DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cp190 and znf281a

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	XP_001922388.3	Gene:	znf281a / 100005963	ZFINID:	ZDB-GENE-131126-34	Length:	849	Species:	Danio rerio

Alignment Length:	937	Identity:	179/937 - (19%)
Similarity:	309/937 - (32%)	Gaps:	280/937 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 QQRMRKQIAAEYGDNDPEYDGGMLYDDVHAGDDDDDDMPPQPSTSKQQSPQGTQTQLEHGSTTII 314
            |.::..:.....|..:|.:...||.         ...:||..|.::..| |....:|:.....:.
Zfish     5 QDKLGNEFLRSNGGMEPGFGASMLM---------FSHLPPVTSFTRLAS-QTVMAELQPHEMILK 59

  Fly   315 LKQDSPSQTPTIIVKDSSNAKLNHTKIIA--------EVLRQYPHI--VKGHK----NIKLKIMP 365
            .::|||.        ..:...||...::|        ..:..|.|.  :|..|    :.:|.:.|
Zfish    60 KERDSPD--------CGAGGGLNTGGMVAGGGIGGMMGNVGDYVHAMGIKQEKVSEHDYRLPLYP 116

  Fly   366 NTPAAPTEKSAPATVKPPANQSSATTSPHKKLHVSFKADKSTPLITAQQKAASSQQKSGTSQTTG 430
            .|       ...|.|:........:...|:.|.|.   |.|...::.:.          ..:::|
Zfish   117 GT-------GTGAGVRSGGELLEVSLGNHQNLVVH---DLSLGNLSGRL----------VKESSG 161

  Fly   431 NQGTGANPPANTAAAQKRRIDSKTMHALIAQGA--ENTTGPWLCLRCGVNGRPISIPSYRGFRRH 493
            .:|..:|.....|..:::|.:||:| .|...|.  ...:.|.:|..|....|    .||. .|||
Zfish   162 RKGRRSNGEGQEAKTRRKRGESKSM-MLDPDGGSLSPNSKPHICEHCNAAFR----SSYH-LRRH 220

  Fly   494 -LINTHKETIDPALCEHCGWRSVNNRELHFHMYMEHQTKSLLYTFAECALCNQSYRTKGELEAHI 557
             ||:|.:.   |..|..|....:....|..|..:....|..     .|..||..:..|..:|.|
Zfish   221 VLIHTGER---PFRCTQCNMSFIQKYLLQRHEKIHSGEKPF-----SCDQCNMRFIQKYHMERH- 276

  Fly   558 NEVHTDDNKQQCIYCNKVFEQELQLYRHMKSYHKEQALEDGIIDETDEEFLGSQDEEEE-----A 617
            ...|:.:...:|..|.:.|.:..:|.:|.::.  ..|::.| :|..|.| |||..:.|.     :
Zfish   277 KRTHSGEKPYKCDTCQQYFSRTDRLLKHKRTC--GDAIKKG-LDGADHE-LGSAGDTEHGSYGIS 337

  Fly   618 EGDEEQEPEQTGKVRILSD----ISLPATSAITVQQAQQEQLQEEDVEQVQQEVKFVGADGNEVE 678
            :|:......:.||.:...:    ....|:..:.:|.:|                   |.||..|.
Zfish   338 QGNTPTPARKRGKSKTPGEGGERKRKKASGPMGMQHSQ-------------------GVDGYGVH 383

  Fly   679 LTDEQRKEILSQLNQQQAGATAGGVVMVLSEPE----AEH------VKQETDEKSLAGT-----E 728
                   :..|.:|...:..:|.      ::|:    .||      ..::.:.|||..|     .
Zfish   384 -------DFGSAVNHGASTTSAS------AQPDPNIHTEHGQSPKMALKKGNRKSLEKTTHPMVH 435

  Fly   729 EEYDDSQIYSELGAADSV-----ESAKKNIADESKESIDNLEWAENLIAESEEQSNKEPKSDKPR 788
            .:.:|.::.|. |..||:     ..||                    :..|...||        .
Zfish   436 SKPEDMELPSG-GGLDSLGLLPGPGAK--------------------VGPSSSGSN--------Y 471

  Fly   789 DDISEKLKEL-------TGDWTEDENDDDVD-----------------DKPATAEL--ASELANK 827
            ||..:.||:.       :|......:|.||.                 |...|..|  ||.|.:.
Zfish   472 DDAMQFLKKRRYLNVTNSGSAGSGASDYDVSHLQSQPTVNQGVVSGVLDSDGTLSLLDASSLVDI 536

  Fly   828 DPEPTVHEEEDDIDLALQSL-----HKGPEEATE--EKASEESVTSADDAVDAVPNINSQPEKMD 885
            .|:.:...:|     .||||     || |:.:.:  :....|...:|.||.|.:     .||
Zfish   537 KPDKSGIPDE-----VLQSLLDHYAHK-PDVSFDIPDHHHVELQPAAPDATDPL-----GPE--- 587

  Fly   886 VDSEAADEKASKAEVQ------IKKEAELENDQEEF-------IKEDSPIPHSDSVAELREAVTA 937
             |:.::.....||.:.      :.:..|..:....|       :....|.|.:..:...:...|:
Zfish   588 -DNPSSPNSGDKAVIMHEYSRFLLQALERTSHSASFVLGPGSGVTTTGPFPGTSPLLSDKHVYTS 651

  Fly   938 SEGEDDVHLE------------ADNIRKELLDELIAEAEKPDQEKDIVQSEENATTEALDRSVTD 990
            |.      ||            ..::.|....  :.|...|.....:...|::|.|:.|
Zfish   652 SP------LEYSFSHPVSSSPSLSSVPKSHFG--LLEGSSPPPGFHLSSLEQSAHTQQL------ 702

  Fly   991 EDDLVPPTQVSTEQME---IDEPAAEKAAENNEDTRTADEKEAVEDKPNQTQDVTTAEKPTLESA 1052
                 .|:|..|||::   ...|........|          |.:..| |..|:...::|  :..
Zfish   703 -----TPSQELTEQLDKQHTSPPPPPHTPNTN----------AYQIAP-QPPDLGGPKEP--QGP 749

  Fly  1053 KAGDEATSG--------EAASVDKVKS 1071
            |.|..||:|        :.|::|.||:
Zfish   750 KNGATATTGGFSLAASQDLATLDSVKA 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045
		BTB	31..127	CDD:197585
		C2H2 Zn finger	540..568	CDD:275371	7/27 (26%)
		C2H2 Zn finger	569..586	CDD:275371	4/16 (25%)
znf281a	XP_001922388.3	COG5048	<194..>292	CDD:227381	26/111 (23%)
		zf-C2H2	202..224	CDD:278523	9/26 (35%)
		C2H2 Zn finger	204..224	CDD:275368	9/24 (38%)
		zf-H2C2_2	216..241	CDD:290200	9/28 (32%)
		C2H2 Zn finger	232..252	CDD:275368	4/19 (21%)
		zf-H2C2_2	245..269	CDD:290200	6/28 (21%)
		C2H2 Zn finger	260..280	CDD:275368	6/20 (30%)
		zf-H2C2_2	272..297	CDD:290200	6/25 (24%)
		C2H2 Zn finger	288..307	CDD:275368	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24394
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100