DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cp190 and hic1

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001002314.1	Gene:	hic1 / 436585	ZFINID:	ZDB-GENE-040713-2	Length:	737	Species:	Danio rerio

Alignment Length:	828	Identity:	157/828 - (18%)
Similarity:	271/828 - (32%)	Gaps:	284/828 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SVKVDNWGVFFLQKLQNFFNKTDYCDLTLQFRDNSQLKVHRLVLSACTDYFN--VLEQTCEIVDD 68
            :::|.:.....|.:|.....|...||:.:..: |:..:.|:.:|:|.:.|..  |:......:|.
Zfish     4 AMEVPSHARHLLLQLNTQRTKGFLCDVIIVVQ-NALFRAHKNILAASSLYLKSLVVHDNLINLDH 67

  Fly    69 ALIMPNEFQADVVVPIVNFMYTGTL---------EFELKMYGKLLRTAKEMNM----TVLLKLLE 120
            .::.|..|:.     |::::|||.|         |..:   |.:|..|..:.:    |:..|.|:
Zfish    68 EMVSPGVFRV-----ILDYIYTGRLSECDPTSPNEPNI---GAVLAAASYLQLLDLVTLCKKKLK 124

  Fly   121 AHRR--------------TMENVNRQQRPPSPKGI----------RRRTVGQ-PSSGLPQQR--- 157
            .:|:              ::..|.....|.|...|          |..|:.. ||..||...
Zfish   125 KNRKYHLSHNPTFLSYKLSLSGVGGGPFPISTPVIHPCHTVVTTPRPTTLEDLPSIPLPPHAGEI 189

  Fly   158 -----VLGP----------SPQSRNVATPIAQRANTQRG-----STGNTMSRTSGGS-------- 194
                 :.||          ||||.....|..:..::..|     .:.|:.|:.|.|:
Zfish   190 YAPAPIKGPPPYPPTKASLSPQSSLCLPPNERNCSSVYGLDLSKKSPNSQSQLSSGNPHLISSLH 254

  Fly   195 -NRSPYGDSSNVKQEPTSPFEQLRK---GYNN----------------------NKRPAQTSLLS 233
             :..|.|:.........||.:..||   |::.                      ::...|.....
Zfish   255 PDEEPEGELDQSTSPMLSPNDGSRKMDTGHHMGSLTPHPFPLPNHPLAPNLPHLHRSQGQEQYPC 319

  Fly   234 PPSKKPSLEEVKEFAEQQRMRKQIAAEYGDNDPEYDGGMLYDDVHAGDDDDDDMPPQPSTSKQQS 298
            |||.:|    :::..:|:|....| ..:..|:|.          :..|:|:||         ::.
Zfish   320 PPSPEP----IEDTRDQRRDASNI-YRWVKNEPS----------NPEDEDEDD---------EED 360

  Fly   299 PQGTQTQLEHGSTTIILKQDSPSQTPTIIVKDSSNAKLNHTKIIAEVL----------------- 346
            ..|...:           ||          |:..:..:||.|...|.|
Zfish   361 DSGGMGE-----------QD----------KERHHQHMNHHKSNEEKLNTNERGYDRGTCDDGED 404

  Fly   347 --------------RQYPHIVKGHKNIKLKIMPNTPAA---------PTEKSAPATVKPPANQSS 388
                          |..|.:..|..:     ||..|.:         |.:|..|         ||
Zfish   405 ENGTGSEETGSSEGRPSPPVPGGRYH-----MPYEPESFGDNLYVCIPCDKGFP---------SS 455

  Fly   389 ATTSPHKKLHVSFKADKSTPLITAQQKAASSQQKSGTSQTTGNQGTGANPPANTAAAQKRRIDSK 453
            ...:.|.:.|...:.:..:.:.::..  ::|:..:..:.|:.|..:|.:.|.:         |.|
Zfish   456 EQLNAHVETHTEEELNNGSEMDSSNN--SNSKPTTVRAPTSLNSSSGLHSPYH---------DGK 509

  Fly   454 TMHALIAQGAENTTGPWLCLRCGVNGRPISIPSYRG---FRRHLINTHKETIDPALCEHCG---- 511
            ....|.:.|......|:.|..|.        .||:.   .|:| ..||..| .|..|..||
Zfish   510 LAQNLHSIGLGEIIRPYRCSSCD--------KSYKDPATLRQH-EKTHWLT-RPYPCSICGKKFT 564

  Fly   512 WRSVNNRELHFHMYMEHQTKSLLYTFAECALCNQSYRTKGELEAHINEVHTDDNKQQCIYCNKVF 576
            .|....|.:..|:.::        .|| |..|...:..:..|..|: .:|:.:...:|..|...|
Zfish   565 QRGTMTRHMRSHLGLK--------PFA-CDACGMRFTRQYRLTEHM-RIHSGEKPYECQVCGGKF 619

  Fly   577 EQELQLYRHMKSYHKEQA-------------LEDGI--IDETDEEFLGSQDEE------------ 614
            .|:..|..|||.:....|             ..:||  :.:...|.||.:.|:
Zfish   620 AQQRNLISHMKMHSSGAAGGGLTPDGKLKIDFSEGIYPLSKYTAEHLGLKQEKTSDLLAASQHLL 684

  Fly   615 EEAEGDEEQEP------EQTG---KVRILSDISLPATSAITVQQAQQE 653
            .:|:..|...|      :|.|   |:.||:. |||.||    ||...|
Zfish   685 ADAKAMESLYPLSKLAVDQLGLAHKMDILNS-SLPPTS----QQLSAE 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	25/116 (22%)
		BTB	31..127	CDD:197585	23/124 (19%)
		C2H2 Zn finger	540..568	CDD:275371	5/27 (19%)
		C2H2 Zn finger	569..586	CDD:275371	5/16 (31%)
hic1	NP_001002314.1	BTB	18..119	CDD:279045	23/109 (21%)
		BTB	29..119	CDD:197585	20/98 (20%)
		C2H2 Zn finger	445..465	CDD:275368	6/28 (21%)
		C2H2 Zn finger	528..548	CDD:275368	6/28 (21%)
		zf-H2C2_2	541..565	CDD:290200	9/25 (36%)
		zf-C2H2	554..576	CDD:278523	5/21 (24%)
		C2H2 Zn finger	556..576	CDD:275368	5/19 (26%)
		zf-H2C2_2	569..593	CDD:290200	6/32 (19%)
		C2H2 Zn finger	584..604	CDD:275368	4/20 (20%)
		zf-H2C2_2	597..621	CDD:290200	6/24 (25%)
		C2H2 Zn finger	612..632	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24394
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100