DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2gamma and EEFSEC

DIOPT Version :9

Sequence 1:	NP_001262587.1	Gene:	eIF2gamma / 41843	FlyBaseID:	FBgn0263740	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	XP_024309460.1	Gene:	EEFSEC / 60678	HGNCID:	24614	Length:	647	Species:	Homo sapiens

Alignment Length:	336	Identity:	95/336 - (28%)
Similarity:	157/336 - (46%)	Gaps:	80/336 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 RQATINIGTIGHVAHGKSTVVKAIS-GVQTVRFKNE---LERNITIKLGYANAKIYKCDNPKCPR 97
            |:..:|:|.:||:..||:.:.:|:| ...|..|..:   .||.||:.||::...:        |.
Human     4 RRVNVNVGVLGHIDSGKTALARALSTTASTAAFDKQPQSRERGITLDLGFSCFSV--------PL 60

  Fly    98 PASFVSDASSKDDSLPCTRLNCSGNFRL-----------VRHVSFVDCPGHDILMATMLNGAAVM 151
            ||...|       |||        .|:.           :..|:.||||||..|:.|::.||.::
Human    61 PARLRS-------SLP--------EFQAAPEAEPEPGEPLLQVTLVDCPGHASLIRTIIGGAQII 110

  Fly   152 DAALLLIAGNESCPQPQTSEHLAAIEIMKLKQILILQNKIDLIKESQAKEQYEEITKFVQGTVA- 215
            |..:|:|...:.. |.|::|.|...:|...|.:::| |||||:.|.:.:...:::||.:|.|:.
Human   111 DLMMLVIDVTKGM-QTQSAECLVIGQIACQKLVVVL-NKIDLLPEGKRQAAIDKMTKKMQKTLEN 173

  Fly   216 ---EGAPIIPISA----------QLKYNIDVLCEYIVNKIPVPPRDFNAPPRLIVIRSFDVNKPG 267
               .||||||::|          :....|..|.|.:.::|.:|.||.:.|..:.|...|.:..
Human   174 TKFRGAPIIPVAAKPGGPEAPETEAPQGIPELIELLTSQISIPTRDPSGPFLMSVDHCFSIKG-- 236

  Fly   268 CEVADLKGGVAGGSILSGVLKVGQEIEVRPGVVTKDSD----GNITC-----RP-IFSRIVSLFA 322
                  :|.|..|:||||.:.:|..:|:  ..:.|:|:    |...|     || .||.:.:|
Human   237 ------QGTVMTGTILSGSISLGDSVEI--PALKKNSETWRVGPWPCFAGGPRPCAFSVVPAL-- 291

  Fly   323 EQNELQYAVPG 333
                :|.:|||
Human   292 ----VQKSVPG 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2gamma	NP_001262587.1	PTZ00327	11..465	CDD:240362	95/336 (28%)
EEFSEC	XP_024309460.1	SelB_euk	8..209	CDD:206676	65/225 (29%)
		SelB_II	224..357	CDD:293897	24/91 (26%)
		eSelB_III	362..501	CDD:294009
		POLO_box	<556..622	CDD:322131
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3276
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810