DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MRG15 and Arid4b

DIOPT Version :9

Sequence 1:	NP_001262588.1	Gene:	MRG15 / 41850	FlyBaseID:	FBgn0027378	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	XP_008769986.1	Gene:	Arid4b / 84481	RGDID:	619919	Length:	1319	Species:	Rattus norvegicus

Alignment Length:	494	Identity:	89/494 - (18%)
Similarity:	160/494 - (32%)	Gaps:	198/494 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 IYEAKVLKTKPDATPVEYYIHYAGWSKNWDEWVPENRVLKYNDDNV---KRRQELARQCGERSKK 97
            :|||.:..:..:...|.|.:||.||:..:|||:..:::::..|.||   |.|:::..:..:...:
  Rat   587 MYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDR 651

  Fly    98 DNKKGVYIPGSAKAKKMEQMRNESRAS---------TPSKDSNT-----------------SQST 136
            |.|   |.|.:.|.:::.:...:|..|         ..:|:|:|                 |:|:
  Rat   652 DEK---YSPKNCKLRRLSKSPFQSNPSPEMVSKLDLADAKNSDTGHIKSIEITSILNGLQASESS 713

  Fly   137 ASST----------PTTSAGPGSKSEAGSTGTT-------------------------------- 159
            |..:          |.:|:...||.|..:...:
  Rat   714 AEDSEQEEERCAQDPESSSKDESKVEHSAHSRSELISKEELSSPSLLEENKVHPDLVIAKTVSKS 778

  Fly   160 ---------------------------------TTNSTANSTTSRAHRK--STQSTPSTARPGTP 189
                                             ||:......|.|..|:  :|.....:..||..
  Rat   779 PERLRKDVEAISEDTDFEEEDEITKKRKDVKKDTTDKALKPQTKRGKRRYCNTDECLQSGSPGKK 843

  Fly   190 SD--KKEDP--------AAAETTEEE---GPVAPKKK--RMSEQRPSL------TG-SDVAEKPL 232
            .|  |.::|        ::::..|||   ..:.|.||  .:.|:|.||      :| |:||||.:
  Rat   844 EDRTKSKEPLCTGNSSNSSSDEDEEEKSKAKMTPTKKYNGLEEKRKSLRTTSFYSGFSEVAEKRI 908

  Fly   233 ------------------------------------------------PPTTTPSTPTTEPA-PC 248
                                                            ||...|...|.|.: ..
  Rat   909 KLLNNSDERLQNNRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHAAPDEGTVEESLQT 973

  Fly   249 VESEEAYAAKVEVKIKIPDELKHYLTDDWYAVVREHK-----------------LLELPAKVTVQ 296
            |..||:.:..:|::..:|..:.....::....|.:.|                 ..|.|:.|||.
  Rat   974 VAEEESCSPNMELEKPLPTSVDSKPVEEKPLEVSDRKTEFPSSGSNSVLNTPPTTPESPSSVTVT 1038

  Fly   297 QISEQYLAHKKSVKSTSASKEV-AINDVLDGIVEYFNVM 334
            :.|:|..:...||......:|| :|....|..:|..:|:
  Rat  1039 ETSQQQSSVTVSVPLPPNQEEVRSIKSETDSTIEVDSVV 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRG15	NP_001262588.1	Tudor-knot	22..75	CDD:288553	12/38 (32%)
MRG15	NP_001262588.1	MRG	249..415	CDD:283390	22/104 (21%)
Arid4b	XP_008769986.1	TUDOR	58..113	CDD:197660
		RBB1NT	169..262	CDD:285392
		ARID	311..394	CDD:198082
		Tudor-knot	571..624	CDD:288553	12/36 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3001
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900