DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tm1 and Tpm2

DIOPT Version :9

Sequence 1:	NP_732006.2	Gene:	Tm1 / 41852	FlyBaseID:	FBgn0003721	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_001264804.1	Gene:	Tpm2 / 22004	MGIID:	98810	Length:	284	Species:	Mus musculus

Alignment Length:	336	Identity:	135/336 - (40%)
Similarity:	196/336 - (58%)	Gaps:	60/336 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 KKKREKGERSEKSDKSEKSDRKKKS-SGKKERSKRSNPMEQSSDSLATDLSAGAIDEGIALADDD 436
            |||.:    ..|.||....||.::: :.||:...|...:|:...:|...|..         .:|:
Mouse     5 KKKMQ----MLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKG---------TEDE 56

  Fly   437 DNQAAEWSKLRCTSEAAEIVAEREARRNKGRCADYPGLAFGRSIFSSDTMMKFNIIRNELHNIMN 501
            ..:.:|..|     :|.|.:.:.|.:                   ::|
Mouse    57 VEKYSESVK-----DAQEKLEQAEKK-------------------ATD----------------- 80

  Fly   502 TQLKRAESEVAALNRRIQLLEEDLERSEERLGSATAKLSEASQAADESERARKILENRALADEER 566
                 ||::||:|||||||:||:|:|::|||.:|..||.||.:|||||||..|::||||:.|||:
Mouse    81 -----AEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEK 140

  Fly   567 MDALENQLKEARFLAEEADKKYDEVARKLAMVEADLERAEERAEQGENKIVELEEELRVVGNNLK 631
            |:..|.|||||:.:||::|:||:||||||.::|.:|||:|||||..|:|..:|||||::|.||||
Mouse   141 MELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESKCGDLEEELKIVTNNLK 205

  Fly   632 SLEVSEEKANQREEEYKNQIKTLNTRLKEAEARAEFAERSVQKLQKEVDRLEDDLVLEKERYKDI 696
            |||...:|.:.:|::|:.:||.|..:|||||.|||||||||.||:|.:|.||:.|...||...:|
Mouse   206 SLEAQADKYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEETLASAKEENVEI 270

  Fly   697 GDDLDTAFVEL 707
            ...||...:||
Mouse   271 HQTLDQTLLEL 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tm1	NP_732006.2	Tropomyosin_1	7..>85	CDD:289488
Tm1	NP_732006.2	Tropomyosin_1	517..648	CDD:289488	75/130 (58%)
Tpm2	NP_001264804.1	Tropomyosin	48..282	CDD:395200	122/289 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837809
Domainoid	1	1.000	248	1.000	Domainoid score	I2128
eggNOG	1	0.900	-	-		E1_KOG1003
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	301	1.000	Inparanoid score	I2662
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576041at2759
OrthoFinder	1	1.000	-	-		FOG0002679
OrthoInspector	1	1.000	-	-		mtm8688
orthoMCL	1	0.900	-	-		OOG6_101961
Panther	1	1.100	-	-	O	PTHR19269
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X463
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760