DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cp190 and zbtb7a

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	XP_005170586.1	Gene:	zbtb7a / 565670	ZFINID:	ZDB-GENE-050208-583	Length:	617	Species:	Danio rerio

Alignment Length:	686	Identity:	141/686 - (20%)
Similarity:	216/686 - (31%)	Gaps:	238/686 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 CDLTLQFRDNSQLKVHRLVLSACTDYFNVLEQTCEIVDDALIMPNEF-QADVVVPIVNFMYTGTL 93
            ||:.|..:: ::...||.||::|:.||:.|..:....|...:...:| :.:.:..:::|.||.||
Zfish    81 CDVLLVAQE-TEFPAHRSVLASCSTYFHNLFTSGPAADRQKVYELDFVRPEALAALLDFAYTATL 144

  Fly    94 EFELKMYGKLLRTAKEMNMT----VLLKLLE-------AHRRTMENVNRQQRPPSPK--GIRRRT 145
            .........:|..|..:.::    |...||:       |.....:|...::|..:.|  |||.|.
Zfish   145 TVSRNSVVDILSAAHVLEISPVQDVCTHLLDTKVLSPPAGNEQEDNEEEEERGKNGKEQGIRLRA 209

  Fly   146 ------------VGQPSSGLPQQRVLGPSPQSRNVATPI--AQRANTQRGSTGNTMSRTSGGSNR 196
                        .|...|          :|:.|::...:  :||....|              |.
Zfish   210 REYLEFFQRGAHWGSSCS----------TPELRDLPAHLHFSQRNGADR--------------NG 250

  Fly   197 SPYGDSSNVKQEPTSPFEQLRKGYNNNKRPAQTSLLSPPSKKPSLEEVKEFAEQ-QRMRKQIA-- 258
            .|.|.:     :..||..|               .||.|.:.|..|.|.|.::. .|.|:::|
Zfish   251 IPIGPA-----DYYSPLAQ---------------ALSQPPRDPEDENVDEESQDVARAREKVAEG 295

  Fly   259 -------AEYG-----DNDPEYDGGMLYDDVHAGDDDDDDMPPQPSTSKQQSPQGTQTQLEHGST 311
                   .:.|     ..||:.:     .:|....|.:.:..| .|...||.....:.:.|.|:|
Zfish   296 LMPFFAPTQNGHYYLHQADPKSE-----REVEVTGDREHNQGP-ASALLQQMMDSLERKRERGTT 354

  Fly   312 TIILKQDSP-SQTPTIIVKDSSNAKLNHTKIIAEVLRQYPHIVKGHKNIKLKIMPNTPAAPTEKS 375
            ....:.|.| ...|.:                               ...||.....|..||
Zfish   355 GGGGEDDGPEGDEPDV-------------------------------EFYLKYFSAQPEGPT--- 385

  Fly   376 APATVKPPANQSSATTSPHKKLHVSFKADKSTPLITAQQKAASSQQKSGTSQTTGNQGTGANPPA 440
                        ||..||           ...||...:.....:|...|     ||.|   ....
Zfish   386 ------------SAPISP-----------SLAPLWPVRGNGGGNQATGG-----GNSG---ERKM 419

  Fly   441 NTAAAQKRRIDSKTMHALIAQGAENTTGPWLCLRCGVNGRPISIPSYRGFRRHLINTHKETIDPA 505
            .:.|.||..|.||     :.|||               |:   :|      || |.||... .|.
Zfish   420 RSKAFQKCPICSK-----VIQGA---------------GK---LP------RH-IRTHTGE-KPY 453

  Fly   506 LCEHCGWRSVNNRELHFHMYMEHQTKSLLYTFAECALCNQSYRTKGELEAHINEVHTDDNKQQCI 570
            .|..|..|.....:|..||......|..|     |..|..::....:|:.|: .|||.....||.
Zfish   454 ECAICKVRFTRQDKLKVHMRKHTGEKPYL-----CTQCGAAFAHNYDLKNHM-RVHTGLRPYQCS 512

  Fly   571 YCNKVFEQELQLYRHMKS--------------YHKEQALEDGIID----ETD------------- 604
            .|.|.|.:...|:||:|.              ..::..|.:|.::    |||
Zfish   513 SCFKTFVRSDHLHRHLKKDGCNGIPSRRGRKPRIRDSELLEGSLELHGPETDIERGRRHPDRGTI 577

  Fly   605 ---------EEFLGSQDEEEEAEGDEEQEPEQTGKV 631
                     ||..||......|:| |..|...:|:|
Zfish   578 SHHQSPSVMEENHGSHTHSPVADG-EGSEVLTSGQV 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	23/103 (22%)
		BTB	31..127	CDD:197585	23/107 (21%)
		C2H2 Zn finger	540..568	CDD:275371	7/27 (26%)
		C2H2 Zn finger	569..586	CDD:275371	6/16 (38%)
zbtb7a	XP_005170586.1	BTB	71..175	CDD:279045	22/94 (23%)
		BTB	82..177	CDD:197585	22/95 (23%)
		COG5048	425..>488	CDD:227381	26/98 (27%)
		C2H2 Zn finger	427..447	CDD:275368	11/49 (22%)
		zf-H2C2_2	442..464	CDD:290200	9/23 (39%)
		C2H2 Zn finger	455..475	CDD:275368	6/19 (32%)
		zf-H2C2_2	468..492	CDD:290200	7/28 (25%)
		C2H2 Zn finger	483..503	CDD:275368	4/20 (20%)
		zf-H2C2_2	495..520	CDD:290200	10/25 (40%)
		C2H2 Zn finger	511..529	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24394
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100