DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Set and NAP1L1

DIOPT Version :9

Sequence 1:	NP_650438.2	Gene:	Set / 41844	FlyBaseID:	FBgn0014879	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_001317160.1	Gene:	NAP1L1 / 4673	HGNCID:	7637	Length:	391	Species:	Homo sapiens

Alignment Length:	336	Identity:	86/336 - (25%)
Similarity:	142/336 - (42%)	Gaps:	94/336 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DGNTSAAAGNNEEESEALE-QIDACQN------EIDALNEKASEEILKVEQKYNKLRKPCYEKRS 73
            ||......|..|.....:: :::|.:|      :|:|   |..||:..:|:||..|.:|.::||.
Human    57 DGLVETPTGYIESLPRVVKRRVNALKNLQVKCAQIEA---KFYEEVHDLERKYAVLYQPLFDKRF 118

  Fly    74 ELV-------------------------------------------KRIPNFWVTSFINHPQVSG 95
            |::                                           |.||.||:|.|.|...:|.
Human   119 EIINAIYEPTEEECEWKPDEEDEISEELKEKAKIEDEKKDEEKEDPKGIPEFWLTVFKNVDLLSD 183

  Fly    96 ILDEEEEECLHALNKLEVEEFEDI--KSGYRINFHFDENPYFENKVLTKEFHLNSAAASENG--- 155
            ::.|.:|..|..|..::| :|.|.  ...:.:.|||:.|.||.|:||||.:.:.|.....:.
Human   184 MVQEHDEPILKHLKDIKV-KFSDAGQPMSFVLEFHFEPNEYFTNEVLTKTYRMRSEPDDSDPFSF 247

  Fly   156 DWP---ASTSTPIKWKEGKNL-LKLLLTKPYGNKKKRNSEYKT---------FFDWFS------- 200
            |.|   ..|...|.||:|||: ||.:..|   .|.|.....:|         ||::|:
Human   248 DGPEIMGCTGCQIDWKKGKNVTLKTIKKK---QKHKGRGTVRTVTKTVSNDSFFNFFAPPEVPES 309

  Fly   201 ----DNTDPV---NDEIAELIKDDLWPNPLQYYLVPDIEVEPEDEEDNEDNDEEAFDDEDGEDGE 258
                |:.:.:   :.||...:::.:.|..:.|:....||   :|::|.::..|||  ||:||:..
Human   310 GDLDDDAEAILAADFEIGHFLRERIIPRSVLYFTGEAIE---DDDDDYDEEGEEA--DEEGEEEG 369

  Fly   259 GEEEEEDEDDK 269
            .||.:.|.|.|
Human   370 DEENDPDYDPK 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set	NP_650438.2	NAP	31..227	CDD:279323	66/277 (24%)
NAP1L1	NP_001317160.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		NAP	76..343	CDD:307208	66/273 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..163		0/30 (0%)
		Nuclear localization signal. /evidence=ECO:0000255	273..279		1/8 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..391		16/40 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910