DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Amt and RHBG

DIOPT Version :9

Sequence 1:	NP_001097800.1	Gene:	Amt / 41841	FlyBaseID:	FBgn0038309	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_065140.3	Gene:	RHBG / 57127	HGNCID:	14572	Length:	458	Species:	Homo sapiens

Alignment Length:	416	Identity:	88/416 - (21%)
Similarity:	140/416 - (33%)	Gaps:	104/416 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NHSN------YVIPGLYDLSVEDTNWVLTSSF---IIFTMQTGFGMLESGCVSIKNEVNIMMKNV 66
            ||||      :..|     |.:|.:.::...|   ::|..:.||..:
Human    49 NHSNADNEFYFRYP-----SFQDVHAMVFVGFGFLMVFLQRYGFSSV------------------ 90

  Fly    67 IDIVLGGFTYWLFGYGMSFGRGPLSNPFIAIGDFLLDPPVGDALMGQIFAAFLFQLSFATTATTI 131
                  |||:.|..:.:.:.        ..:..||.....|...:|   ...:....|...|..|
Human    91 ------GFTFLLAAFALQWS--------TLVQGFLHSFHGGHIHVG---VESMINADFCAGAVLI 138

  Fly   132 VSGAMAERCNFKAYCLFSFLNTAVYCIPAGWVWGEHGFLNKLGAVDIAGSGPVHLIGGASAFA-S 195
            ..||:..:.......|.:.|...::.|      .|...|:.||..|..||..:|..|...... |
Human   139 SFGAVLGKTGPTQLLLMALLEVVLFGI------NEFVLLHLLGVRDAGGSMTIHTFGAYFGLVLS 197

  Fly   196 AAMLGPRL--GRYSEG--YDPLPLGNPVNACMGLFVLWWGWLAFNSGSTYGVSGAKWQYAARAAV 256
            ..:..|:|  .::.:|  |.     :.:.|.:|...||..|.:||:..|  ..||.....|....
Human   198 RVLYRPQLEKSKHRQGSVYH-----SDLFAMIGTIFLWIFWPSFNAALT--ALGAGQHRTALNTY 255

  Fly   257 MTMMGSFGGGFTSSIYSFWRHGGGMDIMDLINGVL-GSLVSITAGCFLYRAWEALVIGAIGSLFC 320
            .::..|..|.|..|  :.....|.:|::.:.|..| |.:|..|:...:...:.||..|.:.....
Human   256 YSLAASTLGTFALS--ALVGEDGRLDMVHIQNAALAGGVVVGTSSEMMLTPFGALAAGFLAGTVS 318

  Fly   321 VLAMPLF-----DRMGVDDPVGASAVHGVCGI----WGVIAVGLFA--------DNPIPLDTTNG 368
            .|....|     .:..|.|..|...:||:.|:    .||:..||..        ::..||.....
Human   319 TLGYKFFTPILESKFKVQDTCGVHNLHGMPGVLGALLGVLVAGLATHEAYGDGLESVFPLIAEGQ 383

  Fly   369 RS----------GLF-------KGGG 377
            ||          |||       .|||
Human   384 RSATSQAMHQLFGLFVTLMFASVGGG 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amt	NP_001097800.1	Ammonium_transp	30..428	CDD:275788	81/391 (21%)
RHBG	NP_065140.3	Ammonium_transp	61..360	CDD:275788	72/353 (20%)
RHBG	NP_065140.3	Interaction with ANK3. /evidence=ECO:0000269\|PubMed:15611082	416..424
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D910733at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X200
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920