DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF2gamma and Eif2s3

DIOPT Version :9

Sequence 1:	NP_001262587.1	Gene:	eIF2gamma / 41843	FlyBaseID:	FBgn0263740	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_001094012.1	Gene:	Eif2s3 / 299027	RGDID:	1561279	Length:	472	Species:	Rattus norvegicus

Alignment Length:	470	Identity:	382/470 - (81%)
Similarity:	415/470 - (88%)	Gaps:	1/470 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATAEAQIGVNR-NLQKQDLSNLDVSKLTPLSPEVISRQATINIGTIGHVAHGKSTVVKAISGVQ 64
            ||..||.:.:.: :|.:|||:.|||:||||||.|||||||||||||||||||||||||||||||.
  Rat     1 MAGGEAGVTLGQPHLSRQDLATLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVH 65

  Fly    65 TVRFKNELERNITIKLGYANAKIYKCDNPKCPRPASFVSDASSKDDSLPCTRLNCSGNFRLVRHV 129
            |||||||||||||||||||||||||.|:|.||||..:.|..||..|..|.......|||:|||||
  Rat    66 TVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHV 130

  Fly   130 SFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKQILILQNKIDLI 194
            |||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||:
  Rat   131 SFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLV 195

  Fly   195 KESQAKEQYEEITKFVQGTVAEGAPIIPISAQLKYNIDVLCEYIVNKIPVPPRDFNAPPRLIVIR 259
            ||||||||||:|..|||||||||||||||||||||||:|:|||||.|||||||||.:.|||||||
  Rat   196 KESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIR 260

  Fly   260 SFDVNKPGCEVADLKGGVAGGSILSGVLKVGQEIEVRPGVVTKDSDGNITCRPIFSRIVSLFAEQ 324
            |||||||||||.||||||||||||.||||||||||||||:|:|||:|.:.|:||||:|||||||.
  Rat   261 SFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEH 325

  Fly   325 NELQYAVPGGLIGVGTKIDPTLCRADRLVGQVLGAVGQLPDIYQELEISYYLLRRLLGVRTDGDK 389
            |:||||.||||||||||||||||||||:|||||||||.||:|:.||||||:||||||||||:|||
  Rat   326 NDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDK 390

  Fly   390 KGARVEKLQKNEILLVNIGSLSTGGRISATKGDLAKIVLTTPVCTEKGEKIALSRRVENHWRLIG 454
            |.|:|:||.|||:|:|||||||||||:||.|.||.|||||.|||||.|||||||||||.||||||
  Rat   391 KAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIG 455

  Fly   455 WGQIFGGKTITPVLD 469
            ||||..|.||.|.:|
  Rat   456 WGQIRRGVTIKPTVD 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2gamma	NP_001262587.1	PTZ00327	11..465	CDD:240362	375/454 (83%)
Eif2s3	NP_001094012.1	PTZ00327	13..466	CDD:240362	375/452 (83%)
		G1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	48..55		6/6 (100%)
		G2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	76..80		3/3 (100%)
		G3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	134..137		2/2 (100%)
		G4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	190..193		2/2 (100%)
		G5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	225..227		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350772
Domainoid	1	1.000	343	1.000	Domainoid score	I1034
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H90888
Inparanoid	1	1.050	755	1.000	Inparanoid score	I533
OMA	1	1.010	-	-		QHG62159
OrthoDB	1	1.010	-	-		D268956at33208
OrthoFinder	1	1.000	-	-		FOG0002790
OrthoInspector	1	1.000	-	-		otm45344
orthoMCL	1	0.900	-	-		OOG6_101121
Panther	1	1.100	-	-	LDO	PTHR42854
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1879
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910