Protein Alignment eIF2gamma and Eif2s3

DIOPT Version :10

• Sequence 1: NP_731993.1
• Gene: eIF2gamma / 41843
• FlyBaseID: FBgn0263740
• Length: 475
• Species: Drosophila melanogaster
• Sequence 2: NP_001094012.1
• Gene: Eif2s3 / 299027
• RGDID: 1561279
• Length: 472
• Species: Rattus norvegicus
• Alignment Length: 470
• Identity: 382/470 - (81%)
• Similarity: 415/470 - (88%)
• Gaps: 1/470 - (0%)

  Fly     1 MATAEAQIGVNR-NLQKQDLSNLDVSKLTPLSPEVISRQATINIGTIGHVAHGKSTVVKAISGVQ 64
            ||..||.:.:.: :|.:|||:.|||:||||||.|||||||||||||||||||||||||||||||.
  Rat     1 MAGGEAGVTLGQPHLSRQDLATLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVH 65

  Fly    65 TVRFKNELERNITIKLGYANAKIYKCDNPKCPRPASFVSDASSKDDSLPCTRLNCSGNFRLVRHV 129
            |||||||||||||||||||||||||.|:|.||||..:.|..||..|..|.......|||:|||||
  Rat    66 TVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHV 130

  Fly   130 SFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKQILILQNKIDLI 194
            |||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||:
  Rat   131 SFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLV 195

  Fly   195 KESQAKEQYEEITKFVQGTVAEGAPIIPISAQLKYNIDVLCEYIVNKIPVPPRDFNAPPRLIVIR 259
            ||||||||||:|..|||||||||||||||||||||||:|:|||||.|||||||||.:.|||||||
  Rat   196 KESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIR 260

  Fly   260 SFDVNKPGCEVADLKGGVAGGSILSGVLKVGQEIEVRPGVVTKDSDGNITCRPIFSRIVSLFAEQ 324
            |||||||||||.||||||||||||.||||||||||||||:|:|||:|.:.|:||||:|||||||.
  Rat   261 SFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEH 325

  Fly   325 NELQYAVPGGLIGVGTKIDPTLCRADRLVGQVLGAVGQLPDIYQELEISYYLLRRLLGVRTDGDK 389
            |:||||.||||||||||||||||||||:|||||||||.||:|:.||||||:||||||||||:|||
  Rat   326 NDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDK 390

  Fly   390 KGARVEKLQKNEILLVNIGSLSTGGRISATKGDLAKIVLTTPVCTEKGEKIALSRRVENHWRLIG 454
            |.|:|:||.|||:|:|||||||||||:||.|.||.|||||.|||||.|||||||||||.||||||
  Rat   391 KAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIG 455

  Fly   455 WGQIFGGKTITPVLD 469
            ||||..|.||.|.:|
  Rat   456 WGQIRRGVTIKPTVD 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2gamma	NP_731993.1	PTZ00327	11..465	CDD:240362	375/454 (83%)
Eif2s3	NP_001094012.1	PTZ00327	13..466	CDD:240362	375/452 (83%)
		G1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	48..55		6/6 (100%)
		G2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	76..80		3/3 (100%)
		G3. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	134..137		2/2 (100%)
		G4. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	190..193		2/2 (100%)
		G5. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	225..227		1/1 (100%)
		Interacts with Cdc123. /evidence=ECO:0000250|UniProtKB:P41091	457..469		7/11 (64%)