DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cp190 and ZBTB37

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001116242.1	Gene:	ZBTB37 / 84614	HGNCID:	28365	Length:	503	Species:	Homo sapiens

Alignment Length:	679	Identity:	130/679 - (19%)
Similarity:	215/679 - (31%)	Gaps:	242/679 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 CDLTLQFRDNSQLKVHRLVLSACTDYFN---VLEQTCEIVDDALIMPNEFQADVVVPIVNFMYTG 91
            ||:.:..:..: .:.|::||:|.:.||.   .|.:...:....:..|..|:     .:::|.|||
Human    32 CDIVVNVQGQA-FRAHKVVLAASSPYFRDHMSLNEMSTVSISVIKNPTVFE-----QLLSFCYTG 90

  Fly    92 TLEFELKMYGKLLRTAKEMNMTVLL----KLLEA-HRR----------TMENVNRQQRPPSPKGI 141
            .:..:|......|..|..:.|..::    ::||. |.:          :......|:|||.
Human    91 RICLQLADIISYLTAASFLQMQHIIDKCTQILEGIHFKINVAEVEAELSQTRTKHQERPPE---- 151

  Fly   142 RRRTVGQPSSGLPQQRVLGPSPQSRNVATPIAQRANTQRGSTGNTMSRTSGGSNRSPYGDSSNVK 206
                         ..||      :.|:...::.|.||.:|:....:|........||       .
Human   152 -------------SHRV------TPNLNRSLSPRHNTPKGNRRGQVSAVLDIRELSP-------P 190

  Fly   207 QEPTSPFEQLRKGYNNNKRPAQTSLLSPPSKKPSLEEVKEF--AEQQRMRKQIAAEYGDNDPEYD 269
            :|.|||                 .::.|.|...|.|.:...  |.|..:...:|...|.:|.|.
Human   191 EESTSP-----------------QIIEPSSDVESREPILRINRAGQWYVETGVADRGGRSDDEV- 237

  Fly   270 GGMLYDDVHAGDDDDDDMPPQPSTSKQQSPQGTQTQLEHGSTTIILKQDSPSQTPTIIVKDSSNA 334
              .:...||...::.::.     ...:..|.|                           :|.|:|
Human   238 --RVLGAVHIKTENLEEW-----LGPENQPSG---------------------------EDGSSA 268

  Fly   335 KLNHTKIIAEVLRQYPHIVKGHKNIKLKIMPNTPAAPTEKSAPATVKPPANQSSATTSPHKKLHV 399
            :    ::.|.|:....|...|.:|..|            .|:.|.|..|.:......||
Human   269 E----EVTAMVIDTTGHGSVGQENYTL------------GSSGAKVARPTSSEVDRFSP------ 311

  Fly   400 SFKADKSTPLITAQQKAASSQQKSGTSQTTGNQGTGANPPANTAAAQKRRIDSKTMHALIAQGAE 464
               :....||         :::....|::.|.......|.:        :::...|
Human   312 ---SGSVVPL---------TERHRARSESPGRMDEPKQPSS--------QVEESAM--------- 347

  Fly   465 NTTGPWLCLRCGVNG-----RPISIPSYRGFRRHLINTHKETIDPAL-CEHCGWRSVN-----NR 518
                      .||:|     |...: |.|.||          .:|.| |.:|. :|.|     :|
Human   348 ----------MGVSGYVEYLREQEV-SERWFR----------YNPRLTCIYCA-KSFNQKGSLDR 390

  Fly   519 ELHFHMYMEHQTKSLLYTFAECALCNQSYRTKGELEAHINEVHTDDNKQQCIYCNKVFEQELQLY 583
            .:..||.:         |...|.:|.:.|..|.:||.||.: ||.:....|..|.|.|..:..|.
Human   391 HMRLHMGI---------TPFVCRMCGKKYTRKDQLEYHIRK-HTGNKPFHCHVCGKSFPFQAILN 445

  Fly   584 RHMKSYHKEQALEDGIIDETDEEFLGSQDEEEEAEGDEEQEPEQTGKVRILSDISLPATSAITVQ 648
            :|.:..|      .|.|               ..||.....||               |:..:..
Human   446 QHFRKNH------PGCI---------------PLEGPHSISPE---------------TTVTSRG 474

  Fly   649 QAQQEQ-LQEEDV---EQVQQEVKFVGAD 673
            ||::|. .|||.|   |.||..|...|.|
Human   475 QAEEESPSQEETVAPGEAVQGSVSTTGPD 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	21/99 (21%)
		BTB	31..127	CDD:197585	21/113 (19%)
		C2H2 Zn finger	540..568	CDD:275371	10/27 (37%)
		C2H2 Zn finger	569..586	CDD:275371	5/16 (31%)
ZBTB37	NP_001116242.1	BTB_POZ_ZBTB37	7..129	CDD:349531	22/102 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..206		20/112 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..344		15/101 (15%)
		C2H2 Zn finger	375..395	CDD:275368	5/20 (25%)
		zf-H2C2_2	387..412	CDD:404364	7/33 (21%)
		zf-C2H2	401..423	CDD:395048	8/22 (36%)
		C2H2 Zn finger	403..423	CDD:275368	8/20 (40%)
		zf-H2C2_2	416..438	CDD:404364	9/22 (41%)
		C2H2 Zn finger	431..449	CDD:275368	6/17 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	457..503		17/60 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000