DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Set and NAP1L2

DIOPT Version :9

Sequence 1:	NP_650438.2	Gene:	Set / 41844	FlyBaseID:	FBgn0014879	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_068798.1	Gene:	NAP1L2 / 4674	HGNCID:	7638	Length:	460	Species:	Homo sapiens

Alignment Length:	225	Identity:	60/225 - (26%)
Similarity:	98/225 - (43%)	Gaps:	57/225 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EEESEALEQIDACQNEIDALNEKASEEILKVEQKYNKLRKPCYEKRSELVKRIPNFWVTSFINHP 91
            |||.|..|     :::|:|..|:..||                    |..|.||:||:|...|..
Human   213 EEEEEEEE-----EDDIEATGEENKEE--------------------EDPKGIPDFWLTVLKNVD 252

  Fly    92 QVSGILDEEEEECLHALNKLEVEEFEDIKS-GYRINFHFDENPYFENKVLTKEFHLNSAAASENG 155
            .::.::.:.:|..|..|..::|:..:..:. .:.:.|||..|.||:|::|||.:.|.|..|..:
Human   253 TLTPLIKKYDEPILKLLTDIKVKLSDPGEPLSFTLEFHFKPNEYFKNELLTKTYVLKSKLAYYD- 316

  Fly   156 DWP---------ASTSTPIKWKEGKNL-LKLLLTKP----YGNKKKRNSEY--KTFFDWFS---- 200
              |         .||...|.|.||||: ||.:..|.    :|..:....::  .:||::||
Human   317 --PHPYRGTAIEYSTGCEIDWNEGKNVTLKTIKKKQKHRIWGTIRTVTEDFPKDSFFNFFSPHGI 379

  Fly   201 -DNTDPVNDEIAELIKDDLWPNPLQYYLVP 229
             .|....||       |.|..:.|:.|::|
Human   380 TSNGRDGND-------DFLLGHNLRTYIIP 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set	NP_650438.2	NAP	31..227	CDD:279323	55/217 (25%)
NAP1L2	NP_068798.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..88
		NAP	111..410	CDD:279323	60/225 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..238		10/48 (21%)
		Nuclear localization signal. /evidence=ECO:0000255	346..352		1/5 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152047
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840