DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MRG15 and arid4a

DIOPT Version :9

Sequence 1:	NP_001262588.1	Gene:	MRG15 / 41850	FlyBaseID:	FBgn0027378	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	XP_005158686.1	Gene:	arid4a / 327404	ZFINID:	ZDB-GENE-050809-105	Length:	1332	Species:	Danio rerio

Alignment Length:	408	Identity:	97/408 - (23%)
Similarity:	158/408 - (38%)	Gaps:	134/408 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 IYEAKVLKTKPDATPVEYYIHYAGWSKNWDEWVPENRVL---------KYNDDNVKRRQELARQC 91
            ||||.:..|:.|...|.|.:||.||:..:||||..:|::         |.....||.:::
Zfish   616 IYEANIKNTETDDGEVLYLVHYYGWNVRYDEWVKADRIIWPVDKGGTKKKQKKKVKNKED----- 675

  Fly    92 GERSKKDNKKGVYI-----------PGSAKAKKMEQMRNESRASTPSKDSNTSQSTASSTPTTSA 145
            .|:.|:::|..|.:           ||:::.....:.|:.|:.|.|        :.||:.|....
Zfish   676 EEKEKEEDKTKVVVRRGRPPLKSTPPGTSRKTPSSEGRSSSKNSRP--------TDASALPNGDG 732

  Fly   146 GPGSK---------SEAGSTGTTTTNSTANSTTSRAHRKS-------TQST--PSTARPGTPSDK 192
            .|..:         |:.||      |.:.||:......||       |:.|  |..|:.....|.
Zfish   733 TPRRRTRRTSGMYDSDRGS------NDSGNSSDDSEGEKSPEKKQEWTERTDPPPIAKQEAADDL 791

  Fly   193 KEDPAAAE--TTEEEGPVAPKKK---RMSEQRPS------LTGSDV------AEKPL-------P 233
            .|:....|  .||.|.|.:|::.   ..||.:|.      .|.|||      |:||.       .
Zfish   792 PEESTTQEPAQTEPELPSSPQEMPNFNESESKPEEDSSMPPTESDVGSPKMTAKKPRLKEPGSET 856

  Fly   234 PTTTPST---------PTTEPAPCVESEEA-YAAKVEVKIKIPDEL---KHYLTDDWYAVVREHK 285
            ||.||:.         |:|.|.|..:|:|. :::.|| :||:.:..   ....|:|
Zfish   857 PTQTPAAANHHAETEEPSTPPRPVKKSQETPHSSPVE-RIKLVETAGSDTDSATED--------- 911

  Fly   286 LLELPAKVTV--QQISEQ-------YLAHKKSVKSTSASKEVAINDVLDGIVEYFNVMLGSQLLY 341
             ::.|.:.:.  ::|:||       .|..|:..|:.|..|.                   |.|..
Zfish   912 -IDPPERTSAAKRKINEQRTPEKKIRLDRKEEPKTPSPVKT-------------------SPLEK 956

  Fly   342 KFERTQYADVMQKHPDTP 359
            |.|..:..:::|| |:.|
Zfish   957 KPESEKRTEIVQK-PEEP 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRG15	NP_001262588.1	Tudor-knot	22..75	CDD:288553	17/47 (36%)
MRG15	NP_001262588.1	MRG	249..415	CDD:283390	25/124 (20%)
arid4a	XP_005158686.1	TUDOR	58..113	CDD:295375
		RBB1NT	171..260	CDD:285392
		ARID	311..396	CDD:198082
		Tudor-knot	601..654	CDD:288553	17/37 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3001
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900