DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cp190 and zbtb18

DIOPT Version :9

Sequence 1:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	NP_001076421.1	Gene:	zbtb18 / 100003157	ZFINID:	ZDB-GENE-050419-73	Length:	537	Species:	Danio rerio

Alignment Length:	659	Identity:	116/659 - (17%)
Similarity:	221/659 - (33%)	Gaps:	211/659 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QKLQNFFNKTDYCDLTLQFRDNSQLKVHRLVLSACTDYFNVLEQTCEIVDDALIMPNEFQADVVV 82
            |:.|.|.     ||.|:...| :|.:.||.||::|:.||::..:  :.:|...|:  ...:|:|.
Zfish    17 QRHQGFL-----CDSTVLVGD-AQFRAHRAVLASCSMYFHLFYK--DQLDKRDIV--HLNSDIVT 71

  Fly    83 P-----IVNFMYTGTLEFELKMYGKLLRTAKEMNMTVLLKLLEAHRRTMENVNRQQRPPSPKGIR 142
            .     ::.|||.|.|:|:......:|..|..::|..::|:.:                  |.::
Zfish    72 APAFALLLEFMYEGKLQFKSLPVEDVLAAASYLHMYDIVKVCK------------------KKLK 118

  Fly   143 RRTVGQPSSGLPQQRVLGPSPQSRNVATPIAQRANTQRGSTGNTMSRTSGGSNRSPYGDSSNVKQ 207
            ::...:..|...::.....|.:..:.         ::.||||...:.....|:.....:..:..|
Zfish   119 QKATAEADSTKREEDTSSCSDKVESF---------SEGGSTGRPATADLLQSDDEDMENKRDSPQ 174

  Fly   208 EP----------------TSPFEQLRKGYNNNKRPAQTSLLSPPSKKPSLEEVKEFAEQQRMRKQ 256
            ||                |||.|....|.:..|.||.    ||.|...||      :.:....::
Zfish   175 EPGSMWMRLPSDRTTSPTTSPREAETHGPDAGKSPAG----SPSSSTGSL------SRRSAASRR 229

  Fly   257 IAAEYGDNDPEYDGGMLYDDVHAGDDDDDDMPPQPSTSKQQSPQGTQTQLEHGSTTIILKQDSPS 321
            ::|   |.|...|   |......|....:::...|......:|...|:.|    ..:.:::|:.|
Zfish   230 VSA---DTDCVLD---LSVKSSLGGGPGENIAGNPYFCSSVTPDSLQSAL----VQVKVEKDTGS 284

  Fly   322 QTPTIIVKDSSNAKLNHTKIIAEVLRQYPHIVKGHKNIKLKIMPNTPAAPTEKSAPATVKPPANQ 386
            ....::   |.:.::.|:.:                                      .:||:..
Zfish   285 DDDELV---SGDYEMEHSGV--------------------------------------KEPPSTN 308

  Fly   387 SSATTSPHKKLHVSFKADKSTPLITAQQKAASSQQKSGTSQTTGNQGTGANPPANTAAAQKRRID 451
            .:         |:|..|.:...|    :...|:.:::..:........|.:...:.......|:.
Zfish   309 GT---------HLSLVAQRRLGL----EAHLSALREASLASELERDDKGGDDDTDVLGGDSDRVQ 360

  Fly   452 SKTMHALIAQGAENTTGPWLCLRCGVNGRPISI--------PSYRGFRRHLINTHKET------- 501
            .       |.|.|::..|::....|.....|.:        ||     .|::..|..|
Zfish   361 E-------AAGVESSLLPYVSSMLGAPHTQIFMCPLCNKVFPS-----PHILQIHLSTHFREQEG 413

  Fly   502 --------IDPALCEHCGWRSVNNRELHFHMYMEHQTKSLLYTFAE------------CALCNQS 546
                    ::...|..||                 :|.|.:||...            |..|.:|
Zfish   414 VRAKPAGDVNVPTCSICG-----------------KTFSCMYTLKRHERTHSGEKPYTCTTCGKS 461

  Fly   547 YRTKGELEAHINEVHTDDNKQQCIYCNKVFEQELQLYRHMKSYH---------KEQAL-----ED 597
            ::....|..|. .|||.:....|.:|.:.|.|...||||::.:|         |.:||     .|
Zfish   462 FQYSHNLSRHA-VVHTREKPHACKWCERRFTQSGDLYRHIRKFHCELVNSLSVKSEALNLPTVRD 525

  Fly   598 GIIDETDEE 606
            ..::::.:|
Zfish   526 WALEDSSQE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cp190	NP_524359.2	BTB	20..122	CDD:279045	28/106 (26%)
		BTB	31..127	CDD:197585	25/100 (25%)
		C2H2 Zn finger	540..568	CDD:275371	8/27 (30%)
		C2H2 Zn finger	569..586	CDD:275371	7/16 (44%)
zbtb18	NP_001076421.1	BTB	14..110	CDD:279045	28/102 (27%)
		BTB	25..110	CDD:197585	24/89 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..232		23/128 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..355		1/19 (5%)
		C2H2 Zn finger	387..407	CDD:275368	4/24 (17%)
		COG5048	<388..>496	CDD:227381	24/130 (18%)
		C2H2 Zn finger	427..447	CDD:275368	7/36 (19%)
		zf-H2C2_2	440..462	CDD:290200	2/21 (10%)
		C2H2 Zn finger	455..475	CDD:275368	5/20 (25%)
		C2H2 Zn finger	483..501	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24394
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100