DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2gamma and eef1a2

DIOPT Version :9

Sequence 1:	NP_001262587.1	Gene:	eIF2gamma / 41843	FlyBaseID:	FBgn0263740	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_001002371.1	Gene:	eef1a2 / 436644	ZFINID:	ZDB-GENE-040718-64	Length:	463	Species:	Danio rerio

Alignment Length:	365	Identity:	84/365 - (23%)
Similarity:	135/365 - (36%)	Gaps:	123/365 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 INIGTIGHVAHGKST----VVKAISGV--QTV----------------------RFKNELERNIT 77
            |||..||||..||||    ::....|:  :|:                      :.|.|.||.||
Zfish     8 INIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGIT 72

  Fly    78 IKLGYANAKIYKCDNPKCPRPASFVSDASSKDDSLPCTRLNCSGNFRLVRHVSFVDCPGHDILMA 142
            |.:     .::|.:..|                                .:::.:|.|||...:.
Zfish    73 IDI-----SLWKFETTK--------------------------------YYITIIDAPGHRDFIK 100

  Fly   143 TMLNGAAVMDAALLLIAGNES------CPQPQTSEHLAAIEIMKLKQILILQNKIDLIKESQAKE 201
            .|:.|.:..|.|:|::|....      ....||.||......:.:||:::..||:|..:.|.:::
Zfish   101 NMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVAVNKMDSTEPSYSEK 165

  Fly   202 QYEEITKFVQGTVAE------GAPIIPISA-----QLK----------YNID---------VLCE 236
            :|:||.|.|...:.:      ..|.:|||.     .|:          :.:|         .|.|
Zfish   166 RYDEIVKEVSAYIKKIGYSPASVPFVPISGWHGDNMLEPSSNMPWFKGWKLDRKEHHAGGVTLLE 230

  Fly   237 YIVNKIPVPPRDFNAPPRLIVIRSFDVNKPGCEVADLKGGVAGGSILSGVLKVGQEIEVRPGVVT 301
            .:...:| |.|..:.|.||.:   .||.|.|.     .|.|..|.:.:|||        ||.:|.
Zfish   231 ALDTIMP-PTRPTDKPLRLPL---QDVYKIGG-----IGTVPVGRVETGVL--------RPSMVV 278

  Fly   302 KDSDGNITCRPIFSRIVSLFAEQNELQYAVPGGLIGVGTK 341
            ..:..|||     :.:.|:......|..|:||..:|...|
Zfish   279 TFAPVNIT-----TEVKSVEMHHESLSEALPGDNVGFNVK 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2gamma	NP_001262587.1	PTZ00327	11..465	CDD:240362	84/365 (23%)
eef1a2	NP_001002371.1	PTZ00141	1..460	CDD:185474	84/365 (23%)
		EF1_alpha	9..238	CDD:206670	55/266 (21%)
		EF1_alpha_II	242..332	CDD:293894	26/93 (28%)
		EF1_alpha_III	336..438	CDD:294004
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592505
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840