DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2gamma and mIF2

DIOPT Version :9

Sequence 1:	NP_001262587.1	Gene:	eIF2gamma / 41843	FlyBaseID:	FBgn0263740	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_651621.2	Gene:	mIF2 / 43382	FlyBaseID:	FBgn0039588	Length:	696	Species:	Drosophila melanogaster

Alignment Length:	484	Identity:	99/484 - (20%)
Similarity:	177/484 - (36%)	Gaps:	143/484 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATAEAQIGVNRNLQKQDLSNLDVSKLTPLSPEVISRQATINIGTIGHVAHGKSTVVKAISGVQT 65
            :||.|.   .|.:.||:    .||:...|.:||::..:..: :..:|||.|||:|::.::.|...
  Fly   131 VATPEE---TNADEQKE----RDVAPRPPAAPELLQPRPPV-VTVMGHVDHGKTTLLDSLRGADV 187

  Fly    66 VRFKNELERNITIKLGYANAKIYKCDNPKCPRPASFVSDASSKDDSLPCTRLNCSGNFRLVRHVS 130
            ...:   ...||..:|                  :|.....:.:                  .|:
  Fly   188 AAGE---AGGITQHIG------------------AFTVTLENGE------------------RVT 213

  Fly   131 FVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKQ--ILILQNKIDL 193
            |:|.|||....|....||...|..:|::|..:.. ..||.|   .|::.|..|  |::..||||.
  Fly   214 FLDTPGHAAFSAMRARGAVATDIIVLVVAAEDGV-MAQTRE---VIQLAKEAQVPIIVALNKIDK 274

  Fly   194 IKESQAKEQYEEITKFVQGTVAEG--APIIPISAQLKYNIDVLCEYIVNKIPVPPRDFNAPPR-- 254
             .|:..::...|:.:........|  ..:|||||....|:::|.|.:..:..:  ....|.|.
  Fly   275 -PEANIEKSKRELAQMGLALEEHGGDVQVIPISALKGTNLELLAEAVSTQATL--MGLKADPTGL 336

  Fly   255 ---LIVIRSFDVNKPGCEVADLKGGV--AGGSILSGVLKVGQEIEVRPGVVTKDSDGNITCRPIF 314
               ::|....|..:.....|.:..|.  .|..:|||:                          ..
  Fly   337 VEGIVVESKTDPRRGKLSTAIVSRGTLRKGSVLLSGL--------------------------AH 375

  Fly   315 SRIVSLFAEQNE-LQYAVPGGLIGVGTKIDPTLCRADRLVGQVLGAVGQLPDIYQELEISYYLLR 378
            :::..||....: |..|.||..:                  ::||        ::||.::..|
  Fly   376 AKVRGLFDHNGQPLSEAPPGTPV------------------EILG--------WRELPLAGDL-- 412

  Fly   379 RLLGVRTDGDKKGARVEKLQKNEILLVNIGSLSTGGRISATKGDLAKIVLTTPVCTEKGEKIALS 443
             :|.|.|  :||...|.|.:::|         |...:|.::..::.|          |.|:....
  Fly   413 -ILEVET--EKKAHAVLKYREHE---------SQQEKIESSSDEIRK----------KEEEHQAK 455

  Fly   444 RRVENH-WRLIGWGQIFGGKTITPVLDSQ 471
            .|.|.. .||.|..::.||:.:..|.:::
  Fly   456 YRAEREARRLAGRFRMRGGQRVKQVDENE 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2gamma	NP_001262587.1	PTZ00327	11..465	CDD:240362	95/466 (20%)
mIF2	NP_651621.2	InfB	158..689	CDD:223606	88/450 (20%)
		IF2_eIF5B	163..327	CDD:206674	46/210 (22%)
		IF2_mtIF2_II	336..431	CDD:293903	26/151 (17%)
		IF-2	482..575	CDD:288813	0/3 (0%)
		mtIF2_IVc	593..680	CDD:293893
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464585
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840