DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MRG15 and morf4l1

DIOPT Version :9

Sequence 1:	NP_001262588.1	Gene:	MRG15 / 41850	FlyBaseID:	FBgn0027378	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001002604.2	Gene:	morf4l1 / 436877	ZFINID:	ZDB-GENE-040718-348	Length:	323	Species:	Danio rerio

Alignment Length:	412	Identity:	165/412 - (40%)
Similarity:	225/412 - (54%)	Gaps:	95/412 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DANTLFVDGERVLCFHGPLIYEAKVLKTKPDATPVEYYIHYAGWSKNWDEWVPENRVLKYNDDNV 81
            |....|.:|||||||||||:||||.:|.......|:|:|||:||:|||||||||:|||||.|.|:
Zfish     6 DPKPKFQEGERVLCFHGPLLYEAKCVKINIKDKQVKYFIHYSGWNKNWDEWVPESRVLKYVDSNL 70

  Fly    82 KRRQELARQCGERSKKDNKKGVYIPGSAKAKKMEQMRNESRASTPSKDSNTSQSTASSTPTTSAG 146
            ::::||     :::.:|:    |:.|            ..|...|||.....|.......|
Zfish    71 QKQKEL-----QKANQDH----YVEG------------RMRGVAPSKKIAAVQQKNVDVKT---- 110

  Fly   147 PGSKSEAGSTGTTTTNSTANSTTSRAHRKSTQSTPSTARPGTPSDKKEDPAAAETTEEEGPVAPK 211
                                       :|:.|.||.              |...|:..:.|..|:
Zfish   111 ---------------------------KKNKQKTPG--------------AGEGTSTGDMPHPPR 134

  Fly   212 KKRMSEQRPSLTGSDVAEKPLPPTTTPSTPTTEPAPCVESEEAYAAKVEVKIKIPDELKHYLTDD 276
            |||                            ....|.|||||.:..:||||:|||:|||.:|.||
Zfish   135 KKR----------------------------ARVDPTVESEETFINRVEVKVKIPEELKPWLVDD 171

  Fly   277 WYAVVREHKLLELPAKVTVQQISEQYLAHKKSVKSTSASKEVAINDVLDGIVEYFNVMLGSQLLY 341
            |..:.|:.:|..||||..|..:.|.|..:||| :..|.:||.|:|:|:.||.||||||||:||||
Zfish   172 WDLITRQKQLFHLPAKKNVDAVLEDYANYKKS-RGNSDNKEYAVNEVVAGIREYFNVMLGTQLLY 235

  Fly   342 KFERTQYADVMQKHPDTPLSELYGSFHLLRLFVRLGSMLSYSALDQQSMQNLLTHVQDFLKFLVK 406
            ||||.|||:::..||||.:|::||:.||||||||:|:||:|:.||::|:..||:::|||||:|||
Zfish   236 KFERPQYAEILANHPDTSMSQIYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLSYLQDFLKYLVK 300

  Fly   407 NSSIFFSMSNFINVDPEYVRNA 428
            |||..||.|::....|||.|.|
Zfish   301 NSSSLFSASDYEVAPPEYHRKA 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRG15	NP_001262588.1	Tudor-knot	22..75	CDD:288553	35/52 (67%)
MRG15	NP_001262588.1	MRG	249..415	CDD:283390	95/165 (58%)
morf4l1	NP_001002604.2	Tudor-knot	11..64	CDD:288553	35/52 (67%)
morf4l1	NP_001002604.2	MRG	135..309	CDD:283390	99/202 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583909
Domainoid	1	1.000	195	1.000	Domainoid score	I3109
eggNOG	1	0.900	-	-		E1_KOG3001
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40499
Inparanoid	1	1.050	211	1.000	Inparanoid score	I3634
OMA	1	1.010	-	-		QHG55560
OrthoDB	1	1.010	-	-		D1624495at2759
OrthoFinder	1	1.000	-	-		FOG0002343
OrthoInspector	1	1.000	-	-		oto41035
orthoMCL	1	0.900	-	-		OOG6_102009
Panther	1	1.100	-	-	LDO	PTHR10880
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R362
SonicParanoid	1	1.000	-	-		X1774
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800