DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cp190 and zbtb42

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	XP_017207217.2	Gene:	zbtb42 / 101884211	ZFINID:	ZDB-GENE-130730-2	Length:	463	Species:	Danio rerio

Alignment Length:	608	Identity:	106/608 - (17%)
Similarity:	181/608 - (29%)	Gaps:	250/608 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QKLQNFFNKTDYCDLTLQFRDNSQLKVHRLVLSACTDYFNVLEQTCEIVDDALIMPNEFQADVVV 82
            |:.|.|.     ||.|:...: ::.:.||.||::|:.||::..:......|.:::    .:|:|.
Zfish    61 QRQQGFL-----CDCTVLVGE-TRFRAHRAVLASCSMYFHLYYRDQLDKRDVVLL----NSDIVT 115

  Fly    83 P-----IVNFMYTGTLEFELKMYGKLLRTAKEMNMTVLLKLLEAHRRTMENVNRQQRPPSPKGIR 142
            .     ::.|||.|.|||.......:|..|..::|..::|:.:
Zfish   116 VSAFSLLLEFMYEGKLEFSAIPVEDVLAAASYLHMYDIVKVCK---------------------- 158

  Fly   143 RRTVGQPSSGLPQQRVLGPSPQSRNVATPIAQRANTQRGSTGNTMSRTSGGSNRSPYGDSSNVKQ 207
                                                                        |.:|:
Zfish   159 ------------------------------------------------------------SKLKE 163

  Fly   208 EPTSPFEQLRKGYNNNKRPAQTSLLSPPSKKPSLEEVKEFAEQQRMRKQIAAEYGDNDPEYDGGM 272
            :...|.||.:.  |.....|:|.:|:....|   ..|...|..||.|
Zfish   164 KELLPEEQQKA--NGVNYVAETCVLTAGKTK---AHVSSSASSQRSR------------------ 205

  Fly   273 LYDDVHAGDDDDD---DMPPQPSTSKQQSPQGTQTQLEHGSTTIILKQDSPSQTPTIIVKDSSNA 334
                     ||.|   |:..:|....:.|.|              |..||..|....:||:..
Zfish   206 ---------DDTDCALDLSLKPVWIGEFSGQ--------------LALDSQQQDTQTLVKEQH-- 245

  Fly   335 KLNHTKIIAEVLRQYPHIVKGHKNIKLKIMPNTPAAPTEKSAPATVKPPANQSSATTSPHKKLHV 399
                     :||.:....              .||:|..:      :...|..||..:...:|
Zfish   246 ---------DVLSEQEDA--------------DPASPESR------RFGNNGRSAAVTGFSEL-- 279

  Fly   400 SFKADKSTPLITAQQKAASSQQKSGTSQTTGNQGTGANPPANTAAAQKRRIDSKTMHALIAQGAE 464
             |..:|...|:..:.....||::.|.|:....:...::             |..|...::...|
Zfish   280 -FPRNKHEDLMEEELSGVRSQRQLGDSEGDDEEDLASS-------------DISTSSGVLLSSA- 329

  Fly   465 NTTGPWLCLRCGVNGRPISIPSYRGFRRHLINTH-----------KETIDP----ALCEHCGWRS 514
               |..:|: |.:..:....|       |::..|           :..:.|    ..|..||
Zfish   330 ---GAQVCV-CPLCSKVFPNP-------HVLQLHLSSHFREKDGVRSKLSPDGSVPTCSQCG--- 380

  Fly   515 VNNRELHFHMYMEHQTKSLLYTFAE------------CALCNQSYRTKGELEAHINEVHTDDNKQ 567
                          :|.|.:||...            ||.|.:|::....|..|. .|||.:...
Zfish   381 --------------KTFSCMYTLKRHERTHSGEKPYTCAQCGKSFQYSHNLSRHA-VVHTREKPH 430

  Fly   568 QCIYCNKVFEQELQLYRHMKSYH 590
            .|.:|.:.|.|...||||::.:|
Zfish   431 ACKWCERRFTQSGDLYRHIRKFH 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	26/106 (25%)
		BTB	31..127	CDD:197585	23/100 (23%)
		C2H2 Zn finger	540..568	CDD:275371	9/27 (33%)
		C2H2 Zn finger	569..586	CDD:275371	7/16 (44%)
zbtb42	XP_017207217.2	BTB	58..165	CDD:306997	29/195 (15%)
		zf-C2H2_8	334..420	CDD:318181	18/110 (16%)
		C2H2 Zn finger	336..356	CDD:275368	4/26 (15%)
		C2H2 Zn finger	376..396	CDD:275368	7/36 (19%)
		zf-H2C2_2	389..411	CDD:316026	3/21 (14%)
		C2H2 Zn finger	404..424	CDD:275368	6/20 (30%)
		C2H2 Zn finger	432..450	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24394
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100