DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cp190 and HIC1

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001091672.1	Gene:	HIC1 / 3090	HGNCID:	4909	Length:	733	Species:	Homo sapiens

Alignment Length:	831	Identity:	164/831 - (19%)
Similarity:	251/831 - (30%)	Gaps:	293/831 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LQKLQNFFNKTDYCDLTLQFRDNSQLKVHRLVLSACTDYFNVLEQTCEIVDDALIMPNEFQADVV 81
            |.:|.|...|...||:.:..: |:..:.|:.||:|.:.|...|     :|.|.|:   ....|:|
Human    34 LLQLNNQRTKGFLCDVIIVVQ-NALFRAHKNVLAASSAYLKSL-----VVHDNLL---NLDHDMV 89

  Fly    82 VP-----IVNFMYTGTL----------------EFELKMYGKLLRTAKEMNMTVLL----KLLEA 121
            .|     :::|:|||.|                |..|   |.:|..|..:.:..|:    |.|:.
Human    90 SPAVFRLVLDFIYTGRLADGAEAAAAAAVAPGAEPSL---GAVLAAASYLQIPDLVALCKKRLKR 151

  Fly   122 HRRTME---------NVNRQQRP---------------PSPKGIRRRTVGQPSSGLPQQRV---- 158
            |.:...         ......||               |||.|.......:|.|| |:..|
Human   152 HGKYCHLRGGGGGGGGYAPYGRPGRGLRAATPVIQACYPSPVGPPPPPAAEPPSG-PEAAVNTHC 215

  Fly   159 -----LGPSP-----QSRNVATPIAQRANTQRGSTGNTM-SRTSGGSNRSPYGDS------SNVK 206
                 .||.|     .|....:|:.....:::...|:.. .|........|..||      :..|
Human   216 AELYASGPGPAAALCASERRCSPLCGLDLSKKSPPGSAAPERPLAERELPPRPDSPPSAGPAAYK 280

  Fly   207 QEPTS-------PFEQLRK---------------GYNNNKRPAQTSLLSPPSK-KPSLEEVKEFA 248
            :.|.:       ||::|.:               |.....||...|||....| :|.|....:..
Human   281 EPPLALPSLPPLPFQKLEEAAPPSDPFRGGSGSPGPEPPGRPDGPSLLYRWMKHEPGLGSYGDEL 345

  Fly   249 EQQRMRKQIAAEYGDND---------------PEYDGGMLYDDVHAGDDDDD--DMPPQPSTSKQ 296
            .::|.......|....|               |.|.|.:  |...||.|.||  ....:..:|:.
Human   346 GRERGSPSERCEERGGDAAVSPGGPPLGLAPPPRYPGSL--DGPGAGGDGDDYKSSSEETGSSED 408

  Fly   297 QSPQGTQTQLEHGSTTIILKQDSPSQTPTIIVKDSSNAKLNHTKIIAEVLRQY--PHIVKGH--- 356
            .||.|                                   .|       |..|  ||:..|.
Human   409 PSPPG-----------------------------------GH-------LEGYPCPHLAYGEPES 431

  Fly   357 --KNIKLKIMPNTPAAPTEKSAPATVKPPANQSSATTSPHKKLHVSFKADKSTPLITAQQKAASS 419
              .|:.:.|       |..|..|         ||...:.|.:.||             :::.|..
Human   432 FGDNLYVCI-------PCGKGFP---------SSEQLNAHVEAHV-------------EEEEALY 467

  Fly   420 QQKSGTSQTTGNQGTGANPPANTAAAQKRRIDSKTMHALIAQGAENTTG----PWLCLRCGVNGR 480
            .:........|..|.|  ||......:             ..||....|    |:.|..|.
Human   468 GRAEAAEVAAGAAGLG--PPFGGGGDK-------------VAGAPGGLGELLRPYRCASCD---- 513

  Fly   481 PISIPSYRG---FRRHLINTHKETIDPALCEHCG----WRSVNNRELHFHMYMEHQTKSLLYTFA 538
                .||:.   .|:| ..||..| .|..|..||    .|....|.:..|:.::        .||
Human   514 ----KSYKDPATLRQH-EKTHWLT-RPYPCTICGKKFTQRGTMTRHMRSHLGLK--------PFA 564

  Fly   539 ECALCNQSYRTKGELEAHINEVHTDDNKQQCIYCNKVFEQELQLYRHMKSYHKEQAL-EDGIIDE 602
             |..|...:..:..|..|: .:|:.:...:|..|...|.|:..|..|||.:....|. ..|.:
Human   565 -CDACGMRFTRQYRLTEHM-RIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGAL-- 625

  Fly   603 TDEEFLGSQDEEEEAEGDEEQEPEQTGKVRILSDISLPATSAITVQQAQQEQLQEED-------- 659
                         ...|.....|...||.::.....:.|.:.:|   |:|..|:::|
Human   626 -------------AGLGGLPGVPGPDGKGKLDFPEGVFAVARLT---AEQLSLKQQDKAAAAELL 674

  Fly   660 -------------VEQVQQEVKFVGADGNEVELTDEQRKEILSQLNQQQAG 697
                         :|.:....||..    |:.|:.::..|:|||.....||
Human   675 AQTTHFLHDPKVALESLYPLAKFTA----ELGLSPDKAAEVLSQGAHLAAG 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	31/126 (25%)
		BTB	31..127	CDD:197585	28/120 (23%)
		C2H2 Zn finger	540..568	CDD:275371	5/27 (19%)
		C2H2 Zn finger	569..586	CDD:275371	5/16 (31%)
HIC1	NP_001091672.1	BTB_POZ	26..155	CDD:365784	33/132 (25%)
		Mediates HDAC-dependent transcriptional repression	154..315		26/161 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..209		8/20 (40%)
		PHA03247	<223..325	CDD:223021	17/101 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	241..421		38/223 (17%)
		Interaction with CTBP1	241..247		0/5 (0%)
		COG5048	<501..613	CDD:227381	33/131 (25%)
		C2H2 Zn finger	509..529	CDD:275368	6/28 (21%)
		zf-C2H2	535..557	CDD:395048	5/21 (24%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..585	CDD:275368	4/20 (20%)
		zf-H2C2_2	577..602	CDD:404364	6/25 (24%)
		C2H2 Zn finger	593..613	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24394
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100