DRSC/TRiP Functional Genomics Resources

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Protein Alignment eIF2gamma and GSPT2

DIOPT Version :9

Sequence 1:NP_001262587.1 Gene:eIF2gamma / 41843 FlyBaseID:FBgn0263740 Length:475 Species:Drosophila melanogaster
Sequence 2:NP_060564.2 Gene:GSPT2 / 23708 HGNCID:4622 Length:628 Species:Homo sapiens


Alignment Length:470 Identity:98/470 - (20%)
Similarity:185/470 - (39%) Gaps:102/470 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 PEVISRQATINIGTIGHVAHGKSTV---VKAISGVQTVRFKNELERNITIKLGYANAKIYKCDNP 93
            |....::..:|:..||||..||||:   :..::|:...|...:.||....|    |.:.:.    
Human   195 PSGAPKKEHVNVVFIGHVDAGKSTIGGQIMFLTGMVDKRTLEKYEREAKEK----NRETWY---- 251

  Fly    94 KCPRPASFVSDASSKDDSLPCTRLNCSGNFRLVR-HVSFVDCPGHDILMATMLNGAAVMDAALLL 157
                 .|:..|.:.::.....|.......|...| |.:.:|.|||...:..|:.||:..|.|:|:
Human   252 -----LSWALDTNQEERDKGKTVEVGRAYFETERKHFTILDAPGHKSFVPNMIGGASQADLAVLV 311

  Fly   158 IAGNESCPQP------QTSEHLAAIEIMKLKQILILQNKIDLIKESQAKEQYEE-------ITKF 209
            |:..:...:.      ||.||....:...:|.:::|.||:|....:.:.|:|||       ..|.
Human   312 ISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSIERYEECKEKLVPFLKK 376

  Fly   210 VQGTVAEGAPIIPIS----AQLKYNIDVLCEY--------IVNKIPVPPRDFNAPPRLIVIRSFD 262
            |..:..:....:|.|    |.:|...| .|.:        .::.:|...|..:.|.||.::..: 
Human   377 VGFSPKKDIHFMPCSGLTGANIKEQSD-FCPWYTGLPFIPYLDNLPNFNRSIDGPIRLPIVDKY- 439

  Fly   263 VNKPGCEVADLKGGVAGGSILSGVLKVGQEIEVRPGVVTKDSDGNITCRPIFSRIVSLFAEQNEL 327
                    .|: |.|..|.:.||.:..||::.:.|      :..|:       .::.:.::..|.
Human   440 --------KDM-GTVVLGKLESGSIFKGQQLVMMP------NKHNV-------EVLGILSDDTET 482

  Fly   328 QYAVPGGLIGVGTK-------------IDPT-LCRADR-------------LVGQVLGAVGQLPD 365
            .:..||..:.:..|             .||: ||.:.|             ::.....||..:..
Human   483 DFVAPGENLKIRLKGIEEEEILPGFILCDPSNLCHSGRTFDVQIVIIEHKSIICPGYNAVLHIHT 547

  Fly   366 IYQELEISYYLLRRLLGVRTDGDKKGARVEKLQKNEILLVNIGSLSTGGRIS-ATKGDLAKIVLT 429
            ..:|:||:..:   .|..:..|:|...|...::::::.   |..|.|.|.|. .|..|..::...
Human   548 CIEEVEITALI---SLVDKKSGEKSKTRPRFVKQDQVC---IARLRTAGTICLETFKDFPQMGRF 606

  Fly   430 TPVCTEKGEKIALSR 444
            |  ..::|:.||:.:
Human   607 T--LRDEGKTIAIGK 619

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eIF2gammaNP_001262587.1 PTZ00327 11..465 CDD:240362 98/470 (21%)
GSPT2NP_060564.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..49
PAM2 47..64 CDD:284542
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..124
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 146..195 98/470 (21%)
TEF1 201..625 CDD:227581 97/464 (21%)
EF1_alpha 205..421 CDD:206670 53/229 (23%)
G1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059 210..217 4/6 (67%)
G2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059 266..270 1/3 (33%)
G3. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059 287..290 1/2 (50%)
G4. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059 349..352 2/2 (100%)
G5. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059 391..393 1/1 (100%)
eRF3_II 430..511 CDD:293906 17/103 (17%)
eRF3_C_III 517..623 CDD:294003 21/111 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156847
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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