DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42404 and DGCR2

DIOPT Version :9

Sequence 1:	NP_001247118.1	Gene:	CG42404 / 41842	FlyBaseID:	FBgn0259823	Length:	1133	Species:	Drosophila melanogaster
Sequence 2:	NP_005128.1	Gene:	DGCR2 / 9993	HGNCID:	2845	Length:	550	Species:	Homo sapiens

Alignment Length:	340	Identity:	84/340 - (24%)
Similarity:	128/340 - (37%)	Gaps:	111/340 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SCRDYNGKMYETGMHYMP-GPDSCRLCICDSGLPKACKMVLCEAFSKCKSFQTVGSGNNCCEVIC 91
            :|.|....:.:.|.::.| |.|.|..|.|..|.|:.|...|||....|:.::.  ....||:.:|
Human   270 TCVDIKDNVVDEGFYFTPKGDDPCLSCTCHGGEPEMCVAALCERPQGCQQYRK--DPKECCKFMC 332

  Fly    92 LDDQFSDGSTDF-----GIXLVASGITATLSLSLLFFLVNRLRQRKMRARENRQNAEDQRSIVGS 151
            ||   .||::.|     |:.||.|.|::.|.||||.|:|:|||||:      |:..|   |::|:
Human   333 LD---PDGNSLFDSMASGMRLVVSCISSFLILSLLLFMVHRLRQRR------RERIE---SLIGA 385

  Fly   152 -----------IGYIAGNMGYMEGNLSAIDYSYSG--------------AATHYP-LWKPHFPRG 190
                       .|:..|..|:..| |:.:..|..|              .|..|| :.:|..|
Human   386 NLHHFNLGRRIPGFDYGPDGFGTG-LTPLHLSDDGEGGTFHFHDPPPPYTAYKYPDIGQPDDP-- 447

  Fly   191 EAPPPYEEAV-------------AISQAEALSAQCTVSLPA----SSQRTVATVSQQQQQAVAQA 238
              |||||.::             |....|       |||||    .|:..:....:|.......:
Human   448 --PPPYEASIHPDSVFYDPADDDAFEPVE-------VSLPAPGDGGSEGALLRRLEQPLPTAGAS 503

  Fly   239 QAQAQAQAQAQQQQQIQAQVQAHQHLQQHTLQLHTQPQQHHQPYSQQLVAHPHPQHPHST--ANV 301
            .|..:..|.:                                  |..|:..|.|....||  |..
Human   504 LADLEDSADS----------------------------------SSALLVPPDPAQSGSTPAAEA 534

  Fly   302 LPQSNQYTQSTTNLI 316
            ||...::::|:.|.:
Human   535 LPGGGRHSRSSLNTV 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42404	NP_001247118.1	VWC	32..89	CDD:214564	16/57 (28%)
DGCR2	NP_005128.1	LDLa	30..66	CDD:238060
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..92
		CLECT_DGCR2_like	115..267	CDD:153069
		VWC	271..329	CDD:214564	17/59 (29%)
		Atrophin-1	<428..537	CDD:331285	29/153 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..550		13/84 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008412
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15256
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.100