DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tm1 and Tpm1

DIOPT Version :9

Sequence 1:	NP_732006.2	Gene:	Tm1 / 41852	FlyBaseID:	FBgn0003721	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	XP_030100101.1	Gene:	Tpm1 / 22003	MGIID:	98809	Length:	326	Species:	Mus musculus

Alignment Length:	348	Identity:	145/348 - (41%)
Similarity:	213/348 - (61%)	Gaps:	42/348 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 KKKKREKGERSEKSDKSEKSDRKKKSSGKKERSKRSNPMEQSSDSLATDLSAGAIDEGIALADDD 436
            ||.:..|.::....|::|:::..||::  ::|||:          |..|::|   .|.:..|.:|
Mouse     6 KKMQMLKLDKENALDRAEQAEADKKAA--EDRSKQ----------LEEDIAA---KEKLLRASED 55

  Fly   437 DN-------QAAEWSKLRCTSEAAEIVAEREA--RRNKGRCADYPGLAFGRSIFSSDTMMKFNII 492
            :.       ..||.|.|.....||::..|..:  ::.||               :.|.:.|::..
Mouse    56 ERDRVLEELHKAEDSLLAADETAAKLEDELVSLQKKLKG---------------TEDELDKYSEA 105

  Fly   493 RNELHNIMNTQLKR---AESEVAALNRRIQLLEEDLERSEERLGSATAKLSEASQAADESERARK 554
            ..:....:....|:   ||::||:|||||||:||:|:|::|||.:|..||.||.:|||||||..|
Mouse   106 LKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMK 170

  Fly   555 ILENRALADEERMDALENQLKEARFLAEEADKKYDEVARKLAMVEADLERAEERAEQGENKIVEL 619
            ::|:||..|||:|:..|.|||||:.:||:||:||:||||||.::|:||||||||||..|.|..||
Mouse   171 VIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAEL 235

  Fly   620 EEELRVVGNNLKSLEVSEEKANQREEEYKNQIKTLNTRLKEAEARAEFAERSVQKLQKEVDRLED 684
            ||||:.|.|||||||...||.:|:|::|:.:||.|:.:|||||.|||||||||.||:|.:|.||:
Mouse   236 EEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEE 300

  Fly   685 DLVLEKERYKDIGDDLDTAFVEL 707
            .:...||....:...||...:||
Mouse   301 KVAHAKEENLSMHQMLDQTLLEL 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tm1	NP_732006.2	Tropomyosin_1	7..>85	CDD:289488
Tm1	NP_732006.2	Tropomyosin_1	517..648	CDD:289488	80/130 (62%)
Tpm1	XP_030100101.1	PRK12472	<18..>127	CDD:237110	27/138 (20%)
Tpm1	XP_030100101.1	Tropomyosin	90..324	CDD:395200	122/249 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837803
Domainoid	1	1.000	248	1.000	Domainoid score	I2128
eggNOG	1	0.900	-	-		E1_KOG1003
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	301	1.000	Inparanoid score	I2662
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576041at2759
OrthoFinder	1	1.000	-	-		FOG0002679
OrthoInspector	1	1.000	-	-		mtm8688
orthoMCL	1	0.900	-	-		OOG6_101961
Panther	1	1.100	-	-	O	PTHR19269
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2857
SonicParanoid	1	1.000	-	-		X463
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790