DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MRG15 and htk

DIOPT Version :9

Sequence 1:	NP_001262588.1	Gene:	MRG15 / 41850	FlyBaseID:	FBgn0027378	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster

Alignment Length:	484	Identity:	103/484 - (21%)
Similarity:	169/484 - (34%)	Gaps:	151/484 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GEVKPAK--VENYSTGTDANTLFVDG-----------ERVLCFHGPLIYEAKVLKTKPDATPVEY 53
            |:.|..|  ||...||.     ||.|           ::....||. .|||||::.........|
  Fly   673 GKRKKEKISVEKIDTGD-----FVVGIGDKLKVNYHEKKSPSSHGS-TYEAKVIEISVQRGVPMY 731

  Fly    54 YIHYAGWSKNWDEWVPENRVLKYNDDNVKRRQELARQCGERSKKDNKKG---------------- 102
            .:||.||:..:|||||..|:.   ::..|..::..|.....|......|
  Fly   732 LVHYTGWNNRYDEWVPRERIA---ENLTKGSKQKTRTISTSSANSGSGGGGGGGGGGGGGGGGGG 793

  Fly   103 --VYIPGSAKAKKMEQMRNESRASTPSKDSNTSQSTASSTPTTSAGPGSKSEAGSTGTTTTNSTA 165
              :.:.||......::.        |.||..:..|.:|.   .|.|||:.|.:||.|..::..:.
  Fly   794 GSLLVQGSQPPGVSDKQ--------PGKDGCSKMSPSSG---NSTGPGAPSLSGSLGGASSTPSL 847

  Fly   166 NSTTSR----------------------------AHRKSTQS--------------TPSTARPGT 188
            .||..:                            ||...|:|              .|:...|||
  Fly   848 LSTVVKTPPTGGAKRGRGRSDSMPPRSTTPSSVVAHSGRTKSPAASQPQLQQQMKKRPTRVVPGT 912

  Fly   189 PSDKKEDPA--AAET-TEEEGPVAPKKKRMSEQRPSLTGSDVAEKPLPP---TTTPSTPTTEPA- 246
            .:.::...|  |:|: ::.:.||...|::.::.:|.      |.|..||   ....|..:|.||
  Fly   913 TTPRRVSDASMASESDSDSDEPVRRPKRQSAKDKPQ------AGKAQPPGKGRLASSASSTAPAA 971

  Fly   247 -PCVESEE---------AYAAKVEVKIKIPDELKHYLTDDWYAVV--------REHKLLEL---- 289
             |..:|||         |.||..:.:.:....|:........|:.        |::.|.|:
  Fly   972 HPSDDSEEDEEEEEPSAARAASSKQQQQQASSLRGSRAGGNRAMSSGAASAKGRDYDLSEIRSEL 1036

  Fly   290 ----PAKVTVQQISEQYLAHKKSVKSTSASKEVAINDV-----LDGIVEYFNVMLGSQL-LYKFE 344
                |..:|....:|:    :|.:.....|.|.|:.|:     |:...:..:..|.|:. .|..|
  Fly  1037 KGFQPKLLTNAASNEE----RKDLAKKEPSDEPALQDIKKEPKLESSAKSSSTELSSETESYADE 1097

  Fly   345 RTQYADVM---------QKHPDTPLSELY 364
            .:|.:|..         :|.|....|:|:
  Fly  1098 DSQSSDYRKQLKGSGAGKKEPTASPSKLH 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRG15	NP_001262588.1	Tudor-knot	22..75	CDD:288553	21/63 (33%)
MRG15	NP_001262588.1	MRG	249..415	CDD:283390	30/156 (19%)
htk	NP_573330.3	RBB1NT	171..262	CDD:285392
		ARID	299..381	CDD:279697
		Tudor-knot	692..751	CDD:288553	18/59 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1624495at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.010