DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cp190 and Zbtb5

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001156755.1	Gene:	Zbtb5 / 230119	MGIID:	1924601	Length:	670	Species:	Mus musculus

Alignment Length:	749	Identity:	152/749 - (20%)
Similarity:	242/749 - (32%)	Gaps:	282/749 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 QNFFNKTDY-------CDLTLQFRDNSQLKVHRLVLSACTDYFNVL------EQTCEIV--DDAL 70
            :..|.:.:|       ||..:.. .|...|.||.||:||:.:|..|      :||..::  |..:
Mouse     8 EQIFQQLNYQRLHGQLCDCVIVV-GNRHFKAHRSVLAACSTHFRALFSVAEGDQTMNMIQLDSEV 71

  Fly    71 IMPNEFQADVVVPIVNFMYTGTLEFELKMYGK-----LLRTAKEMNMTVLLKLLEAHRRTMENVN 130
            :....|.|     :::.|||.||     |.|:     :|..|..:::..::|..:.:..|
Mouse    72 VTAEAFAA-----LIDMMYTSTL-----MLGESNVMDVLLAASHLHLNSVVKACKHYLTT----- 121

  Fly   131 RQQRPPSPKGIRRRTVGQPSSGLPQQRVLGPSPQSRNVATPIAQRANTQRGSTGNTMSRTSGGSN 195
                                      |.|..||.|....   .|.|..||    :.|.:..|.|.
Mouse   122 --------------------------RTLPMSPSSERAQ---EQSARMQR----SFMLQQLGLSI 153

  Fly   196 RSPYGDSSNVKQEPTSPFEQLRKGYNNNKRPAQTSLLSPPSKKPSLEEVKEFAEQQRMR------ 254
            .|....||...:|||:|.....:...:.:.|.....|.  .:|.|:||    ..:||:|
Mouse   154 VSSALSSSQSAEEPTAPMSSSMRSSLDQRTPFPMRRLH--KRKQSVEE----RARQRLRSSMEES 212

  Fly   255 --KQIAAEYG-------------------DN-------DPEYDGGMLYDDVHAGDDDDDDMPPQP 291
              ..:..|.|                   ||       |.:.||.|::|... |..:|..:|.|.
Mouse   213 AISDVTPESGPAGVHSREEFFSPDSLKIVDNPKPDGMADNQEDGAMMFDRPF-GAQEDAQVPSQS 276

  Fly   292 STSK-QQSPQGTQTQ--------LEHGS---------------TTIILKQDSPSQTP-------- 324
            ..|. ..:.:.||.:        .|.||               ..:::|.: |..:|
Mouse   277 DGSAGNMASRATQVETSFEQEAVAEKGSFQCENPEVGLGEKEHMRVVVKSE-PLSSPEPQDEVSD 340

  Fly   325 -TIIVKDSSNAKLNHTKIIAEVLRQYP--------------------HIVKGHKNIKLKI----- 363
             |...:.|.:.::....:.||.:...|                    ||::...|::.|.
Mouse   341 VTSQAEGSESVEVEGVVVSAEKIDLSPESSDRSFSDPQSSTDRVGDIHILEVTNNLEHKTSFSIS 405

  Fly   364 --------------------MPNTPA-APTEKSAPATVKP---PANQSSATTSPHKKLHVSFKAD 404
                                :|||.: ...|..||..:.|   ||...|:....|.:...|..||
Mouse   406 NFLNKSRGSNFSASQSTDDNLPNTTSDCRLEGEAPYLLSPEAGPAGGPSSAPGSHVENPFSEPAD 470

  Fly   405 KS--TPLITAQQKAASSQQKSGTS--QTTGNQG---------TGANPPANTAAAQK--------- 447
            ..  .|:          |:..|..  ||:|.||         :|....::.:.|..
Mouse   471 SHFVRPM----------QEVMGLPCVQTSGYQGEQFGMDFSRSGLGLHSSFSRAMMGSPRGGASN 525

  Fly   448 ----RRIDSK---TMHALIAQGAENTTGPWLCLRCGVNGRPISIPSYRGFRRHLINTHKETIDP- 504
                |||..|   ......:|.:||:....|.:    ||    ..|:.       |.|.....|
Mouse   526 FPYYRRIAPKMPVVTSVRSSQISENSASSQLMM----NG----ATSFE-------NGHTSQPGPP 575

  Fly   505 ---------------ALCEHCGWRSVNNRELHFHMYMEHQTKSLLYTFAECALCNQSYRTKGELE 554
                           ||.||    :|        :.:|...|     :| |.:|.:::.|..:.:
Mouse   576 QLTRASADVLSKCKKALSEH----NV--------LVVEGARK-----YA-CKICCKTFLTLTDCK 622

  Fly   555 AHINEVHTDDNKQQCIYCNKVFEQELQLYRHMKS 588
            .|| .|||.:....|:.|.|.|.|...||:|.|:
Mouse   623 KHI-RVHTGEKPYACLKCGKRFSQSSHLYKHSKT 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	29/120 (24%)
		BTB	31..127	CDD:197585	27/108 (25%)
		C2H2 Zn finger	540..568	CDD:275371	8/27 (30%)
		C2H2 Zn finger	569..586	CDD:275371	7/16 (44%)
Zbtb5	NP_001156755.1	BTB	14..119	CDD:279045	28/115 (24%)
		BTB	25..119	CDD:197585	26/104 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..256		20/103 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	268..382		17/114 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..433		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..470		6/27 (22%)
		C2H2 Zn finger	608..628	CDD:275368	5/20 (25%)
		zf-H2C2_2	620..645	CDD:290200	9/25 (36%)
		C2H2 Zn finger	636..655	CDD:275368	8/18 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24394
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100