DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cp190 and zbtb40

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	XP_005172972.1	Gene:	zbtb40 / 571158	ZFINID:	ZDB-GENE-030131-1704	Length:	1061	Species:	Danio rerio

Alignment Length:	1185	Identity:	219/1185 - (18%)
Similarity:	380/1185 - (32%)	Gaps:	396/1185 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VKVDNWGVFFLQKLQNFFNKTDYCDLTLQFRDNSQLKVHRLVLSACTDYF-NVLEQTCEI-VDDA 69
            :::.|:....:|:|.....:..:||.::...:... ..|:|||:|.:..| :|||.:..| :|..
Zfish     1 MELPNYSRQLMQQLHTLRKEKKFCDCSILVSETPH-PAHKLVLAASSLLFKSVLESSDSISIDTD 64

  Fly    70 LIMPNEFQADVVVPIVNFMYTGTLEFELKMYGKLLRTAKEMNM-----------TVLLKLLE--- 120
            |:...||.:     :::.:|||.|........:|:..|..:.|           |.|:|..|
Zfish    65 LLSSQEFSS-----LLDLVYTGKLPPGKHNLTRLIAAADSLQMFDVAVGCKNILTDLMKQTEPID 124

  Fly   121 ----AHRRTMENVNRQQR-----------PPSPKGI-----------------------RRRTV- 146
                .....:|.|.|::|           .....|:                       .|:.:
Zfish   125 PQVIKPDSVVEQVKREERNLQEDNAVEMISHDRAGLMKILQRGKSHVQFLEAWDAVSTEERQVIL 189

  Fly   147 ----GQPSSG---------LPQQRVLGPSPQSRNVATPI----------------AQRANTQRGS 182
                |.||:.         |..:|||    .|:.|.|.:                :|..:|.:||
Zfish   190 EMFRGDPSADELYQRLLNLLEVERVL----SSKTVLTLLEQLKHSDLEEQGDQSCSQPKDTVQGS 250

  Fly   183 TGNTMSRTSGGSNRSPYGDSSNVKQEPTSPFEQLRKGYNNNKRPAQTSLLSPPSKKPSLE----- 242
            :| .:.|.|..::.  ....:|:.:..||   .:.|..|..::.|.....|.||....||
Zfish   251 SG-ILERLSEVTHH--LSSVNNLSEILTS---AVTKCTNQVEKEALLQCCSAPSSAEVLENLLCK 309

  Fly   243 ----------------EVKEFAE-----------------------------QQRMRK------- 255
                            ||||.:.                             |.|:.:
Zfish   310 LREMSISEETFLILLNEVKEKSTDLLQLLETLKNTRGVTTKESNAVDLLGMYQSRLVELNLDLQL 374

  Fly   256 -----QIAAEYGDNDPEYDGGMLYDDVHAGDDDDDDMPPQPSTSKQQSPQGTQ-------TQLEH 308
                 |:..|..:||.:...|:|.:..     |.:........:...|.|...       |:..:
Zfish   375 IKQSLQMGPEMPENDRQCIEGLLVEKA-----DAEVFERLILAALDGSLQAVTAWRILFWTETHN 434

  Fly   309 GSTTII---LKQDSPSQTPTIIVKDSSNAKLNHTKIIAEVLRQYPHIVKG-----HKNIKL-KIM 364
            ....|:   ||:...:|.....:|| .:....|..:|.|.:..:..:.:|     |:..|: :.:
Zfish   435 PELQILMQELKEKPEAQKLLQTIKD-IDVLFKHKSLILETISDFTVLEQGLNAMDHETEKVTEFL 498

  Fly   365 PNTPAAPTE-KSAPATVKPPANQSSATTSPHKKLHVSFKADKSTPLITAQQKAA---SSQQKSGT 425
            .:...|..| :|...||....::.|...||..:|..:..  ||.|.::..::.|   |..:..|.
Zfish   499 QSCRRADGELESVVQTVDRVLSRDSGFASPLCQLMCANL--KSFPQLSPLKQTAGLVSDSECPGK 561

  Fly   426 SQTTGNQG----------------TGANPPANTAAA---------QKRRIDSKTMHALIAQGAEN 465
            ::.  .||                ||...|...:.:         .|.|:........:|.|.|.
Zfish   562 AEV--EQGGSAVDSEDEDDEDCSSTGRRKPVLVSYSCDWCRKTFDFKCRLIKHRKGCALAPGKEQ 624

  Fly   466 TTGPWLCLRCGVNGRPISIPSYRGFRRHLINTH------KETIDPALCEHCGWRSVNNRELHFHM 524
            .     |..|.     ::.|:.:...:|.:.||      |:..:...|:.|.....::..|.:|.
Zfish   625 R-----CCECS-----MAFPTLKSLHQHCVETHGGPPAKKKKTEHVACDICDKTFKHSSGLLYHK 679

  Fly   525 YMEH----------------QTKSL-----LYTFAE---CALCNQSYRTKGELEAHINEVHTDDN 565
            ..||                .|.||     |:|..:   |..|:.|:.....|..|..:.|.:..
Zfish   680 RTEHFEERPYACEECGAKFAATSSLKNHMRLHTGEKPFHCKHCDMSFSVAAALSYHTKKKHAEGK 744

  Fly   566 KQQCIYCNKVFEQELQLYRHMKSYHKEQALEDGIIDETDEEFLGSQDEEEEAEGDEEQEPEQTGK 630
            ...|.||:..|.|.::|.||::::                            .||:.....:.||
Zfish   745 MYCCQYCSASFAQSIELTRHVRTH----------------------------TGDKPYVCRECGK 781

  Fly   631 VRILSDISLPATSAITVQQAQQEQLQE-EDVEQVQQEVKFVGADGNEVELTDEQRKEILSQLNQQ 694
                   .....:.::|.......:.| .|.::.:  |.|...|    ||....:|....:|:|.
Zfish   782 -------GFKQANGLSVHLQNFHNITEPHDCQKCR--VSFSSLD----ELRQHIQKVHPKELHQC 833

  Fly   695 QAGATAGGVVMVLSEPEAEHVKQETDEKSLAGTEEEYDDSQIYSELGAADSVESAKKNIADESK- 758
                           ||.                     |:||:..||.:.    ..|:.|.:|
Zfish   834 ---------------PEC---------------------SKIYNSEGALEK----HMNVHDGNKP 858

  Fly   759 ----------ESIDNLEWAENLIAESE---EQSNKEPKS-------DKPRDDISEKLK-ELTGD- 801
                      :::..| |..|.....|   .|||:..|:       ||.....:..:| ::|..
Zfish   859 YSCKTCNKAYQTLSGL-WYHNRTVHPEISTSQSNRSLKALLQCERCDKSFTSHNSLIKHQITNHT 922

  Fly   802 ----W----------TEDENDDDVDDKPATAELASELAN----KDPEPTVHEEEDDIDLALQSLH 848
                |          :|.|....|......|..:..:.:    .:|:...|.....:.|...
Zfish   923 DVHVWKCVSCDCSLSSEQELQHHVCSVQTPALFSCMVCSLHFPSEPDFQQHFLSKHLQLVQD--- 984

  Fly   849 KGPEEATEEKASEESV---TSADDAVDAVPNIN-SQPE-KMDVDSEAADEK---ASKAEVQIKKE 905
               |..|:..||:..|   .:||.||:.|.|:: ||.| ...|....||::   |....|.:..|
Zfish   985 ---EAQTQSSASQTVVQCEAAADPAVEQVINLHQSQSESSQQVFVALADQQETPAGSGMVAVSME 1046

  Fly   906 AELENDQEEFIKEDS 920
             :|.|.....|.|.|
Zfish  1047 -DLLNGTVTLICEQS 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	28/121 (23%)
		BTB	31..127	CDD:197585	26/115 (23%)
		C2H2 Zn finger	540..568	CDD:275371	6/27 (22%)
		C2H2 Zn finger	569..586	CDD:275371	7/16 (44%)
zbtb40	XP_005172972.1	BTB	14..113	CDD:279045	24/104 (23%)
		BTB	25..113	CDD:197585	22/93 (24%)
		C2H2 Zn finger	626..647	CDD:275368	4/25 (16%)
		C2H2 Zn finger	662..683	CDD:275368	4/20 (20%)
		C2H2 Zn finger	691..711	CDD:275368	3/19 (16%)
		zf-H2C2_2	703..727	CDD:290200	7/23 (30%)
		C2H2 Zn finger	719..768	CDD:275368	14/48 (29%)
		zf-H2C2_2	760..785	CDD:290200	7/59 (12%)
		C2H2 Zn finger	776..797	CDD:275368	3/27 (11%)
		C2H2 Zn finger	833..853	CDD:275368	8/59 (14%)
		C2H2 Zn finger	861..882	CDD:275368	3/21 (14%)
		C2H2 Zn finger	900..917	CDD:275368	3/16 (19%)
		C2H2 Zn finger	929..947	CDD:275368	2/17 (12%)
		C2H2 Zn finger	957..973	CDD:275368	1/15 (7%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24394
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100