DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Set and SET

DIOPT Version :9

Sequence 1:	NP_650438.2	Gene:	Set / 41844	FlyBaseID:	FBgn0014879	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	XP_016870502.1	Gene:	SET / 6418	HGNCID:	10760	Length:	309	Species:	Homo sapiens

Alignment Length:	274	Identity:	158/274 - (57%)
Similarity:	211/274 - (77%)	Gaps:	17/274 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PKRAKLDGAPADG--NTSAAAG----NNEEESEALEQIDACQNEIDALNEKASEEILKVEQKYNK 63
            |::.|....||.|  .|||:||    ..:|:.||:|.||..|||||.|||:||||||||||||||
Human    11 PQKKKPRPPPALGPEETSASAGLPKKGEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNK 75

  Fly    64 LRKPCYEKRSELVKRIPNFWVTSFINHPQVSGILDEEEEECLHALNKLEVEEFEDIKSGYRINFH 128
            ||:|.::|||||:.:|||||||:|:||||||.:|.||:||.||.|.::||.|||||||||||:|:
Human    76 LRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFY 140

  Fly   129 FDENPYFENKVLTKEFHLNSAAASENGDWPASTSTPIKWKEGKNLLK-LLLTKPYGNKKKRNSEY 192
            ||||||||||||:||||||     |:|| |:|.||.||||.||:|.| ...|:...::|:::.|.
Human   141 FDENPYFENKVLSKEFHLN-----ESGD-PSSKSTEIKWKSGKDLTKRSSQTQNKASRKRQHEEP 199

  Fly   193 KTFFDWFSDNTDPVNDEIAELIKDDLWPNPLQYYLVPDIEVE--PEDEEDNEDNDEEAFD--DED 253
            ::||.||:|::|...||:.|:||||:||||||||||||::.|  ..:|:|::|.:||..:  ||:
Human   200 ESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEGEEDDDDDEEEEGLEDIDEE 264

  Fly   254 GEDGEGEEEEEDED 267
            |::.||||:|:|::
Human   265 GDEDEGEEDEDDDE 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set	NP_650438.2	NAP	31..227	CDD:279323	127/196 (65%)
SET	XP_016870502.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	197	1.000	Domainoid score	I3099
eggNOG	1	0.900	-	-		E1_KOG1508
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55707
Inparanoid	1	1.050	311	1.000	Inparanoid score	I2596
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55441
OrthoDB	1	1.010	-	-		D1191764at2759
OrthoFinder	1	1.000	-	-		FOG0000644
OrthoInspector	1	1.000	-	-		otm42145
orthoMCL	1	0.900	-	-		OOG6_103113
Panther	1	1.100	-	-	O	PTHR11875
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11118
SonicParanoid	1	1.000	-	-		X2181
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.910