DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2gamma and GSPT1

DIOPT Version :9

Sequence 1:	NP_001262587.1	Gene:	eIF2gamma / 41843	FlyBaseID:	FBgn0263740	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_002085.3	Gene:	GSPT1 / 2935	HGNCID:	4621	Length:	637	Species:	Homo sapiens

Alignment Length:	493	Identity:	102/493 - (20%)
Similarity:	189/493 - (38%)	Gaps:	144/493 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LSPEVISRQATINIGTIGHVAHGKSTV---VKAISGVQTVRFKNELERNI--------------- 76
            ::|....::..:|:..||||..||||:   :..::|:...|...:.||..
Human   202 VAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALD 266

  Fly    77 ----------TIKLGYANAKIYKCDNPKCPRPASFVSDASSKDDSLPCTRLNCSGNFRLVRHVSF 131
                      |:::|.|..:..|                                     :|.:.
Human   267 TNQEERDKGKTVEVGRAYFETEK-------------------------------------KHFTI 294

  Fly   132 VDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQP------QTSEHLAAIEIMKLKQILILQNK 190
            :|.|||...:..|:.||:..|.|:|:|:..:...:.      ||.||....:...:|.:::|.||
Human   295 LDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINK 359

  Fly   191 IDLIKESQAKEQYEE-------ITKFVQGTVAEGAPIIPIS----AQLKYNIDVLCEYI------ 238
            :|....:.:.|:|||       ..|.|.....:....:|.|    |.||...|....||
Human   360 MDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIP 424

  Fly   239 -VNKIPVPPRDFNAPPRLIVIRSFDVNKPGCEVADLKGGVAGGSILSGVLKVGQEIEVRP----- 297
             ::.:|...|..:.|.||.::..:         .|: |.|..|.:.||.:..||::.:.|
Human   425 YLDNLPNFNRSVDGPIRLPIVDKY---------KDM-GTVVLGKLESGSICKGQQLVMMPNKHNV 479

  Fly   298 ---GVVTKDSDGNITCRP---IFSRIVSLFAEQNELQYAVPGGLIGVGTKIDP-TLCRADRLV-G 354
               |:::.|.:.: |..|   :..|:..:  |:.|:   :||.::     .|| .||.:.|.. .
Human   480 EVLGILSDDVETD-TVAPGENLKIRLKGI--EEEEI---LPGFIL-----CDPNNLCHSGRTFDA 533

  Fly   355 QVL------------GAVGQLPDIYQELEISYYLLRRLLGVRTDGDKKGARVEKLQKNEILLVNI 407
            |::            .||..:....:|:||:..:   .|..:..|:|...|...::::::.   |
Human   534 QIVIIEHKSIICPGYNAVLHIHTCIEEVEITALI---CLVDKKSGEKSKTRPRFVKQDQVC---I 592

  Fly   408 GSLSTGGRIS-ATKGDLAKIVLTTPVCTEKGEKIALSR 444
            ..|.|.|.|. .|..|..::...|  ..::|:.||:.:
Human   593 ARLRTAGTICLETFKDFPQMGRFT--LRDEGKTIAIGK 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2gamma	NP_001262587.1	PTZ00327	11..465	CDD:240362	102/493 (21%)
GSPT1	NP_002085.3	PAM2	64..81	CDD:284542
GSPT1	NP_002085.3	TEF1	210..634	CDD:227581	101/485 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156848
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840