Protein Alignment MRG15 and MSL3

DIOPT Version :9

• Sequence 1: NP_001262588.1
• Gene: MRG15 / 41850
• FlyBaseID: FBgn0027378
• Length: 429
• Species: Drosophila melanogaster
• Sequence 2: NP_523353.2
• Gene: MSL3 / 10943
• HGNCID: 7370
• Length: 521
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 116/585 - (19%)
• Similarity: 177/585 - (30%)
• Gaps: 278/585 - (47%)

  Fly    22 FVDGERVLCFH-----GPLIYEAKVL-----KTKPDATPVEYYIHYAGWSKNWDEWVPENRVLKY 76
            |..||:||||.     ..::|:||::     |.:......||.||:.||:::||.|..|:.||:.
Human    11 FHSGEKVLCFEPDPTKARVLYDAKIVDVIVGKDEKGRKIPEYLIHFNGWNRSWDRWAAEDHVLRD 75

  Fly    77 NDDNVKRRQELARQCGE--RSKKDNKKGVYIPGSAKAKKMEQMRNESRASTPSKDSNTSQSTASS 139
            .|:|.:.:::|||:...  ||....||...:||.....|        ...|..||.|...|.:||
Human    76 TDENRRLQRKLARKAVARLRSTGRKKKRCRLPGVDSVLK--------GLPTEEKDENDENSLSSS 132

  Fly   140 TPTTSAGPGSKSEAGSTGTTTTNSTANSTTSRAHRKSTQSTPSTARPGTPSDKKEDPAAAETTEE 204
                                                              ||..|:
Human   133 --------------------------------------------------SDCSEN--------- 138

  Fly   205 EGPVAPKKKRMSEQRPSLTGSDVAEKPLPPTTTPSTPTTEPAPCVESEEAYAAKVEVKIKIPDEL 269
                  |.:.:||:      ||:.||    |.....|..:...  |.||.     .:.|:||:.|
Human   139 ------KDEEISEE------SDIEEK----TEVKEEPELQTRR--EMEER-----TITIEIPEVL 180

  Fly   270 KHYLTDDWYAVVREHKLLELPAKVTVQQISEQYLAH----------------------KKSVKST 312
            |..|.||.|.:.|..:|::||.:..:..|.|.|:.|                      ..:|...
Human   181 KKQLEDDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERPRHHHVMPHANMNVHYI 245

  Fly   313 SASKEVAI-NDVLDGIVEYFNVMLGSQLLYKFERTQYADVMQK---------------------- 354
            .|.|.|.: .:::||:...|:..|...|||.:|:.||..|...
Human   246 PAEKNVDLCKEMVDGLRITFDYTLPLVLLYPYEQAQYKKVTSSKFFLPIKESATSTNRSQEELSP 310

  Fly   355 -----HPDTP----------------------------------------LSE------------ 362
                 :|.||                                        |||
Human   311 SPPLLNPSTPQSTESQPTTGEPATPKRRKAEPEALQSLRRSTRHSANCDRLSESSASPQPKRRQQ 375

  Fly   363 ----------------------------------------------------------------- 362
                                                                             
Human   376 DTSASMPKLFLHLEKKTPVHSRSSSPIPLTPSKEGSAVFAGFEGRRTNEINEVLSWKLVPDNYPP 440

  Fly   363 ---------LYGSFHLLRLFVRLGSMLSYSALDQQSMQNLLTHVQDFLKFLVKNSSIFFSMSNFI 418
                     :||:.|||||||:|..:|...:..:::::.||.|...||:||.:....||..|.::
Human   441 GDQPPPPSYIYGAQHLLRLFVKLPEILGKMSFSEKNLKALLKHFDLFLRFLAEYHDDFFPESAYV 505

  Fly   419  418
            Human   506  505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MRG15	NP_001262588.1	Tudor-knot	22..75	CDD:288553	22/62 (35%)
		MRG	249..415	CDD:283390	61/341 (18%)
MSL3	NP_523353.2	CBD_MSL3_like	15..81	CDD:350846	23/65 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	114..166		20/136 (15%)
		MRG	156..506	CDD:399022	63/357 (18%)
		Required for the histone acetyltransferase activity of the MSL complex	290..440		6/149 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	298..409		6/110 (5%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3001
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1624495at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820