DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cp190 and zormin

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001261317.1	Gene:	zormin / 2769001	FlyBaseID:	FBgn0052311	Length:	3664	Species:	Drosophila melanogaster

Alignment Length:	1253	Identity:	249/1253 - (19%)
Similarity:	442/1253 - (35%)	Gaps:	320/1253 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 VLSACTDYFNVLEQTCEIVDDALIMPNEF--QADVVVPIVNFMYTGTLEFEL------------- 97
            |||.||::.::::|.    :..|....||  :|:..|.::.     .||.||
  Fly   417 VLSGCTEHLDLVDQR----EHWLHQSREFFAKAEHTVSVLE-----KLELELTSVKLPPHSPESY 472

  Fly    98 KMYGKLLRTAKEMNMTVLLKLLEAHRRTMENVNRQQRPPSPKGIRRRTVGQPSSGLPQQRVLGPS 162
            .|:.|:.|..:  |.|.  :.|......::.|.|.|  |..:|::|......:..:..|.:...|
  Fly   473 AMFSKVDRDVR--NFTE--EPLRLGYGILDEVGRTQ--PETQGVKRVLDELENRKVYIQGICANS 531

  Fly   163 PQSRNVATPIAQRANTQRGSTGNTM---SRTSGGSNRSPY----GDSSNVKQEPTSPFEQLR--- 217
            .:.:..    .|||.::..:..|.:   .|.||.......    |:....||......|.::
  Fly   532 SEDQQK----VQRALSEFLNHHNELLAWLRASGQHQLQQSVDMGGNLQQAKQFLLQHHELMQDLE 592

  Fly   218 -KGYNNN----KRPAQTSLLSP------PSKKPSLE----EVKEFAEQQRMRKQIAAEYGDNDPE 267
             ||...|    ........|||      .||..||.    |:|:...::.....:..::.:...|
  Fly   593 IKGELINLLLESIKVHLESLSPQERYDVDSKAESLHKHWIELKDLVLKRVDYVSLLIDFFELANE 657

  Fly   268 YDGGMLYDDVHAGDDDDDDMPPQPSTSKQQSPQGTQTQL--------EHGSTTIILK-------Q 317
            ....:        |:....:...|...|.|..|.|.|.:        ..|...|.||       .
  Fly   658 LSSQL--------DNLQRQLQQTPDEHKLQFLQATWTGIASTFGELKSRGQRFINLKIVDPYLET 714

  Fly   318 DSPSQTPTIIVKDSSNAKL-------NHTKIIAEVLRQYPHIVKGHKNIKLKIMPNTPAAPTEKS 375
            .|.:|.....:.|.|..::       |.|..||| .|:..::::       |:|.:......:.:
  Fly   715 KSSAQAVQETLNDFSKRQVDVTSSLENWTTSIAE-KREVEYLLE-------KVMSDNEETVAKST 771

  Fly   376 APATVKPPANQSSATTSPHKKLHVSFKADKSTPLITAQQKAASSQQKSGTSQTTGNQGTGANPP- 439
            ...|...|...|.:..|  |:|.:|.: :|.|.:|...::|....|:  ..|||....|...|.
  Fly   772 QVDTQLYPVFTSQSVDS--KQLLISTR-EKLTNVIQDIERAQDEIQQ--RIQTTLGIQTKDQPSL 831

  Fly   440 ------ANTAAAQKRRIDS-----KTMHALIAQGAENTTGPWLCLRCGV------------NGRP 481
                  .|.....|.::|.     :|:...:.|..||.    :.||..:            :|..
  Fly   832 AKIEQVINNLRMLKAKLDGIKYDYRTLVESVIQFLENI----VQLRREIDDYFARQQKEPASGAD 892

  Fly   482 ISIPSYRGFR-------RHLINTHKETIDPA-LCEHCGWRSVN---------NRELHFHMYMEHQ 529
            .||..:..||       |.||...:..||.. :.|..|.|.::         |..|||    |..
  Fly   893 RSIAEHEKFRDQCMDKFRSLITQSELLIDRVRVLEPPGAREIDTDRILKLLENLRLHF----ESN 953

  Fly   530 TKSLLYTFAECALCNQSYRTKGE-----LEAHINEVHTDDNK------------------QQCIY 571
            :.:.:.|........| :|:..|     |::...::|..:|:                  ::.|.
  Fly   954 SSARMSTLERLEKIEQ-FRSDLEDIDRSLDSVSQQLHEINNQSVDSLAAAKTTSLAFEYFERTIE 1017

  Fly   572 CNKVFEQELQLYRHMKSY----HKEQALEDGI---IDETDEEFLGSQDEEEEAEGDEEQEPEQTG 629
            |:  ..::|:..||.:.:    |..:.||..|   .:.|.::...:..|.|....||.::..:
  Fly  1018 CS--MPRQLKSTRHQRRWGQTAHTIELLEKRIEKFTESTSQQLFITNPESERYVKDELRKLNE-- 1078

  Fly   630 KVRILSDISLPATSAITVQQAQQEQLQEEDVEQVQQEVKFVGADGNEVELTDEQRKEI----LSQ 690
            |.:...|         .|:|.::...|..|..:|             ||..|.:.:||    .|.
  Fly  1079 KWQSFKD---------QVKQKRKSLNQATDFFEV-------------VEKIDAEYREISYFYTSV 1121

  Fly   691 LNQQQAGATAGGVVMVLSEPEAEHVKQETDEKSLAGTEEEYDDSQIYSELGAADSVESAKKNIAD 755
            .|                  :..:::...:..:|....|.|..|:   |......::||.:...|
  Fly  1122 SN------------------KVPYLRDSVEAGNLVNDIENYVTSR---EAALRSKLDSASQCAHD 1165

  Fly   756 ESK------------ESIDNLEWAENLIAE--SEEQSNKEPKSDKPRD-----------DISEKL 795
            .:|            :|...|:...|::.|  .:||..||.:....||           :..|:|
  Fly  1166 MNKVSSLYNDVMNIFQSFIKLKMDINVVQERLKQEQRQKEQRERDARDQAEREKAIKEAEAKERL 1230

  Fly   796 KELTGDWTEDENDDDVDDKPATAELAS-ELANKDPEPTVHEEEDDIDLALQSLHKGPEEATEEK- 858
            ........|::......:: |..|||: |||.:  |..|.|||    ..||::.   |:||.|:
  Fly  1231 HREEQSRLENQRQQAAIEQ-AQRELAARELALR--EQAVREEE----ARLQAIR---EQATREQL 1285

  Fly   859 ASEESVTSADDAVDAVPNINSQPEKMDVDSEAADEKASKAEVQIKKEAE----LENDQEEFIKED 919
            |.|::....:..:.::.:|..:.|::.:.: ..||     |.:|::|.|    .||:.....:|:
  Fly  1286 AREQAAREEELRIQSLRDIARREEEVRLQN-IRDE-----ETRIRREEEERIRRENESRSKREEE 1344

  Fly   920 SPIPHSDSVAELREAVTASEGEDDVHLEADNIRKE-----LLDEL----------IAEAEKPDQE 969
            :.|...    |:....|..:..|...:..:||||:     :..||          :.:|...:.:
  Fly  1345 ARIQRE----EITRLQTLRDQVDQQRIVTENIRKDIQVNSIFTELRYASPLFTRPLKDAVSREGD 1405

  Fly   970 KDIVQSEENATTEALDR------SVTDEDDLVPPTQVSTEQMEIDEP-AAEKA-----AENNEDT 1022
            :.:.:.|...|.|....      |:....|..........::.|:|. ||:.|     |.|...|
  Fly  1406 RFVFECEVTGTPEPAVEWFKDGISIQTNSDYKTTFDKGICRLVIEETFAADSARFSCRASNLVGT 1470

  Fly  1023 RTADEKEAVEDKPNQTQDVTTAEKPTLESAKAGDEATSGEAASVDKVKSLISEWGDDDEDEDE-- 1085
            ...:...:|.:...:.|.|.......|:|.||.:.::...|..|..|.....:|..:|:..|:
  Fly  1471 CDTNATLSVRENAAEVQLVPPRILRFLQSGKATEGSSFQFACVVAGVPLPTVQWFKNDKCIDDSP 1535

  Fly  1086 -------NGVSAAAKEEL 1096
                   ||.:....||:
  Fly  1536 DYVISYNNGEATLKFEEV 1553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	21/88 (24%)
		BTB	31..127	CDD:197585	21/93 (23%)
		C2H2 Zn finger	540..568	CDD:275371	6/50 (12%)
		C2H2 Zn finger	569..586	CDD:275371	4/16 (25%)
zormin	NP_001261317.1	SPEC	126..332	CDD:238103
		SPEC	<504..641	CDD:295325	29/142 (20%)
		COG1340	960..1298	CDD:224259	77/395 (19%)
		RILP-like	<1190..1315	CDD:304877	33/134 (25%)
		MAP7	1233..1365	CDD:283355	36/151 (24%)
		I-set	1390..1479	CDD:254352	14/88 (16%)
		IGc2	1403..1469	CDD:197706	12/65 (18%)
		I-set	1491..1580	CDD:254352	14/63 (22%)
		IGc2	1504..1570	CDD:197706	10/50 (20%)
		I-set	1589..1675	CDD:254352
		Ig	1605..1675	CDD:299845
		I-set	1702..1786	CDD:254352
		Ig	1713..1786	CDD:299845
		I-set	1811..1902	CDD:254352
		Ig	1828..1892	CDD:143165
		I-set	1927..2015	CDD:254352
		IGc2	1940..2005	CDD:197706
		I-set	2142..2231	CDD:254352
		Ig	2158..2231	CDD:299845
		I-set	2238..2325	CDD:254352
		Ig	2254..2324	CDD:299845
		I-set	3566..3655	CDD:254352
		Ig	3583..3650	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900