DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cp190 and Zbtb3

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001102632.1	Gene:	Zbtb3 / 499313	RGDID:	1561140	Length:	517	Species:	Rattus norvegicus

Alignment Length:	654	Identity:	133/654 - (20%)
Similarity:	210/654 - (32%)	Gaps:	211/654 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LQKLQNFFNKTDYCDLTLQFRDNSQLKVHRLVLSACTDYFNVLEQTCEI-VDDALIMPNEFQADV 80
            ||.|:...::...||.|:.. .:.|...||.||::|:.:|.:..:..|: ..|.:.:.||.   |
  Rat    11 LQSLREQRSQGFLCDCTVMV-GSIQFLAHRAVLASCSPFFQLFYKERELDKRDLVCIHNEI---V 71

  Fly    81 VVP----IVNFMYTGTLEFELKMYG-----KLLRTAKEMNMTVLLKLLEAHRRTMENVNRQQRPP 136
            ..|    :::|||.|    :|.:.|     .:|..|..::|..::|:.
  Rat    72 TAPAFGLLLDFMYAG----QLALRGDTPLEDVLAAASYLHMNDIVKVC----------------- 115

  Fly   137 SPKGIRRRTVGQPSSGLPQQRVLGPSPQSRNVATPIAQRANTQRGSTGNTMSRTSGGSNRSPYGD 201
                              :||:     |:|.:|.                             .|
  Rat   116 ------------------KQRL-----QARALAE-----------------------------AD 128

  Fly   202 SSNVKQEPTSPFE-QLRKGYNNNKRPAQTSLLSPPSKKPSLEEVKEFAEQQRMRKQIAAEYGDND 265
            |:. |:|.|:|.. :...|.:...:|...|:  .||.:.|.||.|..|      ..:...:..:.
  Rat   129 STK-KEEETNPASLEFLSGSSRGPQPLLASV--EPSVRWSKEEWKGPA------TPLPIAHPADG 184

  Fly   266 PEYDGG-------MLYDDVHAGDDDDDDMPPQP----STSKQQSPQGTQTQLEHGSTTIILKQDS 319
            |...||       |..|..|.      ..||.|    |.|.......|:|              :
  Rat   185 PPVSGGADTTQPSMEVDSSHL------RAPPPPVADVSVSLASPSSSTET--------------T 229

  Fly   320 P-----SQTPTIIVKDSSNAKLNHTKIIAEVLRQYPHIVKGHKNIKLKIMPNTPAAPTE---KSA 376
            |     |..||:.|:     .|....::.|.||              .:.|.....|.:   ..|
  Rat   230 PVNYFSSGLPTVSVE-----PLTPLDVVPESLR--------------VVEPRDTGGPLQGFYPPA 275

  Fly   377 PATVKPPANQSSATTSPHKKLHVSFK------ADKSTPLITAQQKAASSQQKSGTSQTTG--NQG 433
            ||....||...|..|:|.:...|..|      :|:.|.|...|.:.:.....||.:...|  :|.
  Rat   276 PAPPPAPAPVLSQATAPVEAELVQVKVEAIVISDEETDLSEEQPQGSEGLFPSGGAMYGGQPSQA 340

  Fly   434 TGANPPANTAAAQKRRIDSKTMHALIAQGAENTTGPWLCLRCGVNGRPISIPSYRGFRRHLINTH 498
            .....|..|...:....|    |.|..:       |.|....        :|....:.|.|: |.
  Rat   341 EAFEEPGATGLEEVGPSD----HFLPPE-------PHLPYHL--------LPGPGQYHRGLV-TS 385

  Fly   499 KETIDPALCEHCGWRSVNNRELHFHMYMEHQTKSLLYTFAE-------CALCNQSYRTKGELEAH 556
            .....||              ||..:|...:.::...:|..       |..|.:::.....|..|
  Rat   386 PLPAPPA--------------LHEPLYPPSEYEAAQGSFGSFTEDVPTCKTCGKTFSCSYTLRRH 436

  Fly   557 INEVHTDDNKQQCIYCNKVFEQELQLYRHMKSYHKEQALEDGIIDETDEEFL------GSQDEEE 615
            .. |||.:...:|.||.:.:.|...||||::..|.|...:....|......|      |||..|.
  Rat   437 AT-VHTRERPYECRYCLRSYTQSGDLYRHIRKAHNEDLAKRSKPDPEASTILGVQPLSGSQTTER 500

  Fly   616 EAEG 619
            .:.|
  Rat   501 HSGG 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	27/111 (24%)
		BTB	31..127	CDD:197585	25/105 (24%)
		C2H2 Zn finger	540..568	CDD:275371	7/27 (26%)
		C2H2 Zn finger	569..586	CDD:275371	7/16 (44%)
Zbtb3	NP_001102632.1	BTB	14..120	CDD:279045	29/153 (19%)
		BTB	25..119	CDD:197585	26/136 (19%)
		COG5048	<418..493	CDD:227381	19/75 (25%)
		C2H2 Zn finger	420..440	CDD:275368	4/20 (20%)
		zf-H2C2_2	433..457	CDD:290200	8/24 (33%)
		C2H2 Zn finger	448..466	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24394
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100