DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cp190 and Hic1

DIOPT Version :10

Sequence 1:NP_524359.2 Gene:Cp190 / 41848 FlyBaseID:FBgn0000283 Length:1096 Species:Drosophila melanogaster
Sequence 2:NP_001091673.1 Gene:Hic1 / 15248 MGIID:1338010 Length:733 Species:Mus musculus


Alignment Length:835 Identity:157/835 - (18%)
Similarity:248/835 - (29%) Gaps:301/835 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 LQKLQNFFNKTDYCDLTLQFRDNSQLKVHRLVLSACTDYFNVLEQTCEIVDDALIMPNEFQADVV 81
            |.:|.|...|...||:.:..: |:..:.|:.||:|.:.|...|     :|.|.|:   ....|:|
Mouse    34 LLQLNNQRTKGFLCDVIIVVQ-NALFRAHKNVLAASSAYLKSL-----VVHDNLL---NLDHDMV 89

  Fly    82 VP-----IVNFMYTGTLEFELK-------------MYGKLLRTAKEMNMTVLL----KLLEAHRR 124
            .|     :::|:|||.|...::             ..|.:|..|..:.:..|:    |.|:.|.:
Mouse    90 SPAVFRLVLDFIYTGRLTDSVEAAAAAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGK 154

  Fly   125 TME---------NVNRQQRP---------------PSPKGIRRRTVGQPSSGLPQQRV------- 158
            ...         ......||               .||.|.......:|.|| |...|       
Mouse   155 YCHLRGGGSGGGGYAPYGRPGRGLRAATPVIQACYSSPAGPPPPPAAEPPSG-PDAAVNTHCAEL 218

  Fly   159 --LGPSPQSRNVA-----TPIAQRANTQRGSTGNTM------SRTSGGSNRSPYGDSSNVKQEPT 210
              .||.|.:...|     :|:.....:::...|:::      .|.......||.|....|.:||:
Mouse   219 YASGPGPAASLCAPERRCSPLCGLDLSKKSPPGSSVPERPLSERELPPRPDSPPGAGPAVYKEPS 283

  Fly   211 --------SPFEQLRKGYNNNKRPAQTSLLSPPSKKPSLEEVKEFAEQQRMRKQIAAEYGDN--- 264
                    .||::|.:.. ....|.:.|..||..:.|...:......:....:.....|||.   
Mouse   284 LALPPLPPLPFQKLEEAV-PTPDPFRGSGGSPGPEPPGRPDGSSLLYRWMKHEPGLGSYGDELVR 347

  Fly   265 -----------------------------DPEYDGGMLYDDVHAGDDDDD--DMPPQPSTSKQQS 298
                                         .|.|.|.:  |....|.|.||  ....:..:|:..|
Mouse   348 DRGSPGERLEERGGDPAASPGGPPLGLVPPPRYPGSL--DGPGTGADGDDYKSSSEETGSSEDPS 410

  Fly   299 PQGTQTQLEHGSTTIILKQDSPSQTPTIIVKDSSNAKLNHTKIIAEVLRQY--PHIVKGH----- 356
            |.|                                   .|       |..|  ||:..|.     
Mouse   411 PPG-----------------------------------GH-------LEGYPCPHLAYGEPESFG 433

  Fly   357 KNIKLKIMPNTPAAPTEKSAPATVKPPANQSSATTSPHKKLHVSFKADKSTPLITAQQKAASSQQ 421
            .|:.:.|       |..|..|         ||...:.|.:.||             :::.|...:
Mouse   434 DNLYVCI-------PCGKGFP---------SSEQLNAHVEAHV-------------EEEEALYGR 469

  Fly   422 KSGTSQTTGNQGTGANPPANTAAAQKRRIDSKTMHALIAQGAENTTG----------PWLCLRCG 476
            ........|..|.|  ||                   ...|.:..||          |:.|..|.
Mouse   470 AEAAEVAAGAAGLG--PP-------------------FGGGGDKVTGAPGGLGELLRPYRCASCD 513

  Fly   477 VNGRPISIPSYRG---FRRHLINTHKETIDPALCEHCG----WRSVNNRELHFHMYMEHQTKSLL 534
                    .||:.   .|:| ..||..| .|..|..||    .|....|.:..|:.::       
Mouse   514 --------KSYKDPATLRQH-EKTHWLT-RPYPCTICGKKFTQRGTMTRHMRSHLGLK------- 561

  Fly   535 YTFAECALCNQSYRTKGELEAHINEVHTDDNKQQCIYCNKVFEQELQLYRHMKSYHKEQAL-EDG 598
             .|| |..|...:..:..|..|: .:|:.:...:|..|...|.|:..|..|||.:....|. ..|
Mouse   562 -PFA-CDACGMRFTRQYRLTEHM-RIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAG 623

  Fly   599 IIDETDEEFLGSQDEEEEAEGDEEQEPEQTGKVRILSDISLPATSAITVQQAQQEQLQEED---- 659
            .:               ...|.....|...||.::.....:.|.:.:|   |:|..|:::|    
Mouse   624 AL---------------AGLGGLPGVPGPDGKGKLDFPEGVFAVARLT---AEQLSLKQQDKAAA 670

  Fly   660 -----------------VEQVQQEVKFVGADGNEVELTDEQRKEILSQLNQQQAG 697
                             :|.:....||..    |:.|:.::..|:|||.....||
Mouse   671 AELLAQTTHFLHDPKVALESLYPLAKFTA----ELGLSPDKAAEVLSQGAHLAAG 721

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cp190NP_524359.2 BTB_POZ_CP190-like 16..125 CDD:349620 31/129 (24%)
COG5236 <471..>594 CDD:227561 31/129 (24%)
C2H2 Zn finger 540..568 CDD:275371 5/27 (19%)
C2H2 Zn finger 569..586 CDD:275371 5/16 (31%)
PTZ00121 <709..1075 CDD:173412
Hic1NP_001091673.1 BTB_POZ_ZBTB29_HIC1 26..155 CDD:349642 31/129 (24%)
Mediates HDAC-dependent transcriptional repression. /evidence=ECO:0000250 154..315 29/162 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 189..209 7/20 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 241..421 34/224 (15%)
Interaction with CTBP1. /evidence=ECO:0000250 241..247 0/5 (0%)
COG5048 <501..613 CDD:227381 32/131 (24%)
C2H2 Zn finger 509..529 CDD:275368 6/28 (21%)
zf-C2H2 535..557 CDD:395048 5/21 (24%)
C2H2 Zn finger 537..557 CDD:275368 5/19 (26%)
C2H2 Zn finger 565..585 CDD:275368 4/20 (20%)
zf-H2C2_2 577..602 CDD:463886 6/25 (24%)
C2H2 Zn finger 593..613 CDD:275368 8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

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