DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2gamma and HBS1

DIOPT Version :9

Sequence 1:	NP_001262587.1	Gene:	eIF2gamma / 41843	FlyBaseID:	FBgn0263740	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_001286906.1	Gene:	HBS1 / 117365	FlyBaseID:	FBgn0042712	Length:	670	Species:	Drosophila melanogaster

Alignment Length:	294	Identity:	67/294 - (22%)
Similarity:	119/294 - (40%)	Gaps:	70/294 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 EVISRQATINIGTIGHVAHGKSTVVKAI-----SGVQTVRFKNELERNITIKLGYANAKIYKCDN 92
            |...:::.|::..||||..||||::..:     :..|.|..|:|.|..   ||| ..:.:|
  Fly   240 ERADQKSHIHMIVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHEQESK---KLG-KQSFMY---- 296

  Fly    93 PKCPRPASFVSDASSKDDSLPCTRLNCSGNFRL---VRHVSFVDCPGHDILMATMLNGAAVMDAA 154
                   ::|.|.:.::.:...|.  ..|..|:   .:.|:.:|.|||...:..|::||...|.|
  Fly   297 -------AWVLDETGEERARGITM--DVGQSRIETKTKIVTLLDAPGHKDFIPNMISGATQADVA 352

  Fly   155 LLLI--------AGNESCPQPQTSEHLAAIEIMKLKQILILQNKIDLIKESQAKEQYEEI-TKF- 209
            ||::        :|.|.  ..||.||...:..:.:.|:.::.||:|.:..||  :::.|| ||.
  Fly   353 LLVVDATRGEFESGFEL--GGQTREHAILVRSLGVNQLGVVINKLDTVGWSQ--DRFTEIVTKLK 413

  Fly   210 ----VQGTVAEGAPIIPISAQLKYNIDVLCEY--------------IVNKIPVPPRDFNAPPRLI 256
                :.|.........|.|.....|:....:.              ::....:|.|..:.|.|:
  Fly   414 SFLKLAGFKDSDVSFTPCSGLTGENLTKKAQEPALTNWYSGRHLLDVIENFKIPERAIDRPLRM- 477

  Fly   257 VIRSFDVNKPGCEVADLKGGVAGGSILSGVLKVG 290
                        .|:|:..|...|..:||.::.|
  Fly   478 ------------SVSDIYKGTGSGFCISGRVETG 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2gamma	NP_001262587.1	PTZ00327	11..465	CDD:240362	67/294 (23%)
HBS1	NP_001286906.1	HBS1_N	83..145	CDD:286079
		TEF1	241..669	CDD:227581	66/293 (23%)
		EF1_alpha	249..468	CDD:206670	54/239 (23%)
		HBS1-like_II	474..557	CDD:293912	9/39 (23%)
		HBS1_C_III	561..669	CDD:294008
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464580
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840