DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-4 and SSZ1

DIOPT Version :9

Sequence 1:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_011931.2	Gene:	SSZ1 / 856461	SGDID:	S000001106	Length:	538	Species:	Saccharomyces cerevisiae

Alignment Length:	548	Identity:	161/548 - (29%)
Similarity:	261/548 - (47%)	Gaps:	66/548 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 APAVGIDLGTTYSCVG-VFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTI 67
            :|.:||..|.|.|.:. :.....|::|||..|.|..||.:::...:...|..|..|:..||..||
Yeast     3 SPVIGITFGNTSSSIAYINPKNDVDVIANPDGERAIPSALSYVGEDEYHGGQALQQLIRNPKNTI 67

  Fly    68 FDAKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEV-----------TYKDEKKTFFPEEISS 121
            .:.:..||..||...|..          .|:|.|.:||           ..|:||.|.  :|:.|
Yeast    68 INFRDFIGLPFDKCDVSK----------CANGAPAVEVDGKVGFVISRGEGKEEKLTV--DEVVS 120

  Fly   122 MVLTKMKETAEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLD 186
            ..|.::|..||.|:|..|..||:|||..|::.|:.|.|.:....||.:::.||||:||.:|:...
Yeast   121 RHLNRLKLAAEDYIGSAVKEAVLTVPTNFSEEQKTALKASAAKIGLQIVQFINEPSAALLAHAEQ 185

  Fly   187 KKAVGERNVLIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKK 251
            .....:.||::.|.||...|.:::::.:|||.:.:||.|..|||::.|..||.:|..||::|::.
Yeast   186 FPFEKDVNVVVADFGGIRSDAAVIAVRNGIFTILATAHDLSLGGDNLDTELVEYFASEFQKKYQA 250

  Fly   252 DLTTNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDP 316
            :...|.|:|.:|:......|:|||::|.|:|.||||.:|.|::.||.|.|:|.:...:|......
Yeast   251 NPRKNARSLAKLKANSSITKKTLSNATSATISIDSLADGFDYHASINRMRYELVANKVFAQFSSF 315

  Fly   317 VEKALRDAKLDKSVIHDIVLVGGSTRIPKVQRLLQ-------DLFNGKELNKSINPDEAVAYGAA 374
            |:..:..|:||...|..::|.||.:..||:...|:       ::...:..|.|.||:|..|.|||
Yeast   316 VDSVIAKAELDPLDIDAVLLTGGVSFTPKLTTNLEYTLPESVEILGPQNKNASNNPNELAASGAA 380

  Fly   375 VQAAILHGDKSQEVQDLL--LLDVTP---LSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDN 434
            :||.::....:.|:.:.|  ::..||   ..:|:..|.|....::...|:.|   .|...|....
Yeast   381 LQARLISDYDADELAEALQPVIVNTPHLKKPIGLIGAKGEFHPVLLAETSFP---VQKKLTLKQA 442

  Fly   435 QPGVLIQVYEGE--------RAMTKDNNLLGKFELSGIPPAPRGVPQ------------------ 473
            :...||.||||:        ..:.|:.|.....|.......|..|.:
Yeast   443 KGDFLIGVYEGDHHIEEKTLEPIPKEENAEEDDESEWSDDEPEVVREKLYTLGTKLMELGIKNAN 507

  Fly   474 -IEVTFDIDANGILNVTALERSTNKENK 500
             :|:.|:|:.:|.|.|||.:..|....|
Yeast   508 GVEIIFNINKDGALRVTARDLKTGNAVK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	161/548 (29%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	128/393 (33%)
SSZ1	NP_011931.2	ScSsz1p_like_NBD	4..384	CDD:212674	128/391 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810