DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Set and HSF5

DIOPT Version :9

Sequence 1:	NP_650438.2	Gene:	Set / 41844	FlyBaseID:	FBgn0014879	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	XP_011522585.1	Gene:	HSF5 / 124535	HGNCID:	26862	Length:	603	Species:	Homo sapiens

Alignment Length:	216	Identity:	45/216 - (20%)
Similarity:	75/216 - (34%)	Gaps:	72/216 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DGNTSAAAGNNEEESEALEQIDACQNEIDALNEKASEEILKVEQKYNKL---------------- 64
            |.||     ..|...||:.||      :|.|:.....|::|||...|:.
Human   370 DENT-----KTEVNLEAVFQI------VDELHSSPKLEMVKVEPVENQCPTSPSYRGQHILANSN 423

  Fly    65 -RKPC-YEKRSELVKRIP-NFWVTSFI--NHPQVSGILDEEEE--ECLHALNKLE---VEEFEDI 119
             ..|| ..:.|:|....| ...:.||:  ....|:..|.:..|  ..:|....:|   ::|...|
Human   424 NSNPCSASQASQLEPLTPVGSDIMSFVVGTEQAVACSLPQSPEYIYTIHTAQPVENSTIQESAAI 488

  Fly   120 KSGY-RINFHFDENPYFENKVLTKE---FHLNSAAA----------------------SENGDWP 158
            :..: ::..|.:.||...:.|..:|   |..:...|                      ||.|  |
Human   489 QQAHVKLKEHLNHNPSPSSVVFVQEGPPFSTHQVDANIKCQTSSRENILPSEQMGFLISEMG--P 551

  Fly   159 AS-------TSTPIKWKEGKN 172
            ||       .:||.:::|.::
Human   552 ASKPSEDTGLATPARYREHRS 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Set	NP_650438.2	NAP	31..227	CDD:279323	41/201 (20%)
HSF5	XP_011522585.1	HSF_DNA-bind	20..129	CDD:278854
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900