DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2gamma and Eif2s3y

DIOPT Version :9

Sequence 1:	NP_001262587.1	Gene:	eIF2gamma / 41843	FlyBaseID:	FBgn0263740	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_036141.1	Gene:	Eif2s3y / 26908	MGIID:	1349430	Length:	472	Species:	Mus musculus

Alignment Length:	472	Identity:	379/472 - (80%)
Similarity:	413/472 - (87%)	Gaps:	1/472 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATAEAQIGVNR-NLQKQDLSNLDVSKLTPLSPEVISRQATINIGTIGHVAHGKSTVVKAISGVQ 64
            ||..||.:.:.: :|.:|||:.|||:||||||.|:|||||||||||||||||||||||||||||.
Mouse     1 MAGGEAGVTLGQPHLSRQDLATLDVTKLTPLSREIISRQATINIGTIGHVAHGKSTVVKAISGVH 65

  Fly    65 TVRFKNELERNITIKLGYANAKIYKCDNPKCPRPASFVSDASSKDDSLPCTRLNCSGNFRLVRHV 129
            |||||||||||||||||||||||||.|:..||||..:.|..||..|..|.......|||||||||
Mouse    66 TVRFKNELERNITIKLGYANAKIYKLDDSSCPRPECYRSCGSSTPDEFPSDIPGTKGNFRLVRHV 130

  Fly   130 SFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKQILILQNKIDLI 194
            |||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||:
Mouse   131 SFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLV 195

  Fly   195 KESQAKEQYEEITKFVQGTVAEGAPIIPISAQLKYNIDVLCEYIVNKIPVPPRDFNAPPRLIVIR 259
            ||||||||||:|..|||||||||||||||||||||||:|:|||||.|||||.|||.:.|||||||
Mouse   196 KESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPLRDFTSEPRLIVIR 260

  Fly   260 SFDVNKPGCEVADLKGGVAGGSILSGVLKVGQEIEVRPGVVTKDSDGNITCRPIFSRIVSLFAEQ 324
            |||||||||||.||||||||||||.||||||||||||||:|:||.:|.:.|:||||:|||||||.
Mouse   261 SFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDGEGKLMCKPIFSKIVSLFAEH 325

  Fly   325 NELQYAVPGGLIGVGTKIDPTLCRADRLVGQVLGAVGQLPDIYQELEISYYLLRRLLGVRTDGDK 389
            |:||||.||||||||||||||||||||:|||||||||.||:|:.||||||:||||||||||:|||
Mouse   326 NDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDK 390

  Fly   390 KGARVEKLQKNEILLVNIGSLSTGGRISATKGDLAKIVLTTPVCTEKGEKIALSRRVENHWRLIG 454
            |.|:|:||.|||:|:|||||||||||:||.|.||.|||||.|||||.|||||||||||.||||||
Mouse   391 KAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIG 455

  Fly   455 WGQIFGGKTITPVLDSQ 471
            ||||..|.||.|.:|.:
Mouse   456 WGQIRRGVTIKPTIDDE 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2gamma	NP_001262587.1	PTZ00327	11..465	CDD:240362	372/454 (82%)
Eif2s3y	NP_036141.1	PTZ00327	13..466	CDD:240362	372/452 (82%)
		eIF2_gamma	42..248	CDD:206675	175/205 (85%)
		G1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	48..55		6/6 (100%)
		G2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	76..80		3/3 (100%)
		G3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	134..137		2/2 (100%)
		G4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	190..193		2/2 (100%)
		G5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	225..227		1/1 (100%)
		eIF2_gamma_II	249..362	CDD:293889	94/112 (84%)
		eIF2_gamma_III	365..459	CDD:294011	75/93 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847256
Domainoid	1	1.000	343	1.000	Domainoid score	I1062
eggNOG	1	0.900	-	-		E1_COG3276
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	753	1.000	Inparanoid score	I565
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62159
OrthoDB	1	1.010	-	-		D268956at33208
OrthoFinder	1	1.000	-	-		FOG0002790
OrthoInspector	1	1.000	-	-		otm43274
orthoMCL	1	0.900	-	-		OOG6_101121
Panther	1	1.100	-	-	O	PTHR42854
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2155
SonicParanoid	1	1.000	-	-		X1879
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800