DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2gamma and eEF2

DIOPT Version :9

Sequence 1:	NP_001262587.1	Gene:	eIF2gamma / 41843	FlyBaseID:	FBgn0263740	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_525105.2	Gene:	eEF2 / 35422	FlyBaseID:	FBgn0000559	Length:	844	Species:	Drosophila melanogaster

Alignment Length:	492	Identity:	108/492 - (21%)
Similarity:	167/492 - (33%)	Gaps:	171/492 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 NIGTIGHVAHGKST-----VVKA--ISGVQT--VRF----KNELERNITIKLGYANAKIYKCDNP 93
            |:..|.||.|||||     |.||  |:|.:.  .||    |:|.||.|||| ..|.:..::.:.
  Fly    21 NMSVIAHVDHGKSTLTDSLVSKAGIIAGAKAGETRFTDTRKDEQERCITIK-STAISMYFEVEE- 83

  Fly    94 KCPRPASFVSDASSKDDSLPCTRLNCSGNFRLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLI 158
               :...|::....::.       .|.|..     ::.:|.|||....:.:.....|.|.||:::
  Fly    84 ---KDLVFITHPDQREK-------ECKGFL-----INLIDSPGHVDFSSEVTAALRVTDGALVVV 133

  Fly   159 -AGNESCPQPQTSEHLAAIEIMKLKQILILQNKID---LIKESQAKEQYEEITKFVQGTVAEGAP 219
             ..:..|.|.:|....|..|  ::|.||.: ||:|   |..:..|:|.|:...:.|:.
  Fly   134 DCVSGVCVQTETVLRQAIAE--RIKPILFM-NKMDRALLELQLDAEELYQTFQRIVEN------- 188

  Fly   220 IIPISAQLKYNIDVLCEYIVNKIPVPPRDFNAPPRLIVIRSFDVNKPGCEVADLKGGVAGGSILS 284
                               ||.|.....|...|...:            .|...||.|..||.|.
  Fly   189 -------------------VNVIIATYNDDGGPMGEV------------RVDPSKGSVGFGSGLH 222

  Fly   285 G---VLKVGQEI---EVRPGVV---------------------TKDSDGNIT-CRPIFSRIVSLF 321
            |   .||...|:   :.:..||                     .|::|...: |..|...|..:|
  Fly   223 GWAFTLKQFSEMYSEKFKIDVVKLMNRLWGENFFNAKTKKWQKQKEADNKRSFCMYILDPIYKVF 287

  Fly   322 AEQNELQYAVPGGLIGVGTKIDPTLCRADRLVGQVLGAVGQLPDIYQELEISYYLLRRLLGV--- 383
                                        |.::.            |::.||...|.:  :||
  Fly   288 ----------------------------DAIMN------------YKKEEIGTLLEK--IGVTLK 310

  Fly   384 RTDGDKKGARVEK------LQKNEILLVNIGSLSTGGRISATK-----------GDLAKIVLTTP 431
            ..|.||.|..:.|      |...|.||..| ::.....:.|.|           .|.|.|.:.:
  Fly   311 HEDKDKDGKALLKTVMRTWLPAGEALLQMI-AIHLPSPVVAQKYRMEMLYEGPHDDEAAIAVKS- 373

  Fly   432 VCTEKGE-KIALSRRV--ENHWRLIGWGQIFGGKTIT 465
             |...|. .:.:|:.|  .:..|...:|::|.||..|
  Fly   374 -CDPDGPLMMYISKMVPTSDKGRFYAFGRVFAGKVAT 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2gamma	NP_001262587.1	PTZ00327	11..465	CDD:240362	107/490 (22%)
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	108/492 (22%)
		EF2	20..236	CDD:206672	68/272 (25%)
		EF2_snRNP_like_II	380..474	CDD:293901	8/30 (27%)
		EF2_snRNP_III	489..560	CDD:293918
		aeEF2_snRNP_like_IV	560..732	CDD:238839
		eEF2_snRNP_like_C	728..807	CDD:239763
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464583
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840