DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cp190 and Rp1

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	XP_008761780.1	Gene:	Rp1 / 681377	RGDID:	1596713	Length:	2150	Species:	Rattus norvegicus

Alignment Length:	1263	Identity:	240/1263 - (19%)
Similarity:	431/1263 - (34%)	Gaps:	354/1263 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGEVKSVKVDNWGVFFLQKLQNFFNKTDYCDLTLQFRDNSQLKVHRLVLSACTDYFNVLEQTCEI 65
            :||::..:.......||.      :::..|:..|:    .|..:|         .|:.||:
  Rat   792 IGELRKQETGQEDKVFLH------SESKLCESNLE----KQSLLH---------VFSSLEE---- 833

  Fly    66 VDDALIMPNEFQADVV------------VPIVNFMYTGTLEFELKMYGKLLR---TAKEMNMTV- 114
             |...:..::.|.:.|            ||.||.::. |:..:.|..|..|:   |..|.::..
  Rat   834 -DQKALHRSQSQVETVTENWKGMTKKSLVPKVNDLHV-TVRNQRKQKGVKLKSGATVSEQHIATR 896

  Fly   115 -----------LLKLLEAH------RRTMENVNR----QQRPPSPKG-IRRRTVGQPSSGLPQQR 157
                       |.:.:..|      :|.::|:|.    :.|..:|.| .|...|...|:|.|:..
  Rat   897 ADPLASLKKPDLTEGIPHHSVKSYIQRWLQNINPYPDFEHRKSAPLGQDRSNVVNYNSNGFPENN 961

  Fly   158 VLGPSPQSRNVATPIAQRANTQRGSTGNTMSRTSGGSNRSPYGDSSNVKQEPTSPFEQLRKGY-- 220
            :...|.:.::......:|........||....||........|:..| |....|..|.|...|
  Rat   962 LPTTSSKGKSFLMESNKRKTKNANWKGNKNQETSKSLVVKDNGEQPN-KHSCESQDESLYDSYLG 1025

  Fly   221 --NNNKRPAQTSLLSPPSK-----KPSLEEVKEFAEQ-----QRMRKQIAAE---YGDNDPEYDG 270
              ::|...:|||:..|.:|     :.|..|||...::     :|...::|.:   .|:|.|:...
  Rat  1026 PLHDNCTLSQTSINDPCTKSHLSTEKSRPEVKLVYQEMNFSTKRQTLEVAIQVDTMGENVPKDLL 1090

  Fly   271 GMLYDDVHAGDDDDDDMPPQPSTSKQQSPQGTQTQLEHGSTTIILKQDSPSQTPTIIVKDSSNAK 335
            .:|...:.|            .....|..|...:||......::.        |:.|...|:|..
  Rat  1091 ALLLQHLEA------------FIPNNQKHQNGISQLPGSLAEVVF--------PSAIYNSSTNLL 1135

  Fly   336 LNHTKIIAEVLRQYPHIVKGHKNIKLKIMPNTPAAPTEKSAPATVKPPANQSSATTSPHKKLHVS 400
            |....::               |:|..:     .:..:..||.|.. .:::::|.....|.:.::
  Rat  1136 LAWLLVL---------------NLKRNM-----NSFCQSDAPKTTS-RSSETAALLDVLKHVAIT 1179

  Fly   401 FKADKSTPLITAQQKAASSQQKSGTSQTTGNQGTGAN-PPANTAAAQKRRID-----SKTMHALI 459
            .:||        ..|||.:.....|...:|..|...: .|||..||....:|     ..|..:|:
  Rat  1180 EEAD--------DLKAAVANLVESTKTCSGPSGREQDTAPANCIAASLHSVDKCKENKSTQKSLL 1236

  Fly   460 AQG--AENTTGPWLCLRCGVNGRPISIPSYRGFRRHLINTHKETIDPALCEHCGWRSVNNRELHF 522
            .:|  .....||.||:...|: :..:.||    ..|.::.   |..|        :.|||:
  Rat  1237 DEGYSVRGDCGPELCVLEMVS-KSNNTPS----EGHTVSM---TYPP--------KGVNNQ---- 1281

  Fly   523 HMYMEHQTKSLLYTFAECALCNQSYRTKGELEAHINEVHTDDNKQQCIYCNKVFEQELQLYRHMK 587
                    ...|:|      .|.| .|..:...|                |..|..|..|.....
  Rat  1282 --------NDALFT------SNDS-STMSQRSTH----------------NASFLGEACLLTDSL 1315

  Fly   588 SYHKEQALEDGIIDE---TDE-----------EFLGSQDEEEEAEGDEEQEPEQTGKV----RIL 634
            ..||..|.:|.|.:.   :||           ||:.|::.:.....:..:|.:...||    .||
  Rat  1316 CSHKACAQKDNIYEAACLSDETHIPIRDCKTIEFVNSKENKCTDNLELTEEIKTVDKVPKDLNIL 1380

  Fly   635 --------SDISLPATSAITVQQAQQ-------------------EQLQEEDVEQVQQEVKFVGA 672
                    ||||   ||:..|.:...                   |:.|....:::..:.|.|.:
  Rat  1381 ADSIDKNESDIS---TSSQNVNKLSSQGIFLSKTHLDSDKDYSPLEEFQNCPPKKIVNKKKSVSS 1442

  Fly   673 DGNEVELTDEQRKEILSQLNQQQAGATAGGVVMVLSEPEAE-----HVKQETDEKSLAGTEEEYD 732
            | .|...|.|:.:.|.:.:...:..||:  .:....|.|::     ::|..|:||:...:.::..
  Rat  1443 D-KEDSRTSEEPRSITNSVTSSERNATS--ELESFEESESQDTGIFNMKVRTEEKAAKESMQKES 1504

  Fly   733 DSQIYSEL---GAADSVESAKKNIA-------------------DESKES--------------- 760
            ::::..||   ...:.:|..::|.|                   |.:|.:
  Rat  1505 EARMSLELINISGRNIIEQGRRNTAFLETTGRGQVTPPSLVFCYDSNKNTEKEMSVGETKMRVKK 1569

  Fly   761 -IDNLEWAENLIAESEEQSNKEPKSDKPRDDISEKLKELTGDWTEDENDDDVDDKPATAELASEL 824
             :|::|  .....:|....||:.:|..            |.||: |...|.....|..|     |
  Rat  1570 IVDSME--NESYTDSSLNCNKQHRSPG------------TLDWS-DYGSDSESRYPCKA-----L 1614

  Fly   825 ANKDPEPTVHEEEDDIDLALQSLHK--GPEEATEEKASEESVTSAD----DAVDAVPNI-NSQPE 882
            :.:..:.|..|.|....:..:::.|  |..|..:......|:..:.    :.|: ||.: .:...
  Rat  1615 SYEHSDDTGQEREYPRGIVRRAIEKLYGKAEIIKPPFFHGSIHKSQVCPYNPVE-VPCVKKTHFY 1678

  Fly   883 KMDVDSEAADEKASKAEVQIKKEAELENDQEEFIKEDSPIPHSDSVAELR-EAVTASEGEDDVHL 946
            :.:..|..:.|:.|::.:.      |:..|||...|.......||..:.. |.||.......|.:
  Rat  1679 ESECQSLVSSEQVSRSSLM------LQEFQEERQSEVDANGMGDSFGDSSIEKVTKPSEHGRVFM 1737

  Fly   947 EADNIRKELLDE---LIAEAEKPDQEKDIVQSEENATTEALDRSVTDED----------DLVP-P 997
            |.:  :.:|:|.   |:.|........|......||.|.::| ::.|::          :|.| |
  Rat  1738 EKE--KGKLIDNGKWLLRENHLWRVSLDNPGMYGNADTTSVD-TLMDKNSIEVPYSHFGELAPGP 1799

  Fly   998 TQVSTEQMEIDE--------------PAAEKAAENNEDTRTADEKEAVEDK-PNQTQDVTTAEKP 1047
            |.......||:|              |....:....||...|......::| ||..::    ||.
  Rat  1800 TMAELSSSEIEEMTQPLEVKCNYFNFPHGSDSEPFGEDFLDAQNTNCPKEKIPNHHKE----EKR 1860

  Fly  1048 TLESAKAGDEATSGEAASVDKVKSLISE 1075
            ...|.:.....|...|::.:||..:.|:
  Rat  1861 NSPSERTCTPVTQTFASAGNKVHPVCSD 1888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	21/128 (16%)
		BTB	31..127	CDD:197585	22/128 (17%)
		C2H2 Zn finger	540..568	CDD:275371	4/27 (15%)
		C2H2 Zn finger	569..586	CDD:275371	4/16 (25%)
Rp1	XP_008761780.1	DCX	60..135	CDD:176357
Rp1	XP_008761780.1	DCX	182..257	CDD:176357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900