DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tm1 and lev-11

DIOPT Version :9

Sequence 1:	NP_732006.2	Gene:	Tm1 / 41852	FlyBaseID:	FBgn0003721	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_001021695.1	Gene:	lev-11 / 173319	WormBaseID:	WBGene00002978	Length:	284	Species:	Caenorhabditis elegans

Alignment Length:	295	Identity:	176/295 - (59%)
Similarity:	216/295 - (73%)	Gaps:	17/295 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   415 DSLATDLSAGAIDEGIALADDDDNQAAEWSKLRCTSEAAEIVAE--REARRNKGRCADYPGLAFG 477
            |::...:.|..|::..||   |...||| .|:|..:|..|.|.|  |:.::...:..|  .|...
Worm     2 DAIKKKMQAMKIEKDNAL---DRADAAE-EKVRQITEKLERVEEELRDTQKKMTQTGD--DLDKA 60

  Fly   478 RSIFSSDTMMKFNIIRNELHNIMNTQLKRAESEVAALNRRIQLLEEDLERSEERLGSATAKLSEA 542
            :...|:.|        ::|.....| ::.||:|||:||||:.||||:|||:||||..||.||.||
Worm    61 QEDLSAAT--------SKLEEKEKT-VQEAEAEVASLNRRMTLLEEELERAEERLKIATEKLEEA 116

  Fly   543 SQAADESERARKILENRALADEERMDALENQLKEARFLAEEADKKYDEVARKLAMVEADLERAEE 607
            :...|||||.||::|||:|.||||.:.:|.|||||:.||||||:|||||||||||||||||||||
Worm   117 THNVDESERVRKVMENRSLQDEERANTVEAQLKEAQLLAEEADRKYDEVARKLAMVEADLERAEE 181

  Fly   608 RAEQGENKIVELEEELRVVGNNLKSLEVSEEKANQREEEYKNQIKTLNTRLKEAEARAEFAERSV 672
            |||.|||||||||||||||||||||||||||||.|||:.|:.||:|:::||||||.|||||||||
Worm   182 RAEAGENKIVELEEELRVVGNNLKSLEVSEEKALQREDSYEEQIRTVSSRLKEAETRAEFAERSV 246

  Fly   673 QKLQKEVDRLEDDLVLEKERYKDIGDDLDTAFVEL 707
            ||||||||||||:||.||||||.|.::||:.|.||
Worm   247 QKLQKEVDRLEDELVHEKERYKTISEELDSTFQEL 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tm1	NP_732006.2	Tropomyosin_1	7..>85	CDD:289488
Tm1	NP_732006.2	Tropomyosin_1	517..648	CDD:289488	101/130 (78%)
lev-11	NP_001021695.1	Tropomyosin	48..282	CDD:278679	160/245 (65%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159706
Domainoid	1	1.000	308	1.000	Domainoid score	I732
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121635
Inparanoid	1	1.050	366	1.000	Inparanoid score	I1255
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576041at2759
OrthoFinder	1	1.000	-	-		FOG0002679
OrthoInspector	1	1.000	-	-		oto17870
orthoMCL	1	0.900	-	-		OOG6_101961
Panther	1	1.100	-	-	LDO	PTHR19269
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2857
SonicParanoid	1	1.000	-	-		X463
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.930