DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cp190 and bcl6aa

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	XP_021332488.1	Gene:	bcl6aa / 393707	ZFINID:	ZDB-GENE-040426-1696	Length:	748	Species:	Danio rerio

Alignment Length:	737	Identity:	150/737 - (20%)
Similarity:	241/737 - (32%)	Gaps:	228/737 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DLTLQFRDNSQLKVHRLVLSACTDYFNVL---EQTCEIVDDALIMPNEFQADVVVPIVNFMYTGT 92
            |:|: ..:..|.:.|:.||.||:..|..:   ...|.:  :|:.:..:...:....::.||||..
Zfish    77 DVTI-LVNRQQFRAHKTVLMACSGLFYSIFTDSHKCNL--NAISLDPKVDPEGFAILLEFMYTSR 138

  Fly    93 LEFELKMYGKLLRTAKEMNM---------------------------TVLLKLLEAH----RRTM 126
            |..:..:...::.||..:.|                           :.||...:.|    ...|
Zfish   139 LALKESLIMAIMNTAIYLQMDHVVDTCHRFIKSSDSSIKLPREDFLVSPLLLPQDIHSYRPHEVM 203

  Fly   127 ENVNRQQ---RPPSPKGI----------RRRTVGQ-PSSGLP----------------------Q 155
            :||:.:.   |...|.|:          .....|| |..|.|                      .
Zfish   204 DNVSGRSATFRDGRPYGVCMFNGVNAPNNSYLYGQFPMQGFPFPLCKLTDTKNTFSDFSKGGIIH 268

  Fly   156 QRVLGPSPQSRNVATPIAQRANTQRGS-----TGNTMSRTSG-----------------GSNRSP 198
            .:...||..:..|.....:.|.:  ||     ||:..||..|                 |.:...
Zfish   269 HKHCSPSDGNNPVLNDFTRSATS--GSSAVCHTGSYSSRELGRDEDMKRETLEGVVHSIGMSSRK 331

  Fly   199 YG--------------DSSNVKQEPTSPFEQLRKGYNNNKRPAQTSLLSP---------PSKKPS 240
            :|              :.|::.:|..| .:....|.::|.|  :|.:.||         |:....
Zfish   332 HGFISLAQEQQRESGKEQSSLAEEHLS-HQHYSMGISSNGR--KTLMSSPQSPLKSDCQPNSPTE 393

  Fly   241 LEEVKEFAEQQRMRKQIAAEYGDNDPEYDGGMLYDDV--HAGDDDDDDMPPQPSTSKQQSPQGTQ 303
            ....|..|..|.:  |.....|.:||:......|..:  :....:::..||.|.....|.| |..
Zfish   394 SSSSKNAALAQAL--QPPTSQGTSDPKARNWKKYKFIVLNQSSKEEETNPPDPGMHSPQRP-GLS 455

  Fly   304 TQLEHGS--------TTIILKQ--DSP----SQTPTII----------VKDSSNAKLNHTKIIAE 344
            ..|.|..        ||.|.:|  |.|    |:...||          :...|:..:||.| .:.
Zfish   456 AFLHHVDSEHPDSKVTTKISEQGEDFPAPQASRLNNIINRSLEGSQRNIDSHSSLYMNHLK-CSS 519

  Fly   345 VLRQYPHIVKGHKNIKLKIMPNTPAAPTEKSAPATVKPPANQSSATTSPHKKLHVSFKADKSTPL 409
            ...|.|.    |.:    :.|||.|                  |.......::|..: :|.|...
Zfish   520 CGSQSPQ----HSD----VCPNTSA------------------SRLAEEMSEMHSEY-SDSSCEN 557

  Fly   410 IT-----AQQKAASSQQ-KSGTSQTTGNQGTGANPPANTAAAQKRRIDS-KTMHALIAQGAENTT 467
            .|     ...|.|..:. |..|.|...::....: ....|...|..:.| ||:|          |
Zfish   558 GTYFCNECDSKFAEEEALKRHTLQVHSDKPYKCD-RCQAAFRYKGNLASHKTVH----------T 611

  Fly   468 G--PWLCLRCGVN-GRPISIPSYRGFRRHLINTHKETIDPALCEHCGWRSVNNRELHFHMYMEHQ 529
            |  |:.|..||.. .||.::.::.  |.|  :..|    |..||.||.|.|....|..|:
Zfish   612 GEKPYRCNICGAQFNRPANLKTHT--RIH--SGEK----PYKCETCGARFVQVAHLRAHV----- 663

  Fly   530 TKSLLYTFAE---CALCNQSYRTKGELEAHINEVHTDDNKQQCIYCNKVFEQELQLYRHMKSYHK 591
               |::|..:   |.:|...:|....|::|: .:||.:....|..||..|..:.||..|::..|
Zfish   664 ---LIHTGEKPYPCEICGTRFRHLQTLKSHL-RIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKH- 723

  Fly   592 EQALEDGIIDETDEEFLGSQDE 613
                  |.|..|..::..|..|
Zfish   724 ------GAITNTKIQYRMSSTE 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	21/120 (18%)
		BTB	31..127	CDD:197585	22/129 (17%)
		C2H2 Zn finger	540..568	CDD:275371	7/27 (26%)
		C2H2 Zn finger	569..586	CDD:275371	6/16 (38%)
bcl6aa	XP_021332488.1	BTB	66..172	CDD:306997	19/97 (20%)
		DMP1	<284..558	CDD:311295	60/309 (19%)
		C2H2 Zn finger	562..583	CDD:275368	5/20 (25%)
		C2H2 Zn finger	590..610	CDD:275368	5/20 (25%)
		zf-H2C2_2	602..627	CDD:316026	10/34 (29%)
		C2H2 Zn finger	618..638	CDD:275368	6/21 (29%)
		zf-H2C2_2	630..655	CDD:316026	9/32 (28%)
		C2H2 Zn finger	646..666	CDD:275368	9/27 (33%)
		zf-H2C2_2	658..683	CDD:316026	6/32 (19%)
		C2H2 Zn finger	674..694	CDD:275368	5/20 (25%)
		zf-H2C2_2	687..711	CDD:316026	8/24 (33%)
		C2H2 Zn finger	702..720	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24394
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100