DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cp190 and zbtb3

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001116908.1	Gene:	zbtb3 / 100144674	XenbaseID:	XB-GENE-991962	Length:	709	Species:	Xenopus tropicalis

Alignment Length:	760	Identity:	148/760 - (19%)
Similarity:	248/760 - (32%)	Gaps:	223/760 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QKLQNFFNKTDYCDLTLQFRDNSQLKVHRLVLSACTDYFNVLEQTCEIVDDALIMPNEFQADVVV 82
            |:||.|.     ||..: ....:....||.||::|:.:|::   :|....|...:....|. |..
Frog    17 QQLQGFL-----CDCQV-IVGTAHFLAHRSVLASCSPFFHM---SCREHPDTRDLTLNSQI-VTA 71

  Fly    83 P----IVNFMYTGTLEFELKMYGKLLRTAKEMNMTVLLKLLEA---------------------- 121
            |    ::||||.|.|.|:......:|..|..::|..::::.:.
Frog    72 PAFSLLLNFMYCGRLSFQEAPAEDVLAAASYLHMDEVVRVCKKRLQGRAPAEADSTRREEESSTA 136

  Fly   122 -HRRTMENVNRQQR--PPSPKGIRR-RTVGQPSSGLPQ----------QRVLGPSPQSRNVATPI 172
             |....|:|...|.  .....|.|. |..|:.:.|..|          |...|.|...|..|...
Frog   137 YHLAESEDVKMGQHGMECGQSGTRNLRCQGEEAEGSEQKVPGNVVFQMQEGAGSSRFHRQEAVGT 201

  Fly   173 AQR-------------ANTQR--------------------GSTGNTMSRTSG------GSNRSP 198
            .||             .|.||                    ||:|..:...:|      ||.|.
Frog   202 GQRVAGSLSYQAQELSGNGQRIAVSSRTESFTMVEGGQEVAGSSGFDIQEGTGSGHSVVGSARG- 265

  Fly   199 YGDSSNVKQEP---TSPFEQLRKGYNNNKRP---------AQTSLLSPPSKKPSLEEVKEFAEQQ 251
            :|....|..:.   ||.||..::..|....|         |..|.::||:.:...|.....|..|
Frog   266 HGQQLTVSHQEVAGTSRFEVQKRTENEQPVPESIKYQQQDAPQSTVTPPTHRYPTENQDTCANAQ 330

  Fly   252 RMRKQIAAEYGDNDPEYD----------GGMLY-----DDVHAGDDDDDDMPPQPSTSKQQSPQG 301
                   |....|.|:..          ||..|     :.||.    ::.:...|..|.:...:.
Frog   331 -------AAPSRNSPKRQEPAGSTQGPMGGSRYSLQSQESVHI----NNQVLSLPRLSLENQTEA 384

  Fly   302 TQTQLEHGSTTIILKQDSPSQTPTIIVKDSSNAKLNHTKIIAEVLRQYPHIVKGHKNIKLKIMPN 366
            ..|....||....::...|: ..|:....:|...:...:.......|     .|...|.|:....
Frog   385 GTTLSVSGSFRYSMQTSEPT-VSTMATPGTSRYCVQSPQFAGNTTVQ-----PGTSRISLQTQEP 443

  Fly   367 TPA---APTEKSAPATVKPPANQSSATTSPHKKLHVSFKADKSTPLITAQQKAASSQQKSGTSQT 428
            |.:   ||......:.|:.|.  .|.:|:|          ..|...:.:.:.|.::|..:|||:
Frog   444 TGSMQLAPARPRYTSQVQEPT--GSISTAP----------GLSRYFLQSSESAGTTQAVAGTSR- 495

  Fly   429 TGNQGTGANPPANTAAAQKRRIDSKTMHALIAQGAENTTGPWL--------CLRCGVNGRPISIP 485
                   .:.|.:.:.|:|:|.:.....:.:|  ...||.|.:        |...|....|.|..
Frog   496 -------YSLPTSGSLAEKQREEGDCAKSELA--VTTTTQPGMETAAASSPCSSTGSEVHPASGV 551

  Fly   486 SYR----------------GFRRHLINTHKETIDPALC----------EHCGWRSVNNRELHFH- 523
            :.:                .|:||.....:...:.:..          .|.|:.::..:.:|..
Frog   552 TVKVEAIVISDEECERGPGSFKRHDFEEEEGEEESSYLPYHMIAVPGGHHPGYGTLLPQSIHAET 616

  Fly   524 MYME----HQTKSLLYTFAE----CALCNQSYRTKGELEAHINEVHTDDNKQQCIYCNKVFEQEL 580
            ||::    |....|   |.|    |..|.:::.....|..|.. |||.:...:|.||.:.:.|..
Frog   617 MYLQDFEGHPGFPL---FPEDVPTCKTCGKTFSCSYTLRRHAT-VHTRERPYECRYCLRSYTQSG 677

  Fly   581 QLYRHMKSYHKEQALEDGIIDETDEEFLGSQDEEEEAEGDEEQEP 625
            .||||::..|.:  ||..:               ::.:|:.|..|
Frog   678 DLYRHIRKAHSQ--LEPSL---------------KKPKGEMEPAP 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	26/128 (20%)
		BTB	31..127	CDD:197585	23/122 (19%)
		C2H2 Zn finger	540..568	CDD:275371	7/27 (26%)
		C2H2 Zn finger	569..586	CDD:275371	7/16 (44%)
zbtb3	NP_001116908.1	BTB_POZ_ZBTB3	1..127	CDD:349632	27/119 (23%)
		PRK10905	293..>503	CDD:236792	43/246 (17%)
		DUF5585	<382..>642	CDD:375359	49/290 (17%)
		C2H2 Zn finger	638..658	CDD:275368	4/20 (20%)
		zf-H2C2_2	651..675	CDD:372612	8/24 (33%)
		C2H2 Zn finger	666..684	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24394
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100