DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cp190 and Rp1

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_035413.1	Gene:	Rp1 / 19888	MGIID:	1341105	Length:	2095	Species:	Mus musculus

Alignment Length:	1217	Identity:	228/1217 - (18%)
Similarity:	401/1217 - (32%)	Gaps:	371/1217 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 FNVLEQTCEIVDDALIMPNEFQADVV------------VPIVNFMYTGTLEFELKMYGKLLRTAK 108
            ||:||:     |..::....||.:.|            ||.||.::. .|..:.|..|..|::..
Mouse   806 FNILEE-----DQKVLHRPPFQVEKVARNLKGMAKKSLVPKVNDLHI-MLRNQKKQMGVKLKSGA 864

  Fly   109 EMNMTVLLKLLEAHRRT-MENVNRQQRPPSPKGIRRRTVG--------QPSSGLP--QQRVLGPS 162
            |::        |.|..| .:.:...::|..|:||...: |        |..:..|  :.|..||.
Mouse   865 EVS--------EQHVTTRADPLASLKKPDFPEGIPHHS-GKSYVKRWLQNINSYPDFEHRKSGPL 920

  Fly   163 PQSRNVATPIAQRANTQR-GSTGNTMSRTSG-------GSNRSPYGD---SSNVKQEPTSPF--- 213
            .|:|      :...|..| |..||.:..||.       .||:|...:   |.|..||.....
Mouse   921 CQNR------SDVVNYNRNGFLGNNLHTTSSKGNGFLMESNKSKTKNDNWSGNTNQETGKSLVAK 979

  Fly   214 ---EQLRKGY----------------NNNKRPAQTSLLSPPSK-----KPSLEEVK------EFA 248
               |:|.|.:                ::|...:||::..|.:|     :.|..|||      .||
Mouse   980 DNGEELNKHHCESQNGSLYDSYLVSLHDNCTLSQTTINEPSTKSHLSIEKSRPEVKLVYQEMNFA 1044

  Fly   249 EQQRMRKQIAAE---YGDND-PEYDGGMLYDDVHAGDDDDDDMPPQPSTSKQQSPQGTQTQLEHG 309
             .:|...::|.:   .|:|. .:|...:|...:.|            .....|..|...:|:...
Mouse  1045 -TKRQSIEVAIQVDTMGENVLKDYLPALLLRHLEA------------FVPNNQKHQNGISQIPGS 1096

  Fly   310 STTIILKQDSPSQTPTIIVKDSSNAKLNHTKIIAEVLRQYPHIVKGHKNIKLKIMPNTPAAPTEK 374
            ...::.        |::|...|:|..|....::               |:| :.|.:...:...|
Mouse  1097 LAEVVF--------PSVIDNSSTNLLLAWLLVL---------------NLK-RTMNSFCQSDAHK 1137

  Fly   375 SAPATVKPPANQSSATTSPHKKLHVSFKADKSTPLITAQQKAASSQQKSGTSQTTGNQGTGANP- 438
               .|.:|  ::::|.....|.:.::.:||        ..|||.:.....|...:|:.|...:.
Mouse  1138 ---MTNRP--SETAALLEVLKHVAITEEAD--------DLKAAVANLMESTKTCSGSSGREQDML 1189

  Fly   439 PANTAAAQKRRIDSKTMHALIAQGAENTTGPWLCLRCGVNGRPISIPSYRGFRRHLINTHKETID 503
            |.|..|:....:|                      .|..||                :..|..:|
Mouse  1190 PVNCTASSLHSVD----------------------ECNENG----------------SAQKTLLD 1216

  Fly   504 P--ALCEHCGWRSVN---NRELHFHM--------YMEHQTKSLLYTFAECALCNQSYRTKGELEA 555
            .  ::...|....|:   |.....||        .::.|:..||.:.:    |..|.|:.|
Mouse  1217 EGYSVMGDCTSEMVSKSCNSSCEMHMVSKTNPPKQVDDQSDGLLTSNS----CTVSQRSTG---- 1273

  Fly   556 HINEVHTDDNKQQCIYCNKVFEQELQLYRHMKSYHKEQALEDGII-DET-----DEEFLGSQDEE 614
                        .|...:.|       |.|.....||...|...: |||     |...:.|...:
Mouse  1274 ------------ACFLTDGV-------YSHEACAQKEGVYEGACLSDETHIPIRDCHTIHSVHSK 1319

  Fly   615 EEAEGDEEQEPEQTGKV-------RILSDISLPATSAITVQQ----------------------- 649
            |....|:.:..|:...|       .||:|......|.::..|
Mouse  1320 ENKCTDDLESTEELKTVDKVPKGLSILADSMYKNDSNVSTFQNVNKLSSQRTLLSKTYLDSDKDY 1384

  Fly   650 AQQEQLQEEDVEQVQQEVKFVGADGNEVELTDEQRKEILSQLNQQQAGATAGGVVMVLSEPEA-- 712
            :..|:.|....:::..:.|.:.:| .|...|.|:.:.|.:.:...:..|        :||.|:
Mouse  1385 SPLEEFQNCPRKKIVNKKKSISSD-KEESRTSEEPRSITNSMTSSERNA--------ISELESFE 1440

  Fly   713 EHVKQET---------DEKSLAGTEEEYDDSQIYSEL---GAADSVESAKKNIA----------- 754
            |...|:|         ::||...|.::..::::.|||   .....:|..::|.|
Mouse  1441 ELESQDTSIFNMNVRAEKKSTKETMQKQSEARMSSELINVSGRKIIEQERRNTAILETTARGQVT 1505

  Fly   755 --------DESKESIDNLEWAENLIAESEEQSN-KEPKSDKPRDDISEKLKEL--------TGDW 802
                    |.:|.:       |..|:|.|.:.. |:.......:..||.....        |.||
Mouse  1506 PPSLAFCYDSNKNT-------EKEISEGETKMRVKKMVDSMENESYSESSLNFKKHHRSPGTLDW 1563

  Fly   803 TEDENDDDVDDKP--ATAELASELANKDPEPTVHEEEDDIDLALQSLHKGPEEATEEKASEESVT 865
            : |...|.....|  |::...::.:.::.|||    ...:..|::.|: |..|..:......|:.
Mouse  1564 S-DYGSDSESGYPCKASSNSHNDDSGQEKEPT----RGIVKRAIEKLY-GKAEIIKPPFFHGSIH 1622

  Fly   866 SAD----DAVDAVPNINSQPEKMDVDSEAADEKASKAEVQIKKEAELENDQEEFIKEDSPIPHSD 926
            .:.    ::|:......:...:.:..|..:.|:.|::.:..::..:::.:.......||.|
Mouse  1623 KSQVCPYNSVEVQCAKKTNFYESECQSLVSSEQVSRSSLIFQEFPQVDANGMGDSFGDSSI---- 1683

  Fly   927 SVAELREAVTASEGEDDVHLEADNIRKELLDE---LIAEAEKPDQEKDIVQSEENATTEALDRSV 988
                  |.||.|...|.|..|.:|  .:|:|.   |:.|........|......||.|.::|..:
Mouse  1684 ------ENVTKSSAHDRVFTEKEN--GKLIDNGKWLLRENHLWRVSSDNPGMYGNADTTSVDTLI 1740

  Fly   989 TDEDDLVP----------PTQVSTEQMEIDE--------------PAAEKAAENNEDTRTADEKE 1029
            ......||          ||.......||:|              |....:....||...|..|.
Mouse  1741 DKNSIEVPYSHFGELAPGPTMAELSSSEIEEMTQPLEVKCNYFNFPHGSDSEPFGEDFPDAQNKT 1805

  Fly  1030 AVEDK-PNQTQDVTTAEKPTLESAKAGDEATSGEAASVDKVKSLISE 1075
            ..::| ||.    .|.||....|.:.....|....::.:||..:.|:
Mouse  1806 CPKEKIPNH----HTEEKGNYPSERLCTSVTQAFVSAGNKVHPVCSD 1848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	18/77 (23%)
		BTB	31..127	CDD:197585	20/83 (24%)
		C2H2 Zn finger	540..568	CDD:275371	4/27 (15%)
		C2H2 Zn finger	569..586	CDD:275371	3/16 (19%)
Rp1	NP_035413.1	DCX	35..110	CDD:176357
		DCX	157..232	CDD:176357
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..379
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	643..688
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..887		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1400..1430		6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1572..1595		5/26 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900