DRSC/TRiP Functional Genomics Resources

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Protein Alignment eIF2gamma and GSPT2

DIOPT Version :10

Sequence 1:NP_731993.1 Gene:eIF2gamma / 41843 FlyBaseID:FBgn0263740 Length:475 Species:Drosophila melanogaster
Sequence 2:NP_060564.2 Gene:GSPT2 / 23708 HGNCID:4622 Length:628 Species:Homo sapiens


Alignment Length:470 Identity:98/470 - (20%)
Similarity:185/470 - (39%) Gaps:102/470 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 PEVISRQATINIGTIGHVAHGKSTV---VKAISGVQTVRFKNELERNITIKLGYANAKIYKCDNP 93
            |....::..:|:..||||..||||:   :..::|:...|...:.||....|    |.:.:.    
Human   195 PSGAPKKEHVNVVFIGHVDAGKSTIGGQIMFLTGMVDKRTLEKYEREAKEK----NRETWY---- 251

  Fly    94 KCPRPASFVSDASSKDDSLPCTRLNCSGNFRLVR-HVSFVDCPGHDILMATMLNGAAVMDAALLL 157
                 .|:..|.:.::.....|.......|...| |.:.:|.|||...:..|:.||:..|.|:|:
Human   252 -----LSWALDTNQEERDKGKTVEVGRAYFETERKHFTILDAPGHKSFVPNMIGGASQADLAVLV 311

  Fly   158 IAGNESCPQP------QTSEHLAAIEIMKLKQILILQNKIDLIKESQAKEQYEE-------ITKF 209
            |:..:...:.      ||.||....:...:|.:::|.||:|....:.:.|:|||       ..|.
Human   312 ISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSIERYEECKEKLVPFLKK 376

  Fly   210 VQGTVAEGAPIIPIS----AQLKYNIDVLCEY--------IVNKIPVPPRDFNAPPRLIVIRSFD 262
            |..:..:....:|.|    |.:|...| .|.:        .::.:|...|..:.|.||.::..: 
Human   377 VGFSPKKDIHFMPCSGLTGANIKEQSD-FCPWYTGLPFIPYLDNLPNFNRSIDGPIRLPIVDKY- 439

  Fly   263 VNKPGCEVADLKGGVAGGSILSGVLKVGQEIEVRPGVVTKDSDGNITCRPIFSRIVSLFAEQNEL 327
                    .|: |.|..|.:.||.:..||::.:.|      :..|:       .::.:.::..|.
Human   440 --------KDM-GTVVLGKLESGSIFKGQQLVMMP------NKHNV-------EVLGILSDDTET 482

  Fly   328 QYAVPGGLIGVGTK-------------IDPT-LCRADR-------------LVGQVLGAVGQLPD 365
            .:..||..:.:..|             .||: ||.:.|             ::.....||..:..
Human   483 DFVAPGENLKIRLKGIEEEEILPGFILCDPSNLCHSGRTFDVQIVIIEHKSIICPGYNAVLHIHT 547

  Fly   366 IYQELEISYYLLRRLLGVRTDGDKKGARVEKLQKNEILLVNIGSLSTGGRIS-ATKGDLAKIVLT 429
            ..:|:||:..:   .|..:..|:|...|...::::::.   |..|.|.|.|. .|..|..::...
Human   548 CIEEVEITALI---SLVDKKSGEKSKTRPRFVKQDQVC---IARLRTAGTICLETFKDFPQMGRF 606

  Fly   430 TPVCTEKGEKIALSR 444
            |  ..::|:.||:.:
Human   607 T--LRDEGKTIAIGK 619

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eIF2gammaNP_731993.1 PTZ00327 11..465 CDD:240362 98/470 (21%)
GSPT2NP_060564.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..49
PAM2 48..64 CDD:429316
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..124
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 146..195 98/470 (21%)
TEF1 198..627 CDD:444074 97/467 (21%)
G1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059 210..217 4/6 (67%)
G2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059 266..270 1/3 (33%)
G3. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059 287..290 1/2 (50%)
G4. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059 349..352 2/2 (100%)
G5. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059 391..393 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

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