAEQGENKIVELEEELRVVGNNLK 631
            |:..|.|||||:.:|||||:||:||||||.:||.:|||.|||||..|.|..||||||:.|.||:|
Zfish   141 MELQEIQLKEAKHIAEEADRKYEEVARKLVIVEGELERTEERAELNEGKCSELEEELKTVTNNMK 205

  Fly   632 SLEVSEEKANQREEEYKNQIKTLNTRLKEAEARAEFAERSVQKLQKEVDRLEDDLVLEKERYKDI 696
            |||...||.:.:|::|:.:||.|..:|||||.|||||||||.||:|.:|.|||:|..:|.:||.|
Zfish   206 SLEAQAEKYSAKEDKYEEEIKVLTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAI 270

  Fly   697 GDDLDTAFVEL 707
            .::||.|..::
Zfish   271 SEELDHALNDM 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tm1	NP_732006.2	Tropomyosin_1	7..>85	CDD:289488
Tm1	NP_732006.2	Tropomyosin_1	517..648	CDD:289488	80/130 (62%)
tpma	NP_571180.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		9/32 (28%)
tpma	NP_571180.1	Tropomyosin	48..282	CDD:278679	129/280 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581560
Domainoid	1	1.000	245	1.000	Domainoid score	I2136
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2703
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576041at2759
OrthoFinder	1	1.000	-	-		FOG0002679
OrthoInspector	1	1.000	-	-		mtm6508
orthoMCL	1	0.900	-	-		OOG6_101961
Panther	1	1.100	-	-	O	PTHR19269
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2857
SonicParanoid	1	1.000	-	-		X463
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.930