DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cp190 and zbtb11

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_997815.2	Gene:	zbtb11 / 555217	ZFINID:	ZDB-GENE-030131-5055	Length:	1146	Species:	Danio rerio

Alignment Length:	1101	Identity:	209/1101 - (18%)
Similarity:	363/1101 - (32%)	Gaps:	328/1101 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VKVDNWGVF--FLQK----------LQNFFNKTDYCDLTLQFRDNSQLKVHRLVLSACTDYFNVL 59
            |.||:.|:.  ||||          ||...|  ::||:|| ..:..:.:.|:.||::|:|||..|
Zfish   176 VFVDSKGIVKQFLQKHGQTMLDKLNLQRMNN--EFCDITL-IIEGEEYRAHKAVLASCSDYFYEL 237

  Fly    60 --EQTCEIVDDALIMPNEFQADVVVPIVNFMYTGTLEFELKMYGKLLRTAKEMNMTVLLKLLEA- 121
              |:......:|::..:.|.....:|:::|.||..|.|...:..::...|:.:.|..:|::.|:
Zfish   238 FVEKGAVSSHEAVVDLSGFSKASFLPLLDFAYTSNLTFNFCVMAEVATLARHLLMAEVLQICESV 302

  Fly   122 HRRTME----------------NVNRQQRPPSPKGIRRRTVGQPSSGLPQ--------------- 155
            |::..|                |.....:|.:|.......|...|.|..:
Zfish   303 HKKVEEQKLMVYQRGDIHTVLPNQPASTQPITPTAAETYVVTMQSDGTAEAGQSLAVITSEIGTA 367

  Fly   156 ---------------QRVLGPSPQSRNVATPIAQRANTQRGSTGNTMSRTS----GGSNRS---- 197
                           ..|:..|.|:.: |..:|..|::.:...|.||:..:    .||..|
Zfish   368 ESLALLAGATVDGETMTVVTHSGQAGS-AESLAMVAHSGQAEEGETMTLVTHSGQAGSGESLAVV 431

  Fly   198 ---------PYGDSSNVKQEPTSPF----------------------------EQLRKGYNNNK- 224
                     ..||:..|:...|..|                            .|..|..:..:
Zfish   432 QACWSVEEPQVGDTPVVQSMQTGAFLISVDPGKTGASEIVHLAAAAPPAVQDEPQASKPIHQTEP 496

  Fly   225 -----------------RPAQTSLLSPPSKKPSLEEVKEFAEQQRMRKQIAAEYGDNDPEY---- 268
                             ||.:.....||...||.:|..|....:...|| ..|..|.:..|
Zfish   497 PAAAPQPSPAPLKRRPGRPPKVKQQEPPPPLPSEDEPMEMEGVEDDEKQ-EDECIDPNKRYLRKR 560

  Fly   269 ---DGGMLYDDVHAGDDDDDD----MPP------------QPSTSKQQSPQG--TQTQLEHGSTT 312
               :||  |..:|.|.:.:::    .||            :|..|.:::|:.  ::|.||.....
Zfish   561 SVREGG--YVRLHMGLETEEEEKITSPPAKIPQKGLAKRGRPVQSAKKNPETEFSETNLEAAPNA 623

  Fly   313 IILKQDSPSQTPTIIVKDSSNAKLNHTKIIAEVLRQYPHIVKGHKNIKLKIMPNTPAAPTEKSAP 377
            |:.....|.                            |.||:..:.::...:|..|....|....
Zfish   624 IVTSAKEPE----------------------------PVIVEQPETVEEGALPGDPEGAVEGEHA 660

  Fly   378 ATVKPPANQSSATTSPHKKLHVSFKADKSTPLITAQQKAAS--------SQQKSGTSQTTGNQGT 434
            ........|...|...|...|...:..|.:......|.|||        ..|||..:..|
Zfish   661 CNECGMVFQRRYTLIMHALKHEKARIFKCSICNKEFQYAASLRAHLARHKHQKSQRASLT----- 720

  Fly   435 GANPPANTAAAQKRRIDSKTMHALIAQGAEN-----TTGPWLCLRCGVNGRPISIPSYRGFRRHL 494
                              :.|....:||:::     |...::|..||.     ::|.....|.|:
Zfish   721 ------------------RAMATEDSQGSDDQARFRTRREFVCDICGK-----TMPKLYSLRIHM 762

  Fly   495 INTHKETIDPALCEHCGWRSVNNRELHFHMYMEHQTKSLLYTFAECALCNQSYRTKGELEAHINE 559
            :|  ...:.|..|:.||........|..|..:....|..     .|.:|.:|:.||..||.| ..
Zfish   763 LN--HTGVRPHSCKVCGKSFATKHSLKMHRALHDSLKRF-----HCTVCEKSFVTKRSLEEH-TS 819

  Fly   560 VHTDDNKQQCIYCNKVFEQELQLYRHMKSYHKEQALEDGIIDETDEEFLGSQDEEEEAEGDEEQE 624
            :||.::|..|..|...|.:...|.:|:|.:..:..:........|:.|..::|.::........:
Zfish   820 IHTGESKYLCTTCGASFHRASGLSKHLKKHQPKPEVRSFHCSHCDKSFFEAKDLQQHMNKHLGLK 884

  Fly   625 PEQ---TGKV---------RILS-DISLPATSAITVQQAQQEQLQEEDVEQVQQEVKFVGADGNE 676
            |.|   .||.         .:.| .::.|....:..::..::.|....|::.....|  |.....
Zfish   885 PFQCQVCGKCYSWKKDWYSHVKSHSVAEPFRCNVCGKEFFEKALFRRHVKKATHGKK--GRVKQN 947

  Fly   677 VELTDE-------QRKEILSQLNQQQA----GATAGGVVMVLSEPEAEHVKQETDEKSLAG--TE 728
            :|...|       |.:|....:|..|.    .....||....:.....||:..|.|:....  .:
Zfish   948 LERECEHCGRKFTQLREYRRHMNNHQGVKPFECLTCGVAWADARSLKRHVRTHTGERPYVCPLCQ 1012

  Fly   729 EEYDDSQIYSELGAADSVESAKKNIADESKESIDNLEWAENLIAESEEQSNKEPKSDKPRDDISE 793
            |.:.|::            :.:|:|   :|...|.|                      |...:.|
Zfish  1013 EAHIDAR------------TLRKHI---TKFHGDQL----------------------PGKIMLE 1040

  Fly   794 K-LKELTGDWTEDENDDDVDDKPATAELASELAN--KDPEPTVHEE-------EDDIDLALQSLH 848
            | ..:.....|:.|:        |.:.|:|||..  :.|:|...||       |:.:: |:|:::
Zfish  1041 KDTLQFHNQGTQVEH--------AVSILSSELPPELQPPQPPATEEIETVLITEETVE-AVQAMN 1096

  Fly   849 KGPEEATEEKASEESVTSADDAVDAVPNINSQPEKMDVDSEAADEKASKAEVQIKKEAELE 909
            .|....|   .|::|:....:.|.|        ::..|..|.|.|.....||::...||:|
Zfish  1097 DGAAVTT---LSDQSIMQVVNYVLA--------QQAAVKVEEAPEIIQTMEVEVAHVAEVE 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	28/104 (27%)
		BTB	31..127	CDD:197585	25/98 (26%)
		C2H2 Zn finger	540..568	CDD:275371	11/27 (41%)
		C2H2 Zn finger	569..586	CDD:275371	4/16 (25%)
zbtb11	NP_997815.2	BTB	199..300	CDD:279045	27/103 (26%)
		BTB	210..301	CDD:197585	23/91 (25%)
		C2H2 Zn finger	661..681	CDD:275368	3/19 (16%)
		C2H2 Zn finger	689..709	CDD:275368	4/19 (21%)
		COG5048	<743..905	CDD:227381	38/174 (22%)
		C2H2 Zn finger	745..765	CDD:275368	7/26 (27%)
		zf-H2C2_2	757..782	CDD:290200	7/26 (27%)
		C2H2 Zn finger	773..793	CDD:275368	5/19 (26%)
		C2H2 Zn finger	801..821	CDD:275368	8/20 (40%)
		zf-H2C2_2	813..838	CDD:290200	9/25 (36%)
		C2H2 Zn finger	829..849	CDD:275368	6/19 (32%)
		C2H2 Zn finger	860..880	CDD:275368	3/19 (16%)
		zf-H2C2_2	872..896	CDD:290200	5/23 (22%)
		C2H2 Zn finger	888..908	CDD:275368	2/19 (11%)
		C2H2 Zn finger	916..938	CDD:275368	2/21 (10%)
		C2H2 Zn finger	952..972	CDD:275368	4/19 (21%)
		C2H2 Zn finger	980..1000	CDD:275368	4/19 (21%)
		zf-H2C2_2	992..1014	CDD:290200	4/21 (19%)
		C2H2 Zn finger	1008..1029	CDD:275368	5/35 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	108	1.000	Inparanoid score	I4893
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24394
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.150