DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2gamma and tif213

DIOPT Version :9

Sequence 1:	NP_001262587.1	Gene:	eIF2gamma / 41843	FlyBaseID:	FBgn0263740	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_595898.1	Gene:	tif213 / 2539738	PomBaseID:	SPBC17G9.09	Length:	446	Species:	Schizosaccharomyces pombe

Alignment Length:	444	Identity:	330/444 - (74%)
Similarity:	382/444 - (86%)	Gaps:	3/444 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NLDVSKLTPLSPEVISRQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELERNITIKLGYANA 85
            |||:|:|:|:.|.:|||||||||||||||||||||||||||||.|||||||||||||||||||||
pombe     4 NLDISELSPIHPAIISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANA 68

  Fly    86 KIYKCDNPKCPRPASFVSDASSKDDSLPCTRLNCSGNFRLVRHVSFVDCPGHDILMATMLNGAAV 150
            |||||.|.:||||..:.|.:|:|:|..||.  .|:....||||||||||||||||||||||||||
pombe    69 KIYKCSNEECPRPGCYRSYSSNKEDHPPCE--ICNSPMNLVRHVSFVDCPGHDILMATMLNGAAV 131

  Fly   151 MDAALLLIAGNESCPQPQTSEHLAAIEIMKLKQILILQNKIDLIKESQAKEQYEEITKFVQGTVA 215
            |||||||||||||||||||||||||||||:||.|:|||||:|||:||.|:|.|:.|.||::||||
pombe   132 MDAALLLIAGNESCPQPQTSEHLAAIEIMQLKHIIILQNKVDLIRESAAEEHYQSILKFIKGTVA 196

  Fly   216 EGAPIIPISAQLKYNIDVLCEYIVNKIPVPPRDFNAPPRLIVIRSFDVNKPGCEVADLKGGVAGG 280
            |.:||:|||||||||||.:.||||.|||:|.|||...|||||||||||||||.||.|||||||||
pombe   197 ENSPIVPISAQLKYNIDAILEYIVKKIPIPVRDFTTAPRLIVIRSFDVNKPGAEVDDLKGGVAGG 261

  Fly   281 SILSGVLKVGQEIEVRPGVVTKDSDGNITCRPIFSRIVSLFAEQNELQYAVPGGLIGVGTKIDPT 345
            |||:|||::..|||:|||:||||.||.|.|:||||||:|||||.|:|:.|||||||||||.:|||
pombe   262 SILTGVLRLNDEIEIRPGIVTKDDDGRIRCQPIFSRIISLFAEHNDLKIAVPGGLIGVGTTVDPT 326

  Fly   346 LCRADRLVGQVLGAVGQLPDIYQELEISYYLLRRLLGVRTDGDKKGARVEKLQKNEILLVNIGSL 410
            |||||||||||||:.|.||::|.||||:|:||||||||:: |||...:|:||.|||:|:|||||.
pombe   327 LCRADRLVGQVLGSKGNLPEVYTELEINYFLLRRLLGVKS-GDKNTTKVQKLAKNEVLMVNIGST 390

  Fly   411 STGGRISATKGDLAKIVLTTPVCTEKGEKIALSRRVENHWRLIGWGQIFGGKTI 464
            |||||:...|.|:|||:||.|.|||.|||:|||||:|.|||||||.::..|||:
pombe   391 STGGRVMMVKADMAKILLTAPACTEIGEKVALSRRIEKHWRLIGWAKVVEGKTL 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2gamma	NP_001262587.1	PTZ00327	11..465	CDD:240362	330/444 (74%)
tif213	NP_595898.1	PTZ00327	3..446	CDD:240362	330/444 (74%)
		eIF2_gamma	24..228	CDD:206675	161/205 (79%)
		eIF2_gamma_II	229..342	CDD:293889	88/112 (79%)
		eIF2_gamma_III	345..438	CDD:294011	62/93 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	322	1.000	Domainoid score	I225
eggNOG	1	0.900	-	-		E1_COG3276
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	671	1.000	Inparanoid score	I115
OMA	1	1.010	-	-		QHG62159
OrthoFinder	1	1.000	-	-		FOG0002790
OrthoInspector	1	1.000	-	-		oto101155
orthoMCL	1	0.900	-	-		OOG6_101121
Panther	1	1.100	-	-	LDO	PTHR42854
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2155
SonicParanoid	1	1.000	-	-		X1879
TreeFam	1	0.960	-	-
	13	12.860