DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cp190 and RP1

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	XP_016869210.1	Gene:	RP1 / 6101	HGNCID:	10263	Length:	2163	Species:	Homo sapiens

Alignment Length:	1309	Identity:	240/1309 - (18%)
Similarity:	415/1309 - (31%)	Gaps:	455/1309 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 NKTDYCDLTLQFRDNSQLKVHRLVLSACTDYFNVLEQTCEIVDDALIMPNEF-----QADVVVPI 84
            |::.||..|  |.:.|...|           ||:|||          .|.:|     ||:|....
Human   812 NESKYCKST--FENKSLFHV-----------FNILEQ----------KPKDFYAPQSQAEVASGY 853

  Fly    85 VNFMYTGTL-----EFELKMYGKLLRTAKEMNMTVLLKLLEAHRRTMEN-VNRQQRPPSPKGIRR 143
            :..|...:|     :..:.:..:..|...::..:.:|.  :.|..|..| :...::|..|:.|..
Human   854 LRGMAKKSLVSKVTDSHITLKSQKKRKGDKVKASAILS--KQHATTRANSLASLKKPDFPEAIAH 916

  Fly   144 RTVG-------QPSSGLPQQRVLGPSPQSRNVATPIAQRANTQRGSTGNT--------------- 186
            .::.       |..:..|..:.:..:|..||..:.:....|:..|:..:|
Human   917 HSIQNYIQSWLQNINPYPTLKPIKSAPVCRNETSVVNCSNNSFSGNDPHTNSGKISNFVMESNKH 981

  Fly   187 MSRTSG--GSNRSPYGDSSNVKQEP-TSPFEQLRKGYNNNKRPAQTSLLSPPSKKPSLEEVKEFA 248
            :::.:|  |.|....||.|.:..:. .....:.:.|..|:      :.|.|..:..:|.:  ...
Human   982 ITKIAGLTGDNLCKEGDKSFIANDTGEEDLHETQVGSLND------AYLVPLHEHCTLSQ--SAI 1038

  Fly   249 EQQRMRKQIAAEYGDNDPEYDGGMLYDD---------VHAGDDDDDDMPPQPSTSKQQSPQGTQT 304
            .....:..||||  .:.||..  ::|.:         |.|....|   |.:..|.|...|.....
Human  1039 NDHNTKSHIAAE--KSGPEKK--LVYQEINLARKRQSVEAAIQVD---PIEEETPKDLLPVLMLH 1096

  Fly   305 QLEHGSTTIILKQDSPSQTP-------------------------TIIVKDSSNA---------- 334
            ||:.....|...|:...|.|                         .:.:|.|.|:
Human  1097 QLQASVPGIHKTQNGVVQMPGSLAGVPFHSAICNSSTNLLLAWLLVLNLKGSMNSFCQVDAHKAT 1161

  Fly   335 -KLNHTKIIAEVLRQYPHIVKGHKNIKLKIMPNTPAAPTEKS--APATVKPPANQSSATTS---- 392
             |.:.|..:.|:|:   ||                 |.||::  ..|.|   ||...:|||
Human  1162 NKSSETLALLEILK---HI-----------------AITEEADDLKAAV---ANLVESTTSHFGL 1203

  Fly   393 ---PHKKLHVSFKADKSTPLITAQQKAASSQQKSGTSQTTGNQGTGANP---------------- 438
               ....:.:...|:.||..|.:..|.:.:::..|.|...|  |..|:.
Human  1204 SEKEQDMVPIDLSANCSTVNIQSVPKCSENERTQGISSLDG--GCSASEACAPEVCVLEVTCSPC 1266

  Fly   439 ---PANTAAAQKRRID-SKTMHALIAQGAENTTGPWLCL-------------------------- 473
               ..|.|.:.|...: |.|.......|.:.|:....|.
Human  1267 EMCTVNKAYSPKETCNPSDTFFPSDGYGVDQTSMNKACFLGEVCSLTDTVFSDKACAQKENHTYE 1331

  Fly   474 -RCGVNGR--PISIPSYRGFRRHLINTHKETIDPALCEHCGWRSVNNRELH-------------- 521
             .|.::..  |:::.:...|.....||:.:.:|            :..||.
Human  1332 GACPIDETYVPVNVCNTIDFLNSKENTYTDNLD------------STEELERGDDIQKDLNILTD 1384

  Fly   522 ------FHMYMEHQTKSLLYTFAECALCNQSYRTKGELEAHINEVHTD-DNKQQCIYCNKVFEQE 579
                  |:..:.||..|.|   :.|.||      ..|.||.:::.|:. |:.:.|
Human  1385 PEYKNGFNTLVSHQNVSNL---SSCGLC------LSEKEAELDKKHSSLDDFENC---------- 1430

  Fly   580 LQLYRHMKSYHKEQALEDGIIDE--TDEE-------FLGSQDEEEEAEGDEEQEPEQTGKVRILS 635
                 .::.:..|.|.....::|  |.||       ...|:....|.|..||.|...|
Human  1431 -----SLRKFQDENAYTSFDMEEPRTSEEPGSITNSMTSSERNISELESFEELENHDT------- 1483

  Fly   636 DISLPATSAITVQQAQQEQLQEEDVEQVQQEVKFVGADGNEVELTDEQRKEILSQLNQQQAGATA 700
            ||.....:.  .:||.:|.:||| ||.           ...:||.|...|.|:
Human  1484 DIFNTVVNG--GEQATEELIQEE-VEA-----------SKTLELIDISSKNIM------------ 1522

  Fly   701 GGVVMVLSEPEAEHVKQETDEKSLAGTEEEYDDSQIYSELGAADSVE---SAKKNIADESKESID 762
                               :||.:.|...|.    |...|....|::   .:|:|...|:.|.
Human  1523 -------------------EEKRMNGIIYEI----ISKRLATPPSLDFCYDSKQNSEKETNEG-- 1562

  Fly   763 NLEWAENLIAESEEQSNKEPKSDKPRDDISEKLKE-LTGDWTEDENDDDVDDKPATAELASELAN 826
            ..:..:.::...|..|..|..     .|:.:.:|. :|.||::...|.|       :|...:.::
Human  1563 ETKMVKMMVKTMETGSYSESS-----PDLKKCIKSPVTSDWSDYRPDSD-------SEQPYKTSS 1615

  Fly   827 KDPEPT---VHEEEDDIDLALQSLHK----------------------GPEEATEEKASEES--V 864
            .||..:   ..|:|.:|....:::.|                      .|..:.|.:.|.::  .
Human  1616 DDPNDSGELTQEKEYNIGFVKRAIEKLYGKADIIKPSFFPGSTRKSQVCPYNSVEFQCSRKASLY 1680

  Fly   865 TSADDAVDAVPNINSQPEKMDVDSEAADEKASKAEVQIKKEAELENDQEEFIKEDSPIPHSDS-- 927
            .|...:..:...::|....:   .|..:|:..|.:|...::.....|    |.|.....:.||
Human  1681 DSEGQSFGSSEQVSSSSSML---QEFQEERQDKCDVSAVRDNYCRGD----IVEPGTKQNDDSRI 1738

  Fly   928 VAELREAVTASEGEDDVHLEADNIRKELLDE---LIAEAEKPDQEKDIVQSEENATTEALDRSVT 989
            :.::.|.|...:|            |.||.|   |...:|.|..       ..||.|.::|..:.
Human  1739 LTDIEEGVLIDKG------------KWLLKENHLLRMSSENPGM-------CGNADTTSVDTLLD 1784

  Fly   990 DEDDLVP----------PTQ---VSTEQMEIDEPA--------------AEKAAENNEDTRT--- 1024
            :....||          ||.   .|:|..|:.:|.              :|...|:..|.|.
Human  1785 NNSSEVPYSHFGNLAPGPTMDELSSSELEELTQPLELKCNYFNMPHGSDSEPFHEDLLDVRNETC 1849

  Fly  1025 ADEKEA---VEDK-PNQTQDVTTAEKPTLESA-----KAGDEA--------------TSGEAASV 1066
            |.|:.|   .|:| .:|::.|.|:...:..||     ...|:|              |..||.|:
Human  1850 AKERIANHHTEEKGSHQSERVCTSVTHSFISAGNKVYPVSDDAIKNQPLPGSNMIHGTLQEADSL 1914

  Fly  1067 DKVKSLISE 1075
            ||:.:|..:
Human  1915 DKLYALCGQ 1923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	21/106 (20%)
		BTB	31..127	CDD:197585	20/105 (19%)
		C2H2 Zn finger	540..568	CDD:275371	8/28 (29%)
		C2H2 Zn finger	569..586	CDD:275371	1/16 (6%)
RP1	XP_016869210.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900