DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cp190 and Zbtb7a

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	XP_006513342.3	Gene:	Zbtb7a / 16969	MGIID:	1335091	Length:	725	Species:	Mus musculus

Alignment Length:	673	Identity:	127/673 - (18%)
Similarity:	200/673 - (29%)	Gaps:	229/673 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 CDLTLQFRDNSQLKVHRLVLSACTDYFNVLEQTCEIVDDALIMPNEF-QADVVVPIVNFMYTGTL 93
            ||:.: ..:..:...||.||:||:.||..|..:..:||...:...:| .|:.:..:::|.||.||
Mouse   190 CDVVI-LVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALMDFAYTATL 253

  Fly    94 EFELKMYGKLLRTAKEMNMT----VLLKLLEAHRRTMENVNRQQRPPSPKGIRRRTV-------- 146
            .......|.:|..|:.:.:.    |...|||......::|....:|.......:|.:
Mouse   254 TVSTANVGDILSAARLLEIPAVSHVCADLLERQILAADDVGDASQPDGAGPTDQRNLLRAKEYLE 318

  Fly   147 ---GQPSSGLPQQRV----LGPSPQSRNVATPIAQRANTQRGSTGNTMSRTSGG----SNRSPYG 200
               ..|.:.||....    .| :|.....||..|..|.....:.|:.......|    ::|.|.|
Mouse   319 FFRSNPMNSLPPTAFPWSGFG-APDDDLDATKEAVAAAVAAVAAGDCNGLDFYGPGPPADRPPAG 382

  Fly   201 DSSNVKQEPTSPFEQLRKGYNNNKRPAQTSLLSPPSKKPSLEEVKEFA--------EQQRMRKQI 257
            |.......|     .|....:.:..|.  .|..||:..|:..:...:.        |:.....:.
Mouse   383 DGDEGDSTP-----GLWPERDEDAPPG--GLFPPPTAPPATTQNGHYGRAGAGTGEEEAAALSEA 440

  Fly   258 AAEYGDNDPEYDGGMLYDDVHAGDDDDDDMPPQPSTSKQQSPQGTQTQLEHGSTTIILKQDSPSQ 322
            |.|.||:.....|....:|..|.|.|.               ....|.|:...:::....||..:
Mouse   441 APEPGDSPGFLSGAAEGEDGDAADVDG---------------LAASTLLQQMMSSVGRAGDSDEE 490

  Fly   323 TPT-------IIVKDSSNAKLNHTKIIAEVLRQYPHIVKGHKNIKLKIMPNTPAAPTEKSAPATV 380
            :.|       ..:|..|.|   |...:.....|     ||.|.|:.|.....|..  ||......
Mouse   491 SRTDDKGVMDYYLKYFSGA---HEGDVYPAWSQ-----KGEKKIRAKAFQKCPIC--EKVIQGAG 545

  Fly   381 KPPANQSSATTSPHKKLHVSFKADKSTPLITAQQKAASSQQKSGTSQTTGNQGTGANP-PANTAA 444
            |.|.         |.:.|                                   ||..| ..|...
Mouse   546 KLPR---------HIRTH-----------------------------------TGEKPYECNICK 566

  Fly   445 AQKRRIDSKTMHALIAQGAENTTGPWLCLRCGVNGRPISIPSYRGFRRHLINTHKETIDPALCEH 509
            .:..|.|...:|                                 .|:|   |.::   |.||:.
Mouse   567 VRFTRQDKLKVH---------------------------------MRKH---TGEK---PYLCQQ 592

  Fly   510 CGWRSVNNRELHFHMYMEHQTKSLLYTFAECALCNQSYRTKGELEAHINEVHTDDNKQQCIYCNK 574
            ||....:|.:|..||                                  .|||.....||..|.|
Mouse   593 CGAAFAHNYDLKNHM----------------------------------RVHTGLRPYQCDSCCK 623

  Fly   575 VFEQELQLYRHMKSYHKE-----------------------------QALEDGIIDETDEEFLGS 610
            .|.:...|:||:|   |:                             ..|.|...:..::.|
Mouse   624 TFVRSDHLHRHLK---KDGCNGVPSRRGRKPRVRGVPPDVPAGAGAPPGLPDAPRNGQEKHF--- 682

  Fly   611 QDEEEEAEGDEEQEPEQTGKVRI 633
            :||||:   :||..|:.:|::.:
Mouse   683 KDEEED---EEEASPDGSGRLNV 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	27/96 (28%)
		BTB	31..127	CDD:197585	26/100 (26%)
		C2H2 Zn finger	540..568	CDD:275371	3/27 (11%)
		C2H2 Zn finger	569..586	CDD:275371	6/16 (38%)
Zbtb7a	XP_006513342.3	BTB_POZ_ZBTB7A	165..284	CDD:349635	25/94 (27%)
		C2H2 Zn finger	534..554	CDD:275368	6/30 (20%)
		zf-H2C2_2	549..571	CDD:404364	6/65 (9%)
		C2H2 Zn finger	562..582	CDD:275368	5/52 (10%)
		zf-H2C2_2	575..599	CDD:404364	9/62 (15%)
		C2H2 Zn finger	590..610	CDD:275368	7/53 (13%)
		zf-H2C2_2	602..627	CDD:404364	11/58 (19%)
		C2H2 Zn finger	618..636	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24394
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100