DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cp190 and Zbtb18

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	XP_006250390.1	Gene:	Zbtb18 / 64619	RGDID:	621548	Length:	531	Species:	Rattus norvegicus

Alignment Length:	720	Identity:	117/720 - (16%)
Similarity:	212/720 - (29%)	Gaps:	301/720 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QKLQNFFNKTDYCDLTLQFRDNSQLKVHRLVLSACTDYFNVLEQTCEIVDDALIMPNEFQADVVV 82
            |:.|.|.     ||.|:...| :|.:.||.||::|:.||::..:  :.:|...|:  ...:|:|.
  Rat    26 QRHQGFL-----CDCTVLVGD-AQFRAHRAVLASCSMYFHLFYK--DQLDKRDIV--HLNSDIVT 80

  Fly    83 P-----IVNFMYTGTLEFELKMYGKLLRTAKEMNMTVLLKL----LEAHRRTMENVNRQQRPPSP 138
            .     ::.|||.|.|:|:......:|..|..::|..::|:    |:....|..:..:::...|.
  Rat    81 APAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATTEADSTKKEEDASS 145

  Fly   139 KGIRRRTVGQPSSG-------------------LPQQRVLGPSPQSRNVATPIAQRANTQRGSTG 184
            ...:..::...||.                   ||.:|.|...|.:..:..|.......|.|...
  Rat   146 CSDKVESLSDGSSHMAGDLPSDEDEGEDDKLNILPSKRDLAAEPGNMWMRLPSDAAGIPQAGGEA 210

  Fly   185 NTMSRTSGGSNRSPYGDSSNVKQEPTSPFEQLRKGYNNNKRPAQTSLLSPPSKKPSLEEVKE--- 246
            ...:..:|.:..||...:.::.|          :...:.:..|....:...|.|.||..|:.
  Rat   211 EPHATAAGKTVASPCSSTESLSQ----------RSVTSVRDSADVDCVLDLSVKSSLSGVENLNS 265

  Fly   247 --FAEQQRMRKQIA------------AEYGDNDPEYD-------------GGMLYDDVHAGDDDD 284
              |:.|..:|..:.            ::.|.||  ||             ..:.|:..|.....:
  Rat   266 SYFSSQDVLRSNLVQVKVEKEASCDESDVGTND--YDMEHSTVKESVSANNRVQYEPAHLAPLRE 328

  Fly   285 D------DMPPQPSTSKQQSPQGTQTQLEHGSTTIILKQDSPSQTPTIIVKDSSNAKLNHTKIIA 343
            |      |...:.|..:..:|:..:.|:|.|..:.:|
  Rat   329 DSVLRELDREDKASDDEMMTPESERVQVEGGMESSLL---------------------------- 365

  Fly   344 EVLRQYPHIVKGHKNIKLKIMPNTPAAPTEKSAPATVKPPANQ-------SSATTSPH-KKLHVS 400
                  |::                         :.:..||.|       :....||| .::|:|
  Rat   366 ------PYV-------------------------SNILSPAGQIFMCPLCNKVFPSPHILQIHLS 399

  Fly   401 FKADKSTPLITAQQKAASSQQKSGTSQTTGNQGTGANPPANTAAAQKRRIDSKTMHALIAQGAEN 465
                                     :......|..:.|.|:
  Rat   400 -------------------------THFREQDGIRSKPAAD------------------------ 415

  Fly   466 TTGPWLCLRCGVNGRPISIPSYRGFRRHLINTHKETIDPALCEHCGWRSVNNRELHFHMYMEHQT 530
                            :::|:                    |..||                 :|
  Rat   416 ----------------VNVPT--------------------CSLCG-----------------KT 427

  Fly   531 KSLLYTFAE------------CALCNQSYRTKGELEAHINEVHTDDNKQQCIYCNKVFEQELQLY 583
            .|.:||...            |..|.:|::....|..|. .|||.:....|.:|.:.|.|...||
  Rat   428 FSCMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHA-VVHTREKPHACKWCERRFTQSGDLY 491

  Fly   584 RHMKSYHKEQALEDGIIDETDEEFLGSQDEEEEAEGDEEQEPEQTGKVRILSDISLPATSAITVQ 648
            ||::.:|.              |.:.|...:.||                   :|||.....|::
  Rat   492 RHIRKFHC--------------ELVNSLSVKSEA-------------------LSLPTVRDWTLE 523

  Fly   649 QAQQE 653
            .:.||
  Rat   524 DSSQE 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	29/110 (26%)
		BTB	31..127	CDD:197585	27/104 (26%)
		C2H2 Zn finger	540..568	CDD:275371	8/27 (30%)
		C2H2 Zn finger	569..586	CDD:275371	7/16 (44%)
Zbtb18	XP_006250390.1	BTB_POZ_ZBTB18_RP58	10..156	CDD:349633	32/139 (23%)
		COG5048	<360..>490	CDD:227381	33/291 (11%)
		C2H2 Zn finger	381..401	CDD:275368	5/44 (11%)
		C2H2 Zn finger	421..441	CDD:275368	7/36 (19%)
		zf-H2C2_2	434..456	CDD:404364	2/21 (10%)
		C2H2 Zn finger	449..469	CDD:275368	5/20 (25%)
		C2H2 Zn finger	477..495	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24394
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100