DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tm1 and Tpm1

DIOPT Version :9

Sequence 1:	NP_732006.2	Gene:	Tm1 / 41852	FlyBaseID:	FBgn0003721	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	XP_038936768.1	Gene:	Tpm1 / 24851	RGDID:	3898	Length:	294	Species:	Rattus norvegicus

Alignment Length:	336	Identity:	142/336 - (42%)
Similarity:	209/336 - (62%)	Gaps:	60/336 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 KKKKREKGERSEKSDKSEKSDRKKKSSGKKERSKRSNPMEQSSDSLATDLSAGAIDEGIALADDD 436
            ||.:..|.::....|::|:::..||::  ::|||      |..|.|.      ::.:.:...:|:
  Rat     6 KKMQMLKLDKENALDRAEQAEADKKAA--EDRSK------QLEDELV------SLQKKLKGTEDE 56

  Fly   437 DNQAAEWSKLRCTSEAAEIVAEREARRNKGRCADYPGLAFGRSIFSSDTMMKFNIIRNELHNIMN 501
            .::.:|  .|:...|..|: ||::|                     :|
  Rat    57 LDKYSE--ALKDAQEKLEL-AEKKA---------------------TD----------------- 80

  Fly   502 TQLKRAESEVAALNRRIQLLEEDLERSEERLGSATAKLSEASQAADESERARKILENRALADEER 566
                 ||::||:|||||||:||:|:|::|||.:|..||.||.:|||||||..|::|:||..|||:
  Rat    81 -----AEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEK 140

  Fly   567 MDALENQLKEARFLAEEADKKYDEVARKLAMVEADLERAEERAEQGENKIVELEEELRVVGNNLK 631
            |:..|.|||||:.:||:||:||:||||||.::|:||||||||||..|.|..||||||:.|.||||
  Rat   141 MEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLK 205

  Fly   632 SLEVSEEKANQREEEYKNQIKTLNTRLKEAEARAEFAERSVQKLQKEVDRLEDDLVLEKERYKDI 696
            |||...||.:|:|::|:.:||.|:.:|||||.|||||||||.||:|.:|.|||:|..:|.:||.|
  Rat   206 SLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAI 270

  Fly   697 GDDLDTAFVEL 707
            .::||.|..::
  Rat   271 SEELDHALNDM 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tm1	NP_732006.2	Tropomyosin_1	7..>85	CDD:289488
Tm1	NP_732006.2	Tropomyosin_1	517..648	CDD:289488	80/130 (62%)
Tpm1	XP_038936768.1	Tropomyosin	48..282	CDD:395200	129/280 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341555
Domainoid	1	1.000	245	1.000	Domainoid score	I2112
eggNOG	1	0.900	-	-		E1_KOG1003
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	299	1.000	Inparanoid score	I2620
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576041at2759
OrthoFinder	1	1.000	-	-		FOG0002679
OrthoInspector	1	1.000	-	-		mtm8925
orthoMCL	1	0.900	-	-		OOG6_101961
Panther	1	1.100	-	-	O	PTHR19269
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X463
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800