DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cp190 and Zbtb42

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001093930.1	Gene:	Zbtb42 / 382639	MGIID:	3644133	Length:	420	Species:	Mus musculus

Alignment Length:	618	Identity:	111/618 - (17%)
Similarity:	174/618 - (28%)	Gaps:	253/618 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GVFFLQKLQNFFNKTDYCDLTLQFRDNSQLKVHRLVLSACTDYFNVL--EQTCEIVDDALIMPNE 75
            ||..|.:|:........||.|:...| ::...||.||:||:.||::.  :|.....|..     .
Mouse     7 GVRLLGRLRQQRELGFLCDCTVLVGD-ARFPAHRAVLAACSVYFHLFYRDQPASSRDTV-----R 65

  Fly    76 FQADVV-VP----IVNFMYTGTLEFELKMYGKLLRTAKEMNMTVLLKLLEAHRRTMENVNRQQRP 135
            ...|:| ||    :::|||.|.|:........:|..|..::|..::|:.:...|        ::.
Mouse    66 LNGDIVTVPAFSRLLDFMYEGRLDLHNLPVEDVLAAASYLHMYDIVKVCKGRLR--------KKD 122

  Fly   136 PSPKGIRRRTVGQPSSGLPQQRVLGPSPQSRNVATPIAQRANTQRGSTGNTMSRTSGGSNRSPYG 200
            |.   :..||:|....|.|...:...||.....|
Mouse   123 PD---LETRTLGTELPGQPPHPLPSWSPAFCQAA------------------------------- 153

  Fly   201 DSSNVKQEPTSPFEQLRKGYNNNKRPAQTSLLSPPSKKPSLEEVKEFAEQQRMRKQIAAEYGDND 265
                                             |.:|.|||
Mouse   154 ---------------------------------PKAKHPSL------------------------ 161

  Fly   266 PEYDGGMLYDDVHAGDDDDDDMPPQPSTSKQQSPQGTQTQLEHGSTTIILKQDSPSQTPTIIVKD 330
                      .|.|........||....::|.|
Mouse   162 ----------GVKATHPLPTFGPPSWQVAEQSS-------------------------------- 184

  Fly   331 SSNAKLNHTKIIAEVLRQYPHIVKGHKNIKLKIMPNTPAAPTEKSAPATVKPPANQSSATTSPHK 395
                                    |..::.||..|.          |..|.||....::..|..:
Mouse   185 ------------------------GALDLSLKPSPR----------PEQVHPPCRLQTSLCSSVQ 215

  Fly   396 KLHVSFKADKSTPLITAQQKAASSQQKSGTSQTTGNQGTGANPPANTAAAQKRRIDSKTMHALIA 460
            ::        :.||:.|:|.:.|.|..|.......:.     ||...:|||...:|.:.:|
Mouse   216 QV--------AQPLVKAEQDSFSEQDSSSPQSADRSP-----PPVCASAAQGLAVDLEPLH---- 263

  Fly   461 QGAENTTGPWLCLRCGVNGRPISIPSYRGFRRHLINTHKETIDPALCEHCGWRSVNNRELHFHMY 525
              .|.|....|    |:...|:......|..|||      .|.|..|:.  :.|.:..:||...:
Mouse   264 --IEGTGSQQL----GLPAEPVLDSEELGPSRHL------CICPLCCKL--FPSTHALQLHLSAH 314

  Fly   526 MEH---------------------QTKSLLYTFAE------------CALCNQSYRTKGELEAHI 557
            ...                     :|.|..||...            |..|.:|::....|..|.
Mouse   315 FRERDSVRARLSPEGSVPTCPLCSKTFSCTYTLKRHERTHSGEKPYTCVQCGKSFQYSHNLSRHA 379

  Fly   558 NEVHTDDNKQQCIYCNKVFEQELQLYRHMKSYH 590
             .|||.:....|.:|.:.|.|...||||::.:|
Mouse   380 -VVHTREKPHACRWCERRFTQSGDLYRHVRKFH 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	28/108 (26%)
		BTB	31..127	CDD:197585	27/102 (26%)
		C2H2 Zn finger	540..568	CDD:275371	8/27 (30%)
		C2H2 Zn finger	569..586	CDD:275371	7/16 (44%)
Zbtb42	NP_001093930.1	BTB	14..114	CDD:279045	28/105 (27%)
		BTB	25..121	CDD:197585	27/109 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..204		26/240 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..247		6/29 (21%)
		C2H2 Zn finger	294..314	CDD:275368	5/21 (24%)
		COG5048	334..>388	CDD:227381	12/54 (22%)
		C2H2 Zn finger	334..354	CDD:275368	4/19 (21%)
		zf-H2C2_2	347..369	CDD:290200	2/21 (10%)
		C2H2 Zn finger	362..382	CDD:275368	5/20 (25%)
		C2H2 Zn finger	390..408	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24394
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100