DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cp190 and Zbtb42

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001119774.1	Gene:	Zbtb42 / 691556	RGDID:	1582758	Length:	420	Species:	Rattus norvegicus

Alignment Length:	622	Identity:	118/622 - (18%)
Similarity:	187/622 - (30%)	Gaps:	261/622 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GVFFLQKLQNFFNKTDYCDLTLQFRDNSQLKVHRLVLSACTDYFNVL--EQTCEIVDDALIMPNE 75
            ||..|.:|:........||.|:...| ::...||.||:||:.||::.  :|.....|..     .
  Rat     7 GVRLLGRLRQQRELGFLCDCTVLVGD-ARFPAHRAVLAACSVYFHLFYRDQPASSRDTV-----R 65

  Fly    76 FQADVV-VP----IVNFMYTGTLEFELKMYGKLLRTAKEMNMTVLLKLLEAHRRTMENVNRQQRP 135
            ...|:| ||    :::|||.|.|:........:|..|..::|..::|:.:...|        ::.
  Rat    66 LNGDIVTVPAFSRLLDFMYEGRLDLHSLPVEDVLAAASYLHMYDIVKVCKGRLR--------KKD 122

  Fly   136 PSPKGIRRRTVGQPSSGLPQQRVLGPSPQSRNVATPIAQRANTQRGSTGNTMSRTSGGSNRSPYG 200
            |.   :..||:|   :.||.|.   |.|.
  Rat   123 PD---LETRTLG---TELPGQT---PHPL------------------------------------ 142

  Fly   201 DSSNVKQEPTSPFEQLRKGYNNNKRPAQTSLLSPPSKKPSL-----EEVKEFAEQQRMRKQIAAE 260
                    |:.|             ||... .:|.:|.|||     ..:.:|.
  Rat   143 --------PSWP-------------PAFCQ-ATPKAKPPSLGVKAVHPLPKFG------------ 173

  Fly   261 YGDNDPEYDGGMLYDDVHAGDDDDDDMPPQPSTSKQQSPQGTQTQLEHGSTTIILKQDSPSQTPT 325
                                       ||....|::.|
  Rat   174 ---------------------------PPSWQVSEESS--------------------------- 184

  Fly   326 IIVKDSSNAKLNHTKIIAEVLRQYPHIVKGHKNIKLKIMPNTPAAPTEKSAPATVKPPANQSSAT 390
                                         |..::.||     |....|::.|    |...|:|..
  Rat   185 -----------------------------GALDLSLK-----PGPRPEQAHP----PCLLQTSQC 211

  Fly   391 TSPHKKLHVSFKADKSTPLITAQQKAASSQQKSGTSQTTGNQGTGANPPANTAAAQKRRIDSKTM 455
            :|..:         .:.||:.|:|.:.|.|..|.......:.     ||...:||:...::.:.:
  Rat   212 SSIQQ---------GAQPLVKAEQDSFSEQDSSSPQSADRSP-----PPVCASAARGLAVNLEPL 262

  Fly   456 HALIAQGAENTTGPWLCLRCGVNGRPISIPSYRGFRRHLI----------NTHKETIDPALCEHC 510
            |   .||    ||   ..:.|::..|:......|..|||.          :||  .:.|.|..|.
  Rat   263 H---IQG----TG---SQQLGLHAEPVVDSEDLGPGRHLCICPLCCKLFPSTH--ALQPHLSAHF 315

  Fly   511 GWR-SVNNRELHFHMYME---------HQTKSLLYTFAE------------CALCNQSYRTKGEL 553
            ..| ||..|     :..|         .:|.|..||...            |..|.:|::....|
  Rat   316 RERDSVRTR-----LSPEGAVPTCPLCSKTFSCTYTLKRHERTHSGEKPYTCVQCGKSFQYSHNL 375

  Fly   554 EAHINEVHTDDNKQQCIYCNKVFEQELQLYRHMKSYH 590
            ..|. .|||.:....|.:|.:.|.|...||||::.:|
  Rat   376 SRHA-VVHTREKPHACRWCERRFTQSGDLYRHVRKFH 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	28/108 (26%)
		BTB	31..127	CDD:197585	27/102 (26%)
		C2H2 Zn finger	540..568	CDD:275371	8/27 (30%)
		C2H2 Zn finger	569..586	CDD:275371	7/16 (44%)
Zbtb42	NP_001119774.1	BTB_POZ_ZBTB42	1..129	CDD:349737	33/138 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..204		10/94 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..248		9/45 (20%)
		C2H2 Zn finger	294..314	CDD:275368	4/21 (19%)
		COG5048	334..>388	CDD:227381	12/54 (22%)
		C2H2 Zn finger	334..354	CDD:275368	4/19 (21%)
		zf-H2C2_2	347..369	CDD:404364	2/21 (10%)
		C2H2 Zn finger	362..382	CDD:275368	5/20 (25%)
		C2H2 Zn finger	390..408	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24394
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100