DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4338 and TSR3

DIOPT Version :9

Sequence 1:	NP_650441.1	Gene:	CG4338 / 41849	FlyBaseID:	FBgn0038313	Length:	274	Species:	Drosophila melanogaster
Sequence 2:	NP_014648.1	Gene:	TSR3 / 854167	SGDID:	S000005532	Length:	313	Species:	Saccharomyces cerevisiae

Alignment Length:	279	Identity:	112/279 - (40%)
Similarity:	149/279 - (53%)	Gaps:	41/279 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GKGKK-----GGGGPYRNVKANHNCARSFAQQANELASSSSSENESSDSESSGDGAQNDLGQPPE 66
            ||||.     ..|.|.|.                  |:..||.......|...|.::.     .:
Yeast     2 GKGKNKMHEPKNGRPQRG------------------ANGHSSRQNHRRMEMKYDNSEK-----MK 43

  Fly    67 FAV--AMWDLNHCDPKKCSGRKLARLGLISNLRLGQKFPGLVLSPVGQLCVSPLDRDVVASSGVA 129
            |.|  ||||.:|||||:|||:||.|||||.:||:||||.|:|:||.|:..|.|.|.::|...|.:
Yeast    44 FPVKLAMWDFDHCDPKRCSGKKLERLGLIKSLRVGQKFQGIVVSPNGKGVVCPDDLEIVEQHGAS 108

  Fly   130 VIDCSWAKLDETPFGRMRSPHPRLLPFLVAANPINYGKPCKLSCVEAIAATLYICGFTEEARWFL 194
            |::||||:|:|.||.::...|.||||:|||||.:|||:|.:|:||||:||...|.|..:.|...|
Yeast   109 VVECSWARLEEVPFNKIGGKHERLLPYLVAANQVNYGRPWRLNCVEALAACFAIVGRMDWASELL 173

  Fly   195 GKFSWGHAFLELNDKLLNAYAACKSSDEIVKVQNEY---LEKEQQERDKPRDLRDFY-------- 248
            ..||||..|||||.:||..|..|...|.:.:.:.|:   ||||.|||.......|.:
Yeast   174 SHFSWGMGFLELNKELLEIYQQCTDCDSVKRAEEEWLQKLEKETQERKSRAKEEDIWMMGNINRR 238

  Fly   249 PTSSSSSSSETETEGDDED 267
            ...|.|.:||:|...:..|
Yeast   239 GNGSQSDTSESEENSEQSD 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4338	NP_650441.1	Tsr3	69..233	CDD:224953	86/168 (51%)
		RLI	69..101	CDD:281988	23/33 (70%)
		DUF367	105..229	CDD:281963	57/123 (46%)
TSR3	NP_014648.1	Tsr3	34..214	CDD:224953	87/184 (47%)
		RLI	46..80	CDD:281988	23/33 (70%)
		DUF367	84..208	CDD:281963	57/123 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341606
Domainoid	1	1.000	127	1.000	Domainoid score	I1175
eggNOG	1	0.900	-	-		E1_COG2042
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I880
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004488
OrthoInspector	1	1.000	-	-		oto100122
orthoMCL	1	0.900	-	-		OOG6_101679
Panther	1	1.100	-	-	LDO	PTHR20426
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1565
SonicParanoid	1	1.000	-	-		X3182
TreeFam	1	0.960	-	-
	13	12.780